Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy.

Abstract:

:Docetaxel is a well-known causative agent of nail alterations. The aim of this study was to reveal the impact of nail alterations associated with low-dose metronomic (LDM) docetaxel chemotherapy on the survival of non-small cell lung cancer (NSCLC) patients. Clinical information, survival data and nail alterations in patients treated with LDM docetaxel chemotherapy (docetaxel 15 mg/m2 per week) were retrospectively reviewed. Forty-nine patients were included in this study. Various nail alterations were observed in 17 of the 49 patients (34.7%). Onycholysis and subungual hyperkeratosis were observed in 22.4% and 10.2% of patients, respectively. The number of docetaxel administration cycles was correlated with the incidence and severity of nail alterations. Univariate and multivariate analysis clearly demonstrated that the occurrence of nail alterations was an independent favorable prognostic factor for overall survival. Nail alterations associated with treatment may act as a surrogate marker for the efficacy of low-dose metronomic docetaxel chemotherapy.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Kibata K,Tamaki T,Inagaki N,Ogata M,Shimizu T,Nomura S

doi

10.3892/ol.2013.1178

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1123-1128

issue

4

eissn

1792-1074

issn

1792-1082

pii

ol-05-04-1123

journal_volume

5

pub_type

杂志文章
  • Descending colo-colonic intussusception secondary to signet ring cell carcinoma: A case report.

    abstract::The incidence of intussusception is low in adults, particularly in the descending colon, due to the anatomical attachment of the descending colon to the retroperitoneum. Signet ring cell histology represents ~1% of colon adenocarcinomas and is associated with young patients and a poor clinical outcome. The present stu...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2805

    authors: Sun KK,Yang D,Gan M,Wu XY

    更新日期:2015-03-01 00:00:00

  • Basic fibroblast growth factor as a potential biomarker for diagnosing malignant tumor metastasis in women.

    abstract::Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6335

    authors: Liu M,Xing LQ

    更新日期:2017-08-01 00:00:00

  • MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1.

    abstract::MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.4001

    authors: Zhao X,Zhu D,Lu C,Yan D,Li L,Chen Z

    更新日期:2016-02-01 00:00:00

  • Molecular-targeted therapy for elderly patients with advanced non-small cell lung cancer.

    abstract::Lung cancer is the most common cause of cancer-related mortality in men and women. Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, >50% of patients are >65 years old. Through an improved understanding of the molecular mechanisms involved in lung oncogenesis, molecular-ta...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3901

    authors: Antonelli G,Libra M,Panebianco V,Russo AE,Vitale FV,Colina P,D'Angelo A,Rossello R,Ferraù F

    更新日期:2016-01-01 00:00:00

  • Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging.

    abstract::The detection and characterisation of tumour-derived circulating epithelial tumor cells (CETCs) or circulating tumor cells (CTCs) have been a main focus of basic oncological research over previous years. Numerous studies in the past decade have shown that CTCs are a promising tool for the estimation of the risk for me...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4878

    authors: Willecke-Hochmuth R,Pachmann K,Drevs J

    更新日期:2016-09-01 00:00:00

  • Overexpression of RHEB is associated with metastasis and poor prognosis in hepatocellular carcinoma.

    abstract::Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7759

    authors: Liu F,Pan Z,Zhang J,Ni J,Wang C,Wang Z,Gu F,Dong W,Zhou W,Liu H

    更新日期:2018-03-01 00:00:00

  • Inflammatory cytokines, appetite-regulating hormones, and energy metabolism in patients with gastrointestinal cancer.

    abstract::This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11662

    authors: Shinsyu A,Bamba S,Kurihara M,Matsumoto H,Sonoda A,Inatomi O,Andoh A,Takebayashi K,Kojima M,Iida H,Tani M,Sasaki M

    更新日期:2020-08-01 00:00:00

  • CXCL12 is associated with FoxP3+ tumor-infiltrating lymphocytes and affects the survival of patients with oral squamous cell carcinoma.

    abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10415

    authors: Zhang B,Wu C,Zhang Z,Yan K,Li C,Li Y,Li L

    更新日期:2019-08-01 00:00:00

  • High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma.

    abstract::Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11490

    authors: Shen A,Ma J,Hu X,Cui X

    更新日期:2020-06-01 00:00:00

  • Effect of BMAP-28 on human thyroid cancer TT cells is mediated by inducing apoptosis.

    abstract::Thyroid cancer is the most common malignant endocrine tumor, with significant morbidity and mortality. Bovine myeloid antimicrobial peptide 28 (BMAP-28) is a cathelicidin that is found in bovine neutrophils. In the present study, the effect and relative mechanism of BMAP-28 on the human thyroid cancer TT cell line in ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3612

    authors: Zhang D,Wan L,Zhang J,Liu C,Sun H

    更新日期:2015-10-01 00:00:00

  • Molecular prognostic factors in rectal cancer treated by preoperative chemoradiotherapy.

    abstract::The present study evaluated the expression of p53, pRb, hMLH1 and MDM2 prior to preoperative chemoradiotherapy (CRT) in patients with rectal cancer, and attempted to determine any correlation with treatment outcome. Forty-five patients with available pretreatment biopsy tissues and who received preoperative CRT were e...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol_00000004

    authors: Nam TK,Lee JS,Kim HR,Ahn SJ,Song JY,Yoon MS

    更新日期:2010-01-01 00:00:00

  • Metaplastic carcinoma of the breast with transformation from adenosquamous carcinoma to osteosarcomatoid and spindle cell morphology.

    abstract::Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1464

    authors: Chuthapisith S,Warnnissorn M,Amornpinyokiat N,Pradniwat K,Angsusinha T

    更新日期:2013-09-01 00:00:00

  • Low-dose bevacizumab induces radiographic regression of vestibular schwannomas in neurofibromatosis type 2: A case report and literature review.

    abstract::The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4347

    authors: Liu P,Yao Q,Li NA,Liu Y,Wang Y,Li M,Li Z,Li J,Li G

    更新日期:2016-05-01 00:00:00

  • Identification of multiple pathways involved in the malignant transformation of endometriosis (Review).

    abstract::The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.690

    authors: Higashiura Y,Kajihara H,Shigetomi H,Kobayashi H

    更新日期:2012-07-01 00:00:00

  • Notch2 inhibits proliferation of chronic myeloid leukemia cells.

    abstract::The Notch signaling pathway has been shown to be involved in the progression of chronic myeloid leukemia (CML). The aim of this study was to investigate the effects of exogenous Notch2 overexpression on cell proliferation and possible mechanisms in the human CML cell line K562. When exogenous intracellular fragment of...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1159

    authors: Yang Z,Yang C,Zhang S,Li Y,Chen J

    更新日期:2013-04-01 00:00:00

  • Downregulation of Frizzled-7 induces the apoptosis of hepatocellular carcinoma cells through inhibition of NF-κB.

    abstract::The aim of the present study was to investigate the functional role of Frizzled-7 (FZD7) in the apoptosis of hepatoma cells. HepG2 and Huh-7 hepatocellular carcinoma (HCC) cell lines with FZD7 expression were selected for use in the present study. The small hairpin RNA (shRNA) eukaryotic expression vector specific to ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8292

    authors: Xue Y,Chen C,Xu W,Xu H,Zheng J,Gu Y

    更新日期:2018-05-01 00:00:00

  • Circulating tumor cell detection: A direct comparison between negative and unbiased enrichment in lung cancer.

    abstract::Circulating tumor cells (CTCs), isolated as a 'liquid biopsy', may provide important diagnostic and prognostic information. Therefore, rapid, reliable and unbiased detection of CTCs are required for routine clinical analyses. It was demonstrated that negative enrichment, an epithelial marker-independent technique for ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6046

    authors: Xu Y,Liu B,Ding F,Zhou X,Tu P,Yu B,He Y,Huang P

    更新日期:2017-06-01 00:00:00

  • Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma.

    abstract::The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were p...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5631

    authors: Huang J,Chen H,Wei Q,Zhang Z,Zhong Z,Xu Y

    更新日期:2017-03-01 00:00:00

  • lncRNA-CD160 decreases the immunity of CD8+ T cells through epigenetic mechanisms in hepatitis B virus infection.

    abstract::The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating the key regulators of cell immune response is needed to improve chronic HBV treatment. Blood samples from patients with chronic HBV infection were used to confirm the correla...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11534

    authors: Wu J,Niu Q,Yuan J,Xu X,Cao L

    更新日期:2020-07-01 00:00:00

  • Budd-Chiari syndrome, a rare complication of multicentric Castleman disease: A case report.

    abstract::A 39-year-old female presented to The First Affiliated Hospital of Jishou University (Jishou, Hunan) with a fever of unknown origin and progressive abdominal distension. Physical examination revealed generalized lymphadenopathy, multiple non-tender cutaneous nodules, hepatomegaly, splenomegaly and abdominal edema. An ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3010

    authors: Song K,Li M

    更新日期:2015-05-01 00:00:00

  • Imbalanced adaptive responses associated with microsatellite instability in cholangiocarcinoma.

    abstract::The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5477

    authors: Loilome W,Kadsanit S,Muisook K,Yongvanit P,Namwat N,Techasen A,Puapairoj A,Khuntikeo N,Phonjit P

    更新日期:2017-02-01 00:00:00

  • A novel approach to glioma therapy using an oncolytic adenovirus with two specific promoters.

    abstract::Gliomas are the most common type of primary brain tumor in adults, where more than half of the cases are malignant, and the prognosis is poor. The early viral 1A (E1A) protein has been widely recognized to be essential for adenoviral replication and production of progeny virions in human cells, a process that is regul...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7684

    authors: Liu F,Xu K,Yang H,Li Y,Liu J,Wang J,Guan Z

    更新日期:2018-03-01 00:00:00

  • γ-Klotho is correlated with resistance to docetaxel in castration-resistant prostate cancer.

    abstract::The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11308

    authors: Onishi K,Miyake M,Hori S,Onishi S,Iida K,Morizawa Y,Tatsumi Y,Nakai Y,Tanaka N,Fujimoto K

    更新日期:2020-03-01 00:00:00

  • Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade.

    abstract::The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who receiv...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11358

    authors: Hamada M,Ebihara Y,Nagata K,Yano M,Kogashiwa Y,Nakahira M,Sugasawa M,Nagatsuka H,Yasuda M

    更新日期:2020-04-01 00:00:00

  • Biological intensity-modulated radiotherapy plus neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer: A case report.

    abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2820

    authors: Huang S,Dang Y,Li F,Wei W,Ma Y,Qiao S,Wang Q

    更新日期:2015-03-01 00:00:00

  • Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer.

    abstract::The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was deter...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6963

    authors: Zhang S,Lei R,Wu J,Shan J,Hu Z,Chen L,Ren X,Yao L,Wang J,Wang X

    更新日期:2017-11-01 00:00:00

  • Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer.

    abstract::Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10644

    authors: Zou Y,Zhang B,Mao Y,Zhang H,Hong W

    更新日期:2019-09-01 00:00:00

  • Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy.

    abstract::The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3969

    authors: Qiu S,Xu Y,Huang L,Zheng W,Huang C,Huang S,Lin J,Lin D,Feng S,Chen R,Pan J

    更新日期:2016-01-01 00:00:00

  • Anillin is a prognostic factor and is correlated with genovariation in pancreatic cancer based on databases analysis.

    abstract::Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pan...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.12368

    authors: Nie Y,Zhao Z,Chen M,Ma F,Fan Y,Kang Y,Kang B,Wang C

    更新日期:2021-02-01 00:00:00

  • Inhibition of urokinase-type plasminogen activator expression by dihydroartemisinin in breast cancer cells.

    abstract::The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1918

    authors: Zhang S,Ma Y,Jiang J,Dai Z,Gao X,Yin X,Xi W,Min W

    更新日期:2014-05-01 00:00:00