Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway.

Abstract:

:The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Dai H,Deng HB,Wang YH,Guo JJ

doi

10.3892/ol.2018.8772

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1579-1583

issue

2

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-8772

journal_volume

16

pub_type

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