Abstract:
:Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin-bound paclitaxel (nab-PTX) is a novel formulation of PTX, which allows reconstitution of the agent with a saline solution instead of solvents and administration without premedication for HSRs. The current study reports the safe administration of nab-PTX to four breast cancer patients considered clinically to have contraindications to PTX or DOC. Two of the patients had previously experienced HSRs to PTX or DOC and the other two patients had contraindications to steroids as a premedication for HSRs, since one patient suffered from diabetes and the other was a carrier of the hepatitis B virus. All 4 patients were safely administered nab-PTX. In conclusion, administration of nab-PTX appears to be effective for patients that have previously experienced HSRs to other taxanes or in those with contraindications to steroids.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kimura K,Tanaka S,Iwamoto M,Fujioka H,Takahashi Y,Sato N,Terasawa R,Tominaga T,Ikari A,Uchiyama Kdoi
10.3892/ol.2013.1471subject
Has Abstractpub_date
2013-10-01 00:00:00pages
881-884issue
4eissn
1792-1074issn
1792-1082pii
ol-06-04-0881journal_volume
6pub_type
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