Polysaccharide peptide isolated from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.

abstract：:Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

journal_title：Oncology letters

authors： Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...

journal_title：Oncology letters

authors： Ichinokawa K,Nakanishi Y,Hida Y,Tsuchikawa T,Kato T,Itoh T,Kaji M,Kaga K,Hirano S

更新日期：2019-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2017.6360.]. ...

journal_title：Oncology letters

authors： Liu X,Guo H,Wei Y,Cai C,Zhang B,Li J

更新日期：2021-02-01 00:00:00

abstract：:The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...

journal_title：Oncology letters

authors： Yuan F,Zhang S,Xie W,Yang S,Lin T,Chen X

更新日期：2020-06-01 00:00:00

abstract：:Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...

journal_title：Oncology letters

authors： Tomasello B,Malfa GA,Strazzanti A,Gangi S,Di Giacomo C,Basile F,Renis M

更新日期：2017-01-01 00:00:00

abstract：:Sorafenib is a multikinase inhibitor and is effective in treating hepatocellular carcinoma (HCC). However, it remains unknown whether sorafenib induces the alteration of protein glycosylation. The present study treated HCC MHCC97L and MHCC97H cells with a 50% inhibitory concentration of sorafenib. Following this treat...

journal_title：Oncology letters

authors： Liu T,Liu R,Zhang S,Guo K,Zhang Q,Li W,Liu Y

更新日期：2017-07-01 00:00:00

abstract：:Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...

journal_title：Oncology letters

authors： Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DH

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression level of microRNA-182 (miRNA-182) in human osteosarcoma (OS) MG-63 cells and OS tissues, and to elucidate the effect of miRNA-182 on the biological activity of tumors. In the present study, the expression of miRNA-182 in human OS MG-63 cells, OS tissues and n...

journal_title：Oncology letters

authors： Bian DL,Wang XM,Huang K,Zhai QX,Yu GB,Wu CH

更新日期：2016-05-01 00:00:00

abstract：:Choroidal melanoma is the most common primary intraocular tumor in adults. Cepharanthine (CEP), a natural alkaloid extracted from the roots of Stephania cepharantha Hayata, has been demonstrated to inhibit the proliferation of various cancer cells. However, its potential anticancer effect in choroidal melanoma has not...

journal_title：Oncology letters

authors： Zhu Q,Guo B,Chen L,Ji Q,Liang H,Wen N,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:Imaging techniques of upper tract urothelial carcinoma (UTUC) are presently limited. Upconversion particles (UCPs) could be used to target tumors for imaging. The present study aimed to assess the value of a nano-UCP as a diagnostic probe for deep tumor tissue, including UTUC. Polymer-coated water-soluble UCPs were sy...

journal_title：Oncology letters

authors： Liao G,Wang L,Yu W

更新日期：2018-11-01 00:00:00

abstract：:Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...

journal_title：Oncology letters

authors： Trybek T,Kowalik A,Góźdź S,Kowalska A

更新日期：2020-08-01 00:00:00

abstract：:The aim of the present study was to investigate whether oridonin is able to increase the effects of lentinan (LNT) in HepG2 human hepatoblastoma cells by MTT, flow cytometry, reverse transcription-quantitative polymerase chain reaction and western blot analysis. The in vitro results demonstrated that 20 µg/ml of orido...

journal_title：Oncology letters

authors： Sun Z,Han Q,Duan L,Yuan Q,Wang H

更新日期：2018-02-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...

journal_title：Oncology letters

authors： Zhang F,Zhu Y,Fan G,Hu S

更新日期：2018-10-01 00:00:00

abstract：:Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...

journal_title：Oncology letters

authors： Zhao SF,Wang SG,Zhao ZY,Li WL

更新日期：2019-11-01 00:00:00

abstract：:Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...

journal_title：Oncology letters

authors： Tas F,Ciftci R,Kilic L,Karabulut S

更新日期：2013-11-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the p...

journal_title：Oncology letters

authors： Dumitrascu MC,Mares C,Petca RC,Sandru F,Popescu RI,Mehedintu C,Petca A

更新日期：2020-12-01 00:00:00

abstract：:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

journal_title：Oncology letters

authors： Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

更新日期：2018-08-01 00:00:00

abstract：:DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...

journal_title：Oncology letters

authors： Yoo KH,Park YK,Chang SG

更新日期：2013-01-01 00:00:00

abstract：:Differences in inflammatory factors IL-6 and miR-1271 expression levels between elderly and young gastric cancer patients were investigated. A retrospective analysis of 146 cases of gastric cancer tissue and normal fresh tissue specimens diagnosed in The First Hospital of Lanzhou University from January 2013 to Januar...

journal_title：Oncology letters

authors： Liu S,Zhou Y,Zhao L,Wang J,Ji R,Wang Y,Wu J,Yan X

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...

journal_title：Oncology letters

authors： You HX,Zhou YH,Tan SY,She TH

更新日期：2014-06-01 00:00:00

abstract：:Brain-specific metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specif...

journal_title：Oncology letters

authors： Wang L,Wang Z,Liu X,Liu F

更新日期：2014-06-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...

journal_title：Oncology letters

authors： Weng W,Zhang P,Ruan J,Zhang Y,Ba D,Tang Y

更新日期：2020-01-01 00:00:00

abstract：:The current report presents the case of a 43-year-old male suffering from a penile cutaneous horn. A surgical excision of the lesion was performed and histopathology demonstrated hyperkeratosis, dyskeratosis and epithelial hyperplasia. The cutaneous horn progressed to squamous cell carcinoma <1.5 months following surg...

journal_title：Oncology letters

authors： Zhou Y,Tang Y,Tang J,Xia B,Dai Y

更新日期：2014-09-01 00:00:00

abstract：:Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...

journal_title：Oncology letters

authors： Ma J,Liang L,Liu H

更新日期：2012-09-01 00:00:00

abstract：:Notch-regulated ankyrin-repeat protein (NRARP) has recently been reported to be involved in a number of malignant cancers; however, its role in non-small lung cancer (NSCLC) remains unclear. The present study aimed to identify whether NRARP could be applied as a novel prognostic marker for NSCLC. A total of 108 NSCLC ...

journal_title：Oncology letters

authors： Liao Y,Chen J,Ma J,Mao Q,Wei R,Zheng J

更新日期：2018-08-01 00:00:00

abstract：:The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affi...

journal_title：Oncology letters

authors： Göstring L,Lindegren S,Gedda L

更新日期：2016-10-01 00:00:00

abstract：:Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and r...

journal_title：Oncology letters

authors： Dong G,Mao Q,Xia W,Xu Y,Wang J,Xu L,Jiang F

更新日期：2016-03-01 00:00:00

abstract：:Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients ...

journal_title：Oncology letters

authors： Zhu G,Xiao D,Sun P

更新日期：2016-04-01 00:00:00

abstract：:Keloids are a type of benign hyperplasia that cause dermatologic dysfunction and esthetic deformity by invading adjacent normal tissues. Little is known about their etiology, therefore, they are a challenge to treat using plastic surgery. In a previous study, it was demonstrated that the expression of the long non-cod...

journal_title：Oncology letters

authors： Li Y,Liang X,Wang P,Long X,Wang X,Meng Z

更新日期：2018-07-01 00:00:00