BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma.

Abstract:

:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct variant of glioblastomas (GBMs) known as epithelioid GBMs (E-GBMs). There are limited studies on whether immunohistochemistry (IHC) can be used to determine the presence of BRAF VE1 mutations in these tumors. The aim of the current study was to examine BRAF V600E mutations in 20 GBMs, including GBMs with epithelioid features, giant cell GBMs and conventional GBMs. V600 mutations were detected using the Cobas 4800 BRAF V600 Mutation Test, and IHC analysis was also performed. Of the 6 cases of GBM with epithelioid features, 1 exhibited a BRAF V600E mutation, while the other cases did not. IHC staining was positive in 3 out of the 8 conventional GBMs. Vemurafenib is a targeted therapy that has mainly been used for the treatment of melanoma patients for several years, and as a possible alternative treatment for cases of GBM harboring BRAF mutations, its existence may make testing for BRAF status important.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

doi

10.3892/ol.2018.8919

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

2402-2408

issue

2

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-8919

journal_volume

16

pub_type

杂志文章
  • Combined use of free vascularised fibula graft and extracorporeally irradiated osteochondral graft for osteosarcoma of the proximal ulna.

    abstract::The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol_00000024

    authors: Ogose A,Hotta T,Shibata M,Kawashima H,Endo N

    更新日期:2010-01-01 00:00:00

  • Abundant expression of HMGB1 in human T-cell lymphotropic virus type I-infected T-cell lines and high plasma levels of HMGB1 in patients with adult T-cell leukemia.

    abstract::High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1851

    authors: Kimura R,Mori N

    更新日期:2014-04-01 00:00:00

  • 18F-fluorodeoxyglucose PET/CT for detection of disease in patients with prostate-specific antigen relapse following radical treatment of a local-stage prostate cancer.

    abstract::The present study aimed to retrospectively review the contribution of 18F-fluorodeoxygluose-positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of biochemical recurrence in patients with a diagnosis of local-stage prostate cancer (PCa) who underwent radical prostatectomy (RP) or receive...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3903

    authors: Öztürk H,Karapolat I

    更新日期:2016-01-01 00:00:00

  • Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells.

    abstract::Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5415

    authors: Meng L,Xu G,Li J,Liu W,Jia W,Ma J,Wei D

    更新日期:2017-01-01 00:00:00

  • A multi-shRNA vector enhances the silencing efficiency of exogenous and endogenous genes in human cells.

    abstract::RNA interference (RNAi) is a powerful technology for suppressing gene function. In most studies, small interfering RNAs (siRNAs) consist of one short hairpin RNA (shRNA) and, therefore, are often unable to achieve loss-of-function of their target genes. In the current study, an RNAi vector containing three shRNAs unde...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5672

    authors: Weng Y,Shi Y,Xia X,Zhou W,Wang H,Wang C

    更新日期:2017-03-01 00:00:00

  • Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer.

    abstract::Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.11069

    authors: Li J,Zheng L,Yan M,Wu J,Liu Y,Tian X,Jiang W,Zhang L,Wang R

    更新日期:2020-01-01 00:00:00

  • Exosome-delivered TRPP2 siRNA inhibits the epithelial-mesenchymal transition of FaDu cells.

    abstract::The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9752

    authors: Wang C,Chen L,Huang Y,Li K,Jinye A,Fan T,Zhao R,Xia X,Shen B,Du J,Liu Y

    更新日期:2019-02-01 00:00:00

  • Molecular pathological predictive diagnostics in a patient with non-small cell lung cancer treated with crizotinib therapy: A case report.

    abstract::Lung cancer is one of the most common malignant cancers in the Czech Republic in men, with the highest mortality rate of all the malignant diseases. The development of biological treatment enables study into novel personalized treatment options. This type of treatment is usually of high quality, and is often demanding...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7167

    authors: Stanek L,Springer D,Konopasek B,Vocka M,Tesarova P,Syrucek M,Petruzelka L,Vicha A,Musil Z

    更新日期:2017-12-01 00:00:00

  • Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling.

    abstract::Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosp...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6793

    authors: Gan Y,Chen Q,Lei Y

    更新日期:2017-10-01 00:00:00

  • Epithelial cell adhesion molecule is overexpressed in hypopharyngeal carcinoma and suppresses the metastasis and proliferation of the disease when downregulated.

    abstract::The epithelial cell adhesion molecule (EpCAM) is overexpressed in the majority of human epithelial carcinomas, and its overexpression is associated with proliferation and neoplastic transformation. However, the precise molecular mechanism involved in EpCAM-related proliferation and metastasis in hypopharyngeal carcino...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2140

    authors: Mu Y,Sa N,Yu L,Lu S,Wang H,Xu W

    更新日期:2014-07-01 00:00:00

  • Triptolide induces protective autophagy and apoptosis in human cervical cancer cells by downregulating Akt/mTOR activation.

    abstract::Triptolide exhibits immunosuppressive, anti-inflammatory, antifertility and antineoplastic functions. However, the anticancer effect of triptolide on cervical cancer and the underlying mechanism remains to be fully understood. The present study assessed the mechanisms underlying the effect of triptolide on the viabili...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9074

    authors: Qin G,Li P,Xue Z

    更新日期:2018-09-01 00:00:00

  • Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2.

    abstract::Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells remains unknown. The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human na...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10658

    authors: Liu B,Liu L,Zang A,Song Z,Yang H,Wang Z,Shang Y,Ma T,Zhang Y

    更新日期:2019-09-01 00:00:00

  • Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor.

    abstract::Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9200

    authors: Liu Y,Liang Y,Li M,Liu D,Tang J,Yang W,Tong D,Jin X

    更新日期:2018-10-01 00:00:00

  • Expression of the epigenetic H3K27me3 modifier genes KDM6A and EZH2 in patients with upper tract urothelial carcinoma.

    abstract::The development of upper tract urothelial carcinoma (UTUC) has been associated with the ingestion of aristolochic acid (AA) in Chinese herbs. The tumors are more malignant and patients have a worse prognosis in China compared with that in Western countries. Recently, whole-genome and exome sequencing of AA-associated ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.12212

    authors: Wang Y,Zhang JX,Wang SF,Zhang Y,He HY

    更新日期:2020-12-01 00:00:00

  • Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner.

    abstract::Liver kinase B1 (LKB1) encodes a serine/threonine kinase and functions as a tumor suppressor. LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in L...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8741

    authors: Ma Q,Xiao P,Sun L,Wang J,Zhong D

    更新日期:2018-07-01 00:00:00

  • Significance and prognosis of epithelial-cadherin expression in invasive breast carcinoma.

    abstract::The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8836

    authors: Yang L,Wang XW,Zhu LP,Wang HL,Wang B,Zhao Q,Wang XY

    更新日期:2018-08-01 00:00:00

  • Overexpression of LIMD2 promotes the progression of non-small cell lung cancer.

    abstract::LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10473

    authors: Zhang F,Qin S,Xiao X,Tan Y,Hao P,Xu Y

    更新日期:2019-08-01 00:00:00

  • MicroRNA-107 may regulate lung cancer cell proliferation and apoptosis by targeting TP53 regulated inhibitor of apoptosis 1.

    abstract::Lung cancer causes over 1.6 million mortalities worldwide annually. MicroRNAs (miRs) are involved in various types of cancer-associated processes. The present study investigated the possible mechanism of miR-107 in the development of lung cancer in order to identify novel targets for clinical treatment. The expression...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11248

    authors: Cai P,Li J,Chen G,Peng B,Yu L,Zhao B,Yu Y

    更新日期:2020-03-01 00:00:00

  • Differential expression of filamin A and its clinical significance in breast cancer.

    abstract::Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1454

    authors: Tian HM,Liu XH,Han W,Zhao LL,Yuan B,Yuan CJ

    更新日期:2013-09-01 00:00:00

  • Interim 18F-FDG PET/CT improves the prognostic value of S-IPI, R-IPI and NCCN-IPI in patients with diffuse large B-cell lymphoma.

    abstract::The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with ne...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7093

    authors: Jiang M,Chen P,Ruan X,Ye X,Pan Y,Zhang J,Huang Q,Zhou W,Wu H,Wang Q

    更新日期:2017-12-01 00:00:00

  • Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma.

    abstract::Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD1...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.981

    authors: Lu Q,Lv G,Kim A,Ha JM,Kim S

    更新日期:2013-01-01 00:00:00

  • Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist.

    abstract::The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1899

    authors: He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

    更新日期:2014-05-01 00:00:00

  • Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis.

    abstract::Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.790

    authors: Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

    更新日期:2012-10-01 00:00:00

  • Sorafenib induced alteration of protein glycosylation in hepatocellular carcinoma cells.

    abstract::Sorafenib is a multikinase inhibitor and is effective in treating hepatocellular carcinoma (HCC). However, it remains unknown whether sorafenib induces the alteration of protein glycosylation. The present study treated HCC MHCC97L and MHCC97H cells with a 50% inhibitory concentration of sorafenib. Following this treat...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6177

    authors: Liu T,Liu R,Zhang S,Guo K,Zhang Q,Li W,Liu Y

    更新日期:2017-07-01 00:00:00

  • Synovial sarcoma arising in the vulva cytogenetically confirmed by SYT break-apart rearrangement fluorescence in situ hybridization: A case report and discussion of diagnostic methods.

    abstract::Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis that rarely occurs in the female genital tract. We report a case of SS occurring in the right vulva of a young Japanese female. The tumor was composed of poorly differentiated rounded cell areas, surrounded by fibroblastic spindle-shaped cell areas...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.857

    authors: Kawauchi S,Ihara K,Nishikawa K,Sugino N,Takahashi M,Sasaki1 K

    更新日期:2012-11-01 00:00:00

  • The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women.

    abstract::Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.581

    authors: Al-Qasem A,Toulimat M,Tulbah A,Elkum N,Al-Tweigeri T,Aboussekhra A

    更新日期:2012-04-01 00:00:00

  • Superselective internal iliac arterial embolization for severe hemorrhage following radical prostatectomy.

    abstract::Severe hemorrhage following a prostatectomy is a rare and serious complication. A 63-year-old male with severe hemorrhage following radical prostatectomy which led to hypovolemic shock presented at our department and was treated with superselective internal iliac arterial embolization. At 6 months follow-up, the patie...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.749

    authors: Cheng S,Xu L,Li G,Chen Y,Hu H,Zhang Z,Ding G

    更新日期:2012-09-01 00:00:00

  • Potential relationship between Sirt3 and autophagy in ovarian cancer.

    abstract::Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylase...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2020.12023

    authors: Shi Y,He R,Yang Y,He Y,Zhan L,Wei B

    更新日期:2020-11-01 00:00:00

  • Effect of prophylactic TACE on 5-year survival of patients with hepatocellular carcinoma after hepatectomy.

    abstract::The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10517

    authors: He S,Fan X,Ma H,Xiaerfuhazi H,Rehato A,Feng J,Shi X,He F

    更新日期:2019-08-01 00:00:00

  • Giant malignant mesothelioma in the upper mediastinum: A case report.

    abstract::Malignant mesothelioma in the mediastinum is rare and the majority of known cases have been reported as 'localized mesothelioma'. The present study reports a case of an upper mediastinal tumor, which was diagnosed through thoracoscopic surgery and surgical biopsies of the mass. A computed tomography scan revealed a gi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1333

    authors: Zhang S,Song P,Zhang B

    更新日期:2013-07-01 00:00:00