Abundant expression of HMGB1 in human T-cell lymphotropic virus type I-infected T-cell lines and high plasma levels of HMGB1 in patients with adult T-cell leukemia.

abstract：:Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...

journal_title：Oncology letters

authors： He D,Yan L,Ma X,Cheng Y,Wu S,Zuo J,Park EJ,Liu J,Wu M,Choi JI,Tong H

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...

journal_title：Oncology letters

authors： Su L,Liu M

更新日期：2018-07-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is an established cancer stem cell marker and is a target gene of the Wnt/β-catenin signaling pathway, a critical pathway in the process of tumor initiation and growth. In the present study, the mRNA expression levels of LGR5, adenomatous polyposis col...

journal_title：Oncology letters

authors： Lin YU,Wu T,Yao Q,Zi S,Cui L,Yang M,Li J

更新日期：2015-06-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy affecting pediatric and adult populations. Although the outcomes of ALL in children have improved markedly in previous years, limited treatment strategies are available at present for adult patients with ALL. Wee1 is a crucial cell cycle checkp...

journal_title：Oncology letters

authors： Duan Y,Dong X,Nie J,Li P,Lu F,Ma D,Ji C

更新日期：2018-10-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated ...

journal_title：Oncology letters

authors： Zhou N,Lu F,Liu C,Xu K,Huang J,Yu D,Bi L

更新日期：2016-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...

journal_title：Oncology letters

authors： Yamaura T,Muto S,Mine H,Takagi H,Watanabe M,Ozaki Y,Inoue T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2020-06-01 00:00:00

abstract：:The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...

journal_title：Oncology letters

authors： Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...

journal_title：Oncology letters

authors： Xu L,Zeng Z,Chen B,Wu X,Yu J,Xue L,Tian L,Wang Y,Chen M,Sung JJ,Hu P

更新日期：2011-03-01 00:00:00

abstract：:Nucleobindin 2 (NUCB2) is mainly expressed in the hypothalamic nuclei and has a proven role in energy homeostasis. It has also been recently reported to have a key role in tumor progression. However, the clinical significance of NUCB2 in colorectal cancer (CRC) remains unknown. In the present study, the level of NUCB2...

journal_title：Oncology letters

authors： Xie J,Chen L,Chen W

更新日期：2018-06-01 00:00:00

abstract：:Carbon dioxide (CO2) laser ablation in combination with photodynamic therapy (PDT) has previously been successfully used to treat superficial basal cell carcinoma (BCC). However, the efficacy of this treatment modality is limited in the treatment of deeper lesions and the more aggressive subtypes of BCC. In order to i...

journal_title：Oncology letters

authors： Kim SA,Lee KS,Cho JW

更新日期：2013-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant type of glioma, with a poor prognosis for patients. The survival time of patients varies greatly due to the complexity of the human genome, which harbors diverse oncogenic drivers. In order to identify the specific driving factors, 325 glioma samples from ...

journal_title：Oncology letters

authors： Zeng F,Wang K,Huang R,Liu Y,Zhang Y,Hu H

更新日期：2019-07-01 00:00:00

abstract：:The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultras...

journal_title：Oncology letters

authors： Liang B,Xie YG,Xu XP,Hu CH

更新日期：2018-05-01 00:00:00

abstract：:Glioblastomas are the most common primary and malignant brain tumors. The standard therapy includes surgery and radiotherapy plus chemotherapy, with additional bevacizumab to block the angiogenesis in tumors. However, the ever-growing tolerance of glioblastomas to chemotherapeutic drugs impairs the clinical outputs of...

journal_title：Oncology letters

authors： Huang H,Song J,Liu Z,Pan L,Xu G

更新日期：2018-02-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...

journal_title：Oncology letters

authors： Zou Z,Gan S,Liu S,Li R,Huang J

更新日期：2019-07-01 00:00:00

abstract：:The present study aimed to investigate the effect of microRNA-150 (miRNA/miR-150) in osteosarcoma (OS) cell invasion and metastasis by the regulation of Ezrin. To compare the differences in the expression of miR-150 and Ezrin, cell models of OS metastasis were established by exogenous transfection of miR-150 on the ba...

journal_title：Oncology letters

authors： Zhan C,Li C,Zhang H,Tang H,Ji F,Qiao SC,Xu WD,Wang ZW

更新日期：2016-11-01 00:00:00

abstract：:Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...

journal_title：Oncology letters

authors： Lee YH,Yang HW,Yang LC,Lu MY,Tsai LL,Yang SF,Huang YF,Chou MY,Yu CC,Hu FW

更新日期：2017-07-01 00:00:00

abstract：:Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...

journal_title：Oncology letters

authors： Togashi Y,Masago K,Ito Y,Sakamori Y,Okuda C,Fukuhara A,Nagai H,Kim YH,Mishima M

更新日期：2013-02-01 00:00:00

abstract：:ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...

journal_title：Oncology letters

authors： Liu X,Li G,Ai L,Ye Q,Yu T,Yang B

更新日期：2019-08-01 00:00:00

abstract：:Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...

journal_title：Oncology letters

authors： Kim J,Jung J,Lee SJ,Lee JS,Park MJ

更新日期：2012-03-01 00:00:00

abstract：:In the present study, the effect of immunophenotyping on the prognoses of patients with multiple myeloma (MM) treated with bortezomib plus dexamethasone was investigated. The study involved 46 patients with MM, and analyzed the prognostic significance of the expression of cluster of differentiation (CD)45, CD56 and ma...

journal_title：Oncology letters

authors： Iriyama N,Miura K,Hatta Y,Kobayashi S,Uchino Y,Kurita D,Sakagami H,Takahashi H,Sakagami M,Kobayashi Y,Nakagawa M,Ohtake S,Iizuka Y,Takei M

更新日期：2017-05-01 00:00:00

abstract：:Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...

journal_title：Oncology letters

authors： Tas F,Ciftci R,Kilic L,Karabulut S

更新日期：2013-11-01 00:00:00

abstract：:In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...

journal_title：Oncology letters

authors： Wang H,Yang R,Zhong L,Zhu XY,Ma PP,Yang XQ,Jiang KL,Liu BZ

更新日期：2017-04-01 00:00:00

abstract：:Controversy exists regarding a possible association between prostatitis and prostate cancer. To further evaluate the incidence of prostate cancer following prostatitis, a study of prostate cancer incidence in a cohort of Finnish men was performed. The original survey evaluating self-reported prostatitis was conducted ...

journal_title：Oncology letters

authors： Vaarala MH,Mehik A,Ohtonen P,Hellström PA

更新日期：2016-08-01 00:00:00

abstract：:Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non...

journal_title：Oncology letters

authors： Liu S,Yang Y,Chen L,Liu D,Dong H

更新日期：2018-06-01 00:00:00

abstract：:The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected fro...

journal_title：Oncology letters

authors： Chang H,Ma M,Ma R,Zhang C,Zeng W,Xing LQ

更新日期：2016-12-01 00:00:00

abstract：:The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...

journal_title：Oncology letters

authors： Liu P,Yao Q,Li NA,Liu Y,Wang Y,Li M,Li Z,Li J,Li G

更新日期：2016-05-01 00:00:00