TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC.

abstract：:Pancreatic cancer is one of the most frequently occurring malignancies worldwide and it is the fourth most common cause of cancer-associated mortality in Western countries. Thalidomide (THD) plays an important role in tumor therapy, as it is able to promote early stage apoptosis and inhibit the process of angiogenesis...

journal_title：Oncology letters

authors： Qiao Z,Yuan J,Shen J,Wang C,He Z,Hu Y,Zhang M,Xu C

更新日期：2015-05-01 00:00:00

abstract：:Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also...

journal_title：Oncology letters

authors： Xu F,Liu G,Wang L,Wang X,Jin X,Bo W

更新日期：2020-08-01 00:00:00

abstract：:Previous studies have shown that the activation of the β2 adrenergic receptor (ADRB2) can stimulate several signaling pathways that promote tumor growth and metastasis. β-adrenergic antagonism may have a beneficial role in cancer treatment; however, little is known about the effect of ADRB2 inhibition on the growth of...

journal_title：Oncology letters

authors： Dang D,Zhang J,Yang J

更新日期：2018-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate, particularly in Southern China. Apogossypolone (ApoG2) is a novel derivative of gossypol with antitumor activity and less toxicity. The human NPC CNE-2 cell line was studied in the in vitro model; whilst 4 week-old male nude mice (BALB/c-nu) were ...

journal_title：Oncology letters

authors： Zheng R,Chen K,Zhang Y,Huang J,Shi F,Wu G,Wang S

更新日期：2017-07-01 00:00:00

abstract：:In clinical practice ionizing radiation (IR) is primarily applied to cancer treatment in the form of fractionated dose (FD) irradiation. Despite this fact, a substantially higher amount of current knowledge in the field of radiobiology comes from in vitro studies based on the cellular response to single dose (SD) irra...

journal_title：Oncology letters

authors： Stankevicius V,Kuodyte K,Schveigert D,Bulotiene D,Paulauskas T,Daniunaite K,Suziedelis K

更新日期：2017-06-01 00:00:00

abstract：:Breast cancer is one of the most prevalent types of cancer in women and contributes to 32% of all female cancer cases. Cathepsins, a family of proteins, are known to have a critical role in human cancers. However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are ...

journal_title：Oncology letters

authors： Sun T,Jiang D,Zhang L,Su Q,Mao W,Jiang C

更新日期：2016-01-01 00:00:00

abstract：:Emerging evidence has revealed that mitochondrial DNA (mtDNA) is encapsulated in plasma extracellular vesicles (EVs). However, the characteristics of mtDNA in EVs from patients with cancer remain largely unexplored, which greatly limits its clinical application. Whole genome and capture-based sequencing found that EV ...

journal_title：Oncology letters

authors： Li Y,Guo X,Guo S,Wang Y,Chen L,Liu Y,Jia M,An J,Tao K,Xing J

更新日期：2020-09-01 00:00:00

abstract：:Pristimerin is an active compound isolated from the traditional Chinese herbs Celastraceae and Hippocrateaceae. It has been reported to exert antitumor effects under experimental and clinical conditions; however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been iden...

journal_title：Oncology letters

authors： Wu H,Li L,Ai Z,Yin J,Chen L

更新日期：2019-03-01 00:00:00

abstract：:The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...

journal_title：Oncology letters

authors： Li SY,Ye JY,Meng FY,Li CF,Yang MO

更新日期：2015-07-01 00:00:00

abstract：:In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...

journal_title：Oncology letters

authors： Sekido Y,Mukai M,Yamazaki M,Tajima T,Yamamoto S,Hasegawa S,Kishima K,Tajiri T,Nakamura N

更新日期：2014-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...

journal_title：Oncology letters

authors： Zhang F,Zhu Y,Fan G,Hu S

更新日期：2018-10-01 00:00:00

abstract：:This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...

journal_title：Oncology letters

authors： Zhang Y,Gu X,Meng Y,Guo H,Du J,Xing W

更新日期：2018-03-01 00:00:00

abstract：:Effect of crizotinib on apoptosis of lung cancer cells was investigated. Human non-small cell lung adenocarcinoma H2228 cells were cultured in the presence of 0, 20, 40, 80, 160 and 320 nmol/l of crizotinib for 3 days, respectively. The inhibition rate of cell proliferation was measured by MTT assay, and half maximal ...

journal_title：Oncology letters

authors： Lu H,Wu S,Chen H,Huang Y,Qiu G,Liu L,Li Y

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to construct the eukaryotic expression vector pEGFP-N1-hPer2 and assess its expression in the human osteosarcoma cell line MG63. Total mRNA was extracted from human osteosarcoma MG63 cells, the human period 2 (hPer2) gene was obtained by reverse transcription-polymerase chain reaction (RT-PCR...

journal_title：Oncology letters

authors： Cheng A,Zhang Y,Mei H,Fang S,Ji P,Yang J,Yu L,Guo W

更新日期：2016-04-01 00:00:00

abstract：:The surgical treatment of patients with advanced lung cancer remains controversial. The current study aimed to identify the factors affecting the prognosis of patients with stage IV non-small cell lung cancer (NSCLC) and to clarify the surgery guidelines. A total of 27,725 patients diagnosed with stage IV NSCLC were s...

journal_title：Oncology letters

authors： Liao Y,Fan X,Wang X

更新日期：2019-07-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...

journal_title：Oncology letters

authors： Zhang J,Ou Y,Ma Y,Zheng L,Zhang X,Xia R,Kong F,Shen Y,Wang S,Lin L

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to investigate the functional role of Frizzled-7 (FZD7) in the apoptosis of hepatoma cells. HepG2 and Huh-7 hepatocellular carcinoma (HCC) cell lines with FZD7 expression were selected for use in the present study. The small hairpin RNA (shRNA) eukaryotic expression vector specific to ...

journal_title：Oncology letters

authors： Xue Y,Chen C,Xu W,Xu H,Zheng J,Gu Y

更新日期：2018-05-01 00:00:00

abstract：:Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...

journal_title：Oncology letters

authors： Xie J,Lin W,Huang L,Xu N,Xu A,Chen B,Watanabe M,Liu C,Huang P

更新日期：2018-09-01 00:00:00

abstract：:Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...

journal_title：Oncology letters

authors： Wu Y,Bai X,Li X,Zhu C,Wu ZP

更新日期：2018-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...

journal_title：Oncology letters

authors： You HX,Zhou YH,Tan SY,She TH

更新日期：2014-06-01 00:00:00

abstract：:The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...

journal_title：Oncology letters

authors： Hu Y,Tang Z,Jiang B,Chen J,Fu Z

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to investigate the long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA regulatory network in gastric cancer (GC) using bioinformatics analysis. Two mRNA gene expression profiles, GSE79973 and GSE54129, and two miRNA expression profiles, GSE93415 and GSE78091, were downloaded from the Ge...

journal_title：Oncology letters

authors： Ma XY,Ma Y,Zhou H,Zhang HJ,Sun MJ

更新日期：2019-12-01 00:00:00

abstract：:The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...

journal_title：Oncology letters

authors： Liu P,Yao Q,Li NA,Liu Y,Wang Y,Li M,Li Z,Li J,Li G

更新日期：2016-05-01 00:00:00

abstract：:Giant osteomas of the ethmoid and frontal sinuses ary very rare, with only a few dozen cases reported in the literature. Given their rarity, the clinical characteristics and treatment of this disease remain controversial. In this study, the clinical presentation and surgical methods used to treat three patients with g...

journal_title：Oncology letters

authors： Cheng KJ,Wang SQ,Lin L

更新日期：2013-05-01 00:00:00

abstract：:Atorvastatin (ATST), a drug commonly used to reduce the levels of cholesterol and low-density lipoproteins, is a prospective agent for the prevention of colorectal cancer in patients with hyperlipidemia. ATST in combination with functional components is a promising strategy for cancer chemoprevention. In the present s...

journal_title：Oncology letters

authors： Zhou M,Zheng J,Bi J,Wu X,Lyu J,Gao K

更新日期：2018-02-01 00:00:00

abstract：:Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...

journal_title：Oncology letters

authors： Öztürk H

更新日期：2015-03-01 00:00:00

abstract：:The present study aimed to investigate the effects of Na+/H+ exchanger regulatory factor 1 (NHERF1) gene knockdown, using short-hairpin RNA (shRNA), on the malignant behaviors of prostate cancer cells. A pSuper.puro NHERF1 shRNA vector was transfected into PC-3M prostate cancer cells using Lipofectamine 2000. Stable c...

journal_title：Oncology letters

authors： Ma Q,Jiao Y,Hao Y,Yan S,Lyu N,Gao H,Li D,Liu Q,Zheng J,Song N

更新日期：2016-02-01 00:00:00

abstract：:Mosquito coils, which are commonly used as residential insecticides in Asia, contain different concentrations of octachlorodipropyl ether (S-2) as a synergist or an active ingredient. As bis(chloromethyl) ether (BCME) is an extremely potent lung carcinogen that can be produced by the thermolytic degradation of S-2, co...

journal_title：Oncology letters

authors： Zhang J,Qi HW,Sun YP,Xie HK,Zhou CC

更新日期：2015-04-01 00:00:00