Abstract:
:Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transcriptional activity in the progression of HCC cells were investigated. A case-control study was analyzed in 1,056 HCC patients and 1,080 healthy individuals using the PCR assay method. Results indicated AKT1 expression levels were up-regulated in HCC tissue compared to adjacent normal tissues. Furthermore, a higher frequency of AKT rs2494752 AG and AA genotypes were observed in HCC cases (P=0.0046). Gene polymorphism identified C and T alleles were frequency in HCC patients compared to healthy individuals. Individuals harboring AKT rs2494752 AG/AA genotype had a vital increased susceptibility to HCC in the dominant model (P=0.0028). In addition, AKT1 rs2494752 GG genotype showed an increasing of AKT1 promoter activity determined by the luciferase assay. Furthermore, it was demonstrated that AKT1 rs2494752 GG and C polymorphism was more aggressive than other AKT1 rs2494752 cancer cells. Moreover, AKT1 rs2494752 GG markedly increased rates of response to NCT chemotherapy. Additionally, results revealed that AKT1 rs2494752 GG and C increased the risk factors of HCC. In conclusion, these results indicate that AKT1 rs2494752 polymorphisms may be regarded as a candidate gene in assessing the susceptibility, metastasis and responses to chemotherapy in the progression of hepatocellular carcinoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang Z,Fu H,Li Wdoi
10.3892/ol.2018.9060subject
Has Abstractpub_date
2018-09-01 00:00:00pages
3699-3705issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-9060journal_volume
16pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16(INK4a), p53 and nuclear factor κB (NF-κB). In the present stud...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000106
更新日期:2010-07-01 00:00:00
abstract::The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8983
更新日期:2018-09-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6699
更新日期:2017-10-01 00:00:00
abstract::Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5906
更新日期:2017-05-01 00:00:00
abstract::A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1447
更新日期:2013-09-01 00:00:00
abstract::Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2440
更新日期:2014-11-01 00:00:00
abstract::The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18F-FDG PE...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8660
更新日期:2018-07-01 00:00:00
abstract::The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9752
更新日期:2019-02-01 00:00:00
abstract::The management of recurrent diffuse low-grade gliomas (LGGs) is controversial. In the present study, the multidisciplinary management of 35 patients with recurrent LGGs was retrospectively analyzed. Tumor progression or recurrence was defined by clinical, radiological and/or metabolic pejorative evolution. All patient...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6543
更新日期:2017-09-01 00:00:00
abstract::Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell lin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12321
更新日期:2021-01-01 00:00:00
abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11917
更新日期:2020-10-01 00:00:00
abstract::The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1407
更新日期:2013-08-01 00:00:00
abstract::Cerebroma, a nervous system tumor located in the cranial cavity, seriously affects health and may even become life-threatening. The aim of the study was to investigate and discuss the expression levels of cluster of differentiation 44 (CD44) and Golgi protein 73 (GP73) in different types of cerebroma tissues and to st...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7904
更新日期:2018-04-01 00:00:00
abstract::Previous studies have demonstrated that nicotinamide N-methyltransferase (NNMT) is aberrantly expressed in a number of tumors. In the present study, it was demonstrated that the gene and protein levels of NNMT were significantly increased in gastric cancer cells. Furthermore, upregulation of NNMT significantly increas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7885
更新日期:2018-04-01 00:00:00
abstract::Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11948
更新日期:2020-10-01 00:00:00
abstract::Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6178
更新日期:2017-07-01 00:00:00
abstract::Chylothorax is the accumulation of lymph fluid in the pleura. Gastric carcinoma with chylothorax and lymphedema as the initial manifestations has rarely been reported, with only 14 cases reported to date. The mechanisms of gastric carcinoma generating chylothorax have not yet been determined. The current study reports...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4285
更新日期:2016-04-01 00:00:00
abstract::The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2826
更新日期:2015-03-01 00:00:00
abstract::The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. Pancreatic carcinoma is one of the most malignant human cancer type...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7178
更新日期:2017-12-01 00:00:00
abstract::The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4064
更新日期:2016-02-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2521
更新日期:2014-11-01 00:00:00
abstract::Pleural effusion (PE) is a common manifestation associated with certain chest diseases. However, there is no effective diagnostic marker with high sensitivity and specificity. The aim of the present study was to evaluate the diagnostic performance of several biomarkers in the use of detecting malignant pleural disorde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8871
更新日期:2018-08-01 00:00:00
abstract::Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8453
更新日期:2018-06-01 00:00:00
abstract::The aim of the present study was to evaluate the curative effect of fludeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT)-guided intensity-modulated radiotherapy (IMRT) for 42 patients with International Federation of Gynecology and Obstetrics (FIGO) stage III/IV ovarian cancer. Between Jan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9601
更新日期:2019-01-01 00:00:00
abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.603
更新日期:2012-05-01 00:00:00
abstract::Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7256
更新日期:2017-12-01 00:00:00
abstract::Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves an important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression of RACK1 in gastric cancer (GC), and its association with the occurrence and development of GC. In ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6741
更新日期:2017-10-01 00:00:00
abstract::The aim of the present study was to evaluate the utility of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis of common renal tumors. Conventional magnetic resonance imaging and DWI were performed on 85 patients with renal lesions (54 renal carcinoma and 31 renal angiomyolipoma cases). The apparent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3605
更新日期:2015-10-01 00:00:00