abstract：BACKGROUND:There is major concern about the impact of the global COVID-19 outbreak on mental health. Several studies suggest that mental health deteriorated in many countries before and during enforced isolation (ie, lockdown), but it remains unknown how mental health has changed week by week over the course of the COV...

journal_title：The lancet. Psychiatry

authors： Fancourt D,Steptoe A,Bu F

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:People living in group situations or with dementia are more vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older people and those with multimorbidity have higher mortality if they become infected than the general population. However, no systematic study exists of C...

journal_title：The lancet. Psychiatry

authors： Livingston G,Rostamipour H,Gallagher P,Kalafatis C,Shastri A,Huzzey L,Liu K,Sommerlad A,Marston L

更新日期：2020-12-01 00:00:00

abstract：:High-quality data on funding for mental health research are essential to mapping funding levels, identifying gaps in the funding landscape, and tracking the impact of research funding. To date, quantitative analyses of research funding in mental health have been restricted in scope. In this Health Policy paper, we pre...

journal_title：The lancet. Psychiatry

authors： Woelbert E,Lundell-Smith K,White R,Kemmer D

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures. METHODS:Using Swedish national registers, we linked data on dispensed statin prescriptions with data o...

journal_title：The lancet. Psychiatry

authors： Molero Y,Cipriani A,Larsson H,Lichtenstein P,D'Onofrio BM,Fazel S

更新日期：2020-11-01 00:00:00

abstract：:The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health e...

journal_title：The lancet. Psychiatry

authors： Moreno C,Wykes T,Galderisi S,Nordentoft M,Crossley N,Jones N,Cannon M,Correll CU,Byrne L,Carr S,Chen EYH,Gorwood P,Johnson S,Kärkkäinen H,Krystal JH,Lee J,Lieberman J,López-Jaramillo C,Männikkö M,Phillips MR,Uchid

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. METHODS:We did an international online survey in French, German,...

journal_title：The lancet. Psychiatry

authors： Chevance A,Ravaud P,Tomlinson A,Le Berre C,Teufer B,Touboul S,Fried EI,Gartlehner G,Cipriani A,Tran VT

更新日期：2020-08-01 00:00:00

abstract：:The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover,...

journal_title：The lancet. Psychiatry

authors： Luza S,Opazo CM,Bousman CA,Pantelis C,Bush AI,Everall IP

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Several small studies suggest that the adjunctive use of anti-inflammatory agents might improve depressive symptoms in bipolar disorder. However, there are few well designed, appropriately powered clinical trials assessing the efficacy of these novel treatment strategies. We aimed to assess the efficacy of a...

journal_title：The lancet. Psychiatry

authors： Husain MI,Chaudhry IB,Khoso AB,Husain MO,Hodsoll J,Ansari MA,Naqvi HA,Minhas FA,Carvalho AF,Meyer JH,Deakin B,Mulsant BH,Husain N,Young AH

更新日期：2020-06-01 00:00:00

abstract：:Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients. This Personal...

journal_title：The lancet. Psychiatry

authors： Carnegie R,Zheng J,Sallis HM,Jones HJ,Wade KH,Evans J,Zammit S,Munafò MR,Martin RM

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Use of involuntary psychiatric hospitalisation varies widely within and between countries. The factors that place individuals and populations at increased risk of involuntary hospitalisation are unclear, and evidence is needed to understand these disparities and inform development of interventions to reduce ...

journal_title：The lancet. Psychiatry

authors： Walker S,Mackay E,Barnett P,Sheridan Rains L,Leverton M,Dalton-Locke C,Trevillion K,Lloyd-Evans B,Johnson S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Suicidal ideation due to abortion has been used to justify restrictive US abortion policies. Much research examining abortion and mental health has relied on self-report, has had low participation rates, and did not consider confounding factors. In the present study, we used data that do not rely on self-rep...

journal_title：The lancet. Psychiatry

authors： Steinberg JR,Laursen TM,Adler NE,Gasse C,Agerbo E,Munk-Olsen T

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of self-harm, and variations in area-level socioeconomic deprivation, and estimated the incidence of sui...

journal_title：The lancet. Psychiatry

authors： Geulayov G,Casey D,Bale L,Brand F,Clements C,Farooq B,Kapur N,Ness J,Waters K,Tsiachristas A,Hawton K

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Housing First is increasingly implemented for homeless adults with mental illness in large urban centres, but little is known about its long-term effectiveness. The At Home/Chez Soi randomised controlled trial done in five cities in Canada showed that Housing First improved housing stability and other select...

journal_title：The lancet. Psychiatry

authors： Stergiopoulos V,Mejia-Lancheros C,Nisenbaum R,Wang R,Lachaud J,O'Campo P,Hwang SW

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Substantial evidence suggests that cognitive deficits might persist after remission of a major depressive episode. However, results are inconsistent relative to the importance, pattern, severity, and moderating factors of this impairment. We aimed to determine how cognitive function following a major depress...

journal_title：The lancet. Psychiatry

authors： Semkovska M,Quinlivan L,O'Grady T,Johnson R,Collins A,O'Connor J,Knittle H,Ahern E,Gload T

更新日期：2019-10-01 00:00:00

abstract：:The care of people with first-episode mania has been overlooked in comparison with the care of patients with other non-affective psychoses, despite evidence suggesting targeted treatments might be of benefit for this patient group. In this Personal View, we outline the general epidemiology of first-episode mania in th...

journal_title：The lancet. Psychiatry

authors： Jauhar S,Ratheesh A,Davey C,Yatham LN,McGorry PD,McGuire P,Berk M,Young AH

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Many people with dementia living in care homes have distressing and costly agitation symptoms. Interventions should be efficacious, scalable, and feasible. METHODS:We did a parallel-group, cluster-randomised controlled trial in 20 care homes across England. Care homes were eligible if they had 17 residents ...

journal_title：The lancet. Psychiatry

authors： Livingston G,Barber J,Marston L,Stringer A,Panca M,Hunter R,Cooper C,Laybourne A,La Frenais F,Reeves S,Manela M,Lambe K,Banerjee S,Rapaport P

更新日期：2019-04-01 00:00:00

abstract：:This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of whic...

journal_title：The lancet. Psychiatry

authors： Wolpert M,Dalzell K,Ullman R,Garland L,Cortina M,Hayes D,Patalay P,Law D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Compulsory community treatment (CCT) aims to reduce hospital readmissions among people with mental illness. However, research examining the usefulness of CCT is inconclusive. We aimed to assess the effectiveness of CCT in reducing readmission and length of stay in hospital and increasing community service us...

journal_title：The lancet. Psychiatry

authors： Barnett P,Matthews H,Lloyd-Evans B,Mackay E,Pilling S,Johnson S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in child...

journal_title：The lancet. Psychiatry

authors： Cortese S,Adamo N,Del Giovane C,Mohr-Jensen C,Hayes AJ,Carucci S,Atkinson LZ,Tessari L,Banaschewski T,Coghill D,Hollis C,Simonoff E,Zuddas A,Barbui C,Purgato M,Steinhausen HC,Shokraneh F,Xia J,Cipriani A

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Exercise is known to be associated with reduced risk of all-cause mortality, cardiovascular disease, stroke, and diabetes, but its association with mental health remains unclear. We aimed to examine the association between exercise and mental health burden in a large sample, and to better understand the infl...

journal_title：The lancet. Psychiatry

authors： Chekroud SR,Gueorguieva R,Zheutlin AB,Paulus M,Krumholz HM,Krystal JH,Chekroud AM

更新日期：2018-09-01 00:00:00

abstract：:South Africa witnessed a national tragedy between October, 2015, and June, 2016, when the Department of Health in Gauteng province moved 1711 mental health-care users with severe mental illness or severe and profound intellectual disability out of facilities managed by a private company, Life Esidimeni, mainly into th...

journal_title：The lancet. Psychiatry

authors： Freeman MC

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30-40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to determine whether cognitive behavioural therapy (CBT) is an effective t...

journal_title：The lancet. Psychiatry

authors： Morrison AP,Pyle M,Gumley A,Schwannauer M,Turkington D,MacLennan G,Norrie J,Hudson J,Bowe SE,French P,Byrne R,Syrett S,Dudley R,McLeod HJ,Griffiths H,Barnes TRE,Davies L,Kingdon D,FOCUS trial group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort ...

journal_title：The lancet. Psychiatry

authors： Harvey SB,Sellahewa DA,Wang MJ,Milligan-Saville J,Bryan BT,Henderson M,Hatch SL,Mykletun A

更新日期：2018-06-01 00:00:00

abstract：:Mental health has been included in the UN Sustainable Development Goals. However, uncertainty exists about the extent to which the major social determinants of mental disorders are addressed by these goals. The aim of this study was to develop a conceptual framework for the social determinants of mental disorders that...

journal_title：The lancet. Psychiatry

authors： Lund C,Brooke-Sumner C,Baingana F,Baron EC,Breuer E,Chandra P,Haushofer J,Herrman H,Jordans M,Kieling C,Medina-Mora ME,Morgan E,Omigbodun O,Tol W,Patel V,Saxena S

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Self-harm in adolescents is common and repetition occurs in a high proportion of these cases. Scarce evidence exists for effectiveness of interventions to reduce self-harm. METHODS:This pragmatic, multicentre, randomised, controlled trial of family therapy versus treatment as usual was done at 40 UK Child a...

journal_title：The lancet. Psychiatry

authors： Cottrell DJ,Wright-Hughes A,Collinson M,Boston P,Eisler I,Fortune S,Graham EH,Green J,House AO,Kerfoot M,Owens DW,Saloniki EC,Simic M,Lambert F,Rothwell J,Tubeuf S,Farrin AJ

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems with social functioning. We aimed to assess the efficacy of early intervention services augmented with social r...

journal_title：The lancet. Psychiatry

authors： Fowler D,Hodgekins J,French P,Marshall M,Freemantle N,McCrone P,Everard L,Lavis A,Jones PB,Amos T,Singh S,Sharma V,Birchwood M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the ...

journal_title：The lancet. Psychiatry

authors： Schönenberg M,Wiedemann E,Schneidt A,Scheeff J,Logemann A,Keune PM,Hautzinger M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS:In a ...

journal_title：The lancet. Psychiatry

authors： Schoeler T,Petros N,Di Forti M,Klamerus E,Foglia E,Murray R,Bhattacharyya S

更新日期：2017-08-01 00:00:00

abstract：:Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisat...

journal_title：The lancet. Psychiatry

authors： Englund A,Freeman TP,Murray RM,McGuire P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Smoke-free policies are important to protect health and reduce health inequalities. A major barrier to policy implementation in psychiatric hospitals is staff concern that physical violence will increase. We aimed to assess the effect of implementing a comprehensive smoke-free policy on rates of physical ass...

journal_title：The lancet. Psychiatry

authors： Robson D,Spaducci G,McNeill A,Stewart D,Craig TJK,Yates M,Szatkowski L

更新日期：2017-07-01 00:00:00

abstract：:Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach. First, we discuss what...

journal_title：The lancet. Psychiatry

authors： Thapar A,Cooper M,Rutter M

更新日期：2017-04-01 00:00:00

abstract：:Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cau...

journal_title：The lancet. Psychiatry

authors： Radhakrishnan R,Garakani A,Gross LS,Goin MK,Pine J,Slaby AE,Sumner CR,Baron DA

更新日期：2016-12-01 00:00:00

abstract：:More than 10 million people are imprisoned worldwide, and the prevalence of all investigated mental disorders is higher in prisoners than in the general population. Although the extent to which prison increases the incidence of mental disorders is uncertain, considerable evidence suggests low rates of identification a...

journal_title：The lancet. Psychiatry

authors： Fazel S,Hayes AJ,Bartellas K,Clerici M,Trestman R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The conceptualisation of transgender identity as a mental disorder has contributed to precarious legal status, human rights violations, and barriers to appropriate health care among transgender people. The proposed reconceptualisation of categories related to transgender identity in WHO's forthcoming Interna...

journal_title：The lancet. Psychiatry

authors： Robles R,Fresán A,Vega-Ramírez H,Cruz-Islas J,Rodríguez-Pérez V,Domínguez-Martínez T,Reed GM

更新日期：2016-09-01 00:00:00

abstract：:Suicide is the 15th leading cause of death worldwide, with over 75% of suicides occurring in low-income and middle-income countries. Nonetheless, evidence on the association between suicide and poverty in low-income and middle-income countries is scarce. We did a systematic review to understand the association between...

journal_title：The lancet. Psychiatry

authors： Iemmi V,Bantjes J,Coast E,Channer K,Leone T,McDaid D,Palfreyman A,Stephens B,Lund C

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the compl...

journal_title：The lancet. Psychiatry

authors： Mirza SS,Wolters FJ,Swanson SA,Koudstaal PJ,Hofman A,Tiemeier H,Ikram MA

更新日期：2016-07-01 00:00:00

abstract：:A spectrum of severity of paranoia (unfounded thoughts that others are deliberately intending to cause harm) exists within the general population. This is unsurprising: deciding whether to trust or mistrust is a vital aspect of human cognition, but accurate judgment of others' intentions is challenging. The severest f...

journal_title：The lancet. Psychiatry

authors： Freeman D

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:In view of the high co-occurrence of depression and insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia intervention. We aimed to assess whether an online self-help insomnia program could reduce depression symptoms. METHODS:We did this randomised controlled trial ...

journal_title：The lancet. Psychiatry

authors： Christensen H,Batterham PJ,Gosling JA,Ritterband LM,Griffiths KM,Thorndike FP,Glozier N,O'Dea B,Hickie IB,Mackinnon AJ

更新日期：2016-04-01 00:00:00

abstract：:Substance use in young people (aged 10-24 years) might disrupt key periods of transition that occur as the adolescent brain undergoes cognitive and emotional development, and key psychosocial transitions are made. Adolescence is the peak time for initiation of substance use, with tobacco and alcohol usually preceding ...

journal_title：The lancet. Psychiatry

authors： Degenhardt L,Stockings E,Patton G,Hall WD,Lynskey M

更新日期：2016-03-01 00:00:00

abstract：:We argue that the global burden of mental illness is underestimated and examine the reasons for under-estimation to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskele...

journal_title：The lancet. Psychiatry

authors： Vigo D,Thornicroft G,Atun R

更新日期：2016-02-01 00:00:00