Neurodevelopmental disorders.

abstract：BACKGROUND:Use of involuntary psychiatric hospitalisation varies widely within and between countries. The factors that place individuals and populations at increased risk of involuntary hospitalisation are unclear, and evidence is needed to understand these disparities and inform development of interventions to reduce ...

journal_title：The lancet. Psychiatry

authors： Walker S,Mackay E,Barnett P,Sheridan Rains L,Leverton M,Dalton-Locke C,Trevillion K,Lloyd-Evans B,Johnson S

更新日期：2019-12-01 00:00:00

abstract：:The aim of this Review is to identify effective interventions and treatment guidelines to manage common types of psychiatric emergencies in non-specialist settings in low-income and middle-income countries. Mental health specialist services in low-income and middle-income countries are scarce. We did a systematic revi...

journal_title：The lancet. Psychiatry

authors： Nadkarni A,Hanlon C,Bhatia U,Fuhr D,Ragoni C,de Azevedo Perocco SL,Fortes S,Shidhaye R,Kinyanda E,Rangaswamy T,Patel V

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of self-harm, and variations in area-level socioeconomic deprivation, and estimated the incidence of sui...

journal_title：The lancet. Psychiatry

authors： Geulayov G,Casey D,Bale L,Brand F,Clements C,Farooq B,Kapur N,Ness J,Waters K,Tsiachristas A,Hawton K

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Acting on command hallucinations in psychosis can have serious consequences for the individual and for other people and is a major cause of clinical and public concern. No evidence-based treatments are available to reduce this risk behaviour. We therefore tested our new cognitive therapy to challenge the per...

journal_title：The lancet. Psychiatry

authors： Birchwood M,Michail M,Meaden A,Tarrier N,Lewis S,Wykes T,Davies L,Dunn G,Peters E

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In high-income countries, maternal postnatal depression is associated with adverse outcomes in the child. However, few studies have investigated this relation in countries of low and middle income. Furthermore, to our knowledge, no studies have followed up cohorts into later childhood. We aimed to investigat...

journal_title：The lancet. Psychiatry

authors： Verkuijl NE,Richter L,Norris SA,Stein A,Avan B,Ramchandani PG

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Housing First is increasingly implemented for homeless adults with mental illness in large urban centres, but little is known about its long-term effectiveness. The At Home/Chez Soi randomised controlled trial done in five cities in Canada showed that Housing First improved housing stability and other select...

journal_title：The lancet. Psychiatry

authors： Stergiopoulos V,Mejia-Lancheros C,Nisenbaum R,Wang R,Lachaud J,O'Campo P,Hwang SW

更新日期：2019-11-01 00:00:00

abstract：:Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients. This Personal...

journal_title：The lancet. Psychiatry

authors： Carnegie R,Zheng J,Sallis HM,Jones HJ,Wade KH,Evans J,Zammit S,Munafò MR,Martin RM

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:There is major concern about the impact of the global COVID-19 outbreak on mental health. Several studies suggest that mental health deteriorated in many countries before and during enforced isolation (ie, lockdown), but it remains unknown how mental health has changed week by week over the course of the COV...

journal_title：The lancet. Psychiatry

authors： Fancourt D,Steptoe A,Bu F

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:With a lifetime risk for major depressive disorder of up to 50%, depression is a common comorbidity in multiple sclerosis but remains widely underdiagnosed and untreated. We investigated the potential of a fully automated, internet-based, cognitive behavioural therapy programme, Deprexis, to reduce depressiv...

journal_title：The lancet. Psychiatry

authors： Fischer A,Schröder J,Vettorazzi E,Wolf OT,Pöttgen J,Lau S,Heesen C,Moritz S,Gold SM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems with social functioning. We aimed to assess the efficacy of early intervention services augmented with social r...

journal_title：The lancet. Psychiatry

authors： Fowler D,Hodgekins J,French P,Marshall M,Freemantle N,McCrone P,Everard L,Lavis A,Jones PB,Amos T,Singh S,Sharma V,Birchwood M

更新日期：2018-01-01 00:00:00

abstract：:Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of ...

journal_title：The lancet. Psychiatry

authors： Lai MC,Baron-Cohen S

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Depressive symptoms are a major cause of disability in bipolar disorder and there are few safe and effective treatments. The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. We aimed to determine if combination therapy with quetiapine plus la...

journal_title：The lancet. Psychiatry

authors： Geddes JR,Gardiner A,Rendell J,Voysey M,Tunbridge E,Hinds C,Yu LM,Hainsworth J,Attenburrow MJ,Simon J,Goodwin GM,Harrison PJ,CEQUEL Investigators and Collaborators.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Self-harm in adolescents is common and repetition occurs in a high proportion of these cases. Scarce evidence exists for effectiveness of interventions to reduce self-harm. METHODS:This pragmatic, multicentre, randomised, controlled trial of family therapy versus treatment as usual was done at 40 UK Child a...

journal_title：The lancet. Psychiatry

authors： Cottrell DJ,Wright-Hughes A,Collinson M,Boston P,Eisler I,Fortune S,Graham EH,Green J,House AO,Kerfoot M,Owens DW,Saloniki EC,Simic M,Lambert F,Rothwell J,Tubeuf S,Farrin AJ

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population; however, no meta-analysis has provided prevalence data within and between syndromes. In this systematic review and meta-analysis, we aimed to synthesise data f...

journal_title：The lancet. Psychiatry

authors： Richards C,Jones C,Groves L,Moss J,Oliver C

更新日期：2015-10-01 00:00:00

abstract：:Substance use in young people (aged 10-24 years) might disrupt key periods of transition that occur as the adolescent brain undergoes cognitive and emotional development, and key psychosocial transitions are made. Adolescence is the peak time for initiation of substance use, with tobacco and alcohol usually preceding ...

journal_title：The lancet. Psychiatry

authors： Degenhardt L,Stockings E,Patton G,Hall WD,Lynskey M

更新日期：2016-03-01 00:00:00

abstract：:Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisat...

journal_title：The lancet. Psychiatry

authors： Englund A,Freeman TP,Murray RM,McGuire P

更新日期：2017-08-01 00:00:00

abstract：:The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health e...

journal_title：The lancet. Psychiatry

authors： Moreno C,Wykes T,Galderisi S,Nordentoft M,Crossley N,Jones N,Cannon M,Correll CU,Byrne L,Carr S,Chen EYH,Gorwood P,Johnson S,Kärkkäinen H,Krystal JH,Lee J,Lieberman J,López-Jaramillo C,Männikkö M,Phillips MR,Uchid

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Social anxiety disorder-a chronic and naturally unremitting disease that causes substantial impairment-can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety di...

journal_title：The lancet. Psychiatry

authors： Mayo-Wilson E,Dias S,Mavranezouli I,Kew K,Clark DM,Ades AE,Pilling S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Several small studies suggest that the adjunctive use of anti-inflammatory agents might improve depressive symptoms in bipolar disorder. However, there are few well designed, appropriately powered clinical trials assessing the efficacy of these novel treatment strategies. We aimed to assess the efficacy of a...

journal_title：The lancet. Psychiatry

authors： Husain MI,Chaudhry IB,Khoso AB,Husain MO,Hodsoll J,Ansari MA,Naqvi HA,Minhas FA,Carvalho AF,Meyer JH,Deakin B,Mulsant BH,Husain N,Young AH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Exercise is known to be associated with reduced risk of all-cause mortality, cardiovascular disease, stroke, and diabetes, but its association with mental health remains unclear. We aimed to examine the association between exercise and mental health burden in a large sample, and to better understand the infl...

journal_title：The lancet. Psychiatry

authors： Chekroud SR,Gueorguieva R,Zheutlin AB,Paulus M,Krumholz HM,Krystal JH,Chekroud AM

更新日期：2018-09-01 00:00:00

abstract：:This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of whic...

journal_title：The lancet. Psychiatry

authors： Wolpert M,Dalzell K,Ullman R,Garland L,Cortina M,Hayes D,Patalay P,Law D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In view of the high co-occurrence of depression and insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia intervention. We aimed to assess whether an online self-help insomnia program could reduce depression symptoms. METHODS:We did this randomised controlled trial ...

journal_title：The lancet. Psychiatry

authors： Christensen H,Batterham PJ,Gosling JA,Ritterband LM,Griffiths KM,Thorndike FP,Glozier N,O'Dea B,Hickie IB,Mackinnon AJ

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in child...

journal_title：The lancet. Psychiatry

authors： Cortese S,Adamo N,Del Giovane C,Mohr-Jensen C,Hayes AJ,Carucci S,Atkinson LZ,Tessari L,Banaschewski T,Coghill D,Hollis C,Simonoff E,Zuddas A,Barbui C,Purgato M,Steinhausen HC,Shokraneh F,Xia J,Cipriani A

更新日期：2018-09-01 00:00:00

abstract：:The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover,...

journal_title：The lancet. Psychiatry

authors： Luza S,Opazo CM,Bousman CA,Pantelis C,Bush AI,Everall IP

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort ...

journal_title：The lancet. Psychiatry

authors： Harvey SB,Sellahewa DA,Wang MJ,Milligan-Saville J,Bryan BT,Henderson M,Hatch SL,Mykletun A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom c...

journal_title：The lancet. Psychiatry

authors： Hoge CW,Riviere LA,Wilk JE,Herrell RK,Weathers FW

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30-40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to determine whether cognitive behavioural therapy (CBT) is an effective t...

journal_title：The lancet. Psychiatry

authors： Morrison AP,Pyle M,Gumley A,Schwannauer M,Turkington D,MacLennan G,Norrie J,Hudson J,Bowe SE,French P,Byrne R,Syrett S,Dudley R,McLeod HJ,Griffiths H,Barnes TRE,Davies L,Kingdon D,FOCUS trial group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. METHODS:We did an international online survey in French, German,...

journal_title：The lancet. Psychiatry

authors： Chevance A,Ravaud P,Tomlinson A,Le Berre C,Teufer B,Touboul S,Fried EI,Gartlehner G,Cipriani A,Tran VT

更新日期：2020-08-01 00:00:00

abstract：:More than 10 million people are imprisoned worldwide, and the prevalence of all investigated mental disorders is higher in prisoners than in the general population. Although the extent to which prison increases the incidence of mental disorders is uncertain, considerable evidence suggests low rates of identification a...

journal_title：The lancet. Psychiatry

authors： Fazel S,Hayes AJ,Bartellas K,Clerici M,Trestman R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The PACE trial found that, when added to specialist medical care (SMC), cognitive behavioural therapy (CBT), or graded exercise therapy (GET) were superior to adaptive pacing therapy (APT) or SMC alone in improving fatigue and physical functioning in people with chronic fatigue syndrome 1 year after randomis...

journal_title：The lancet. Psychiatry

authors： Sharpe M,Goldsmith KA,Johnson AL,Chalder T,Walker J,White PD

更新日期：2015-12-01 00:00:00