The ubiquitin proteasome system and schizophrenia.

abstract：BACKGROUND:People living in group situations or with dementia are more vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older people and those with multimorbidity have higher mortality if they become infected than the general population. However, no systematic study exists of C...

journal_title：The lancet. Psychiatry

authors： Livingston G,Rostamipour H,Gallagher P,Kalafatis C,Shastri A,Huzzey L,Liu K,Sommerlad A,Marston L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Compulsory community treatment (CCT) aims to reduce hospital readmissions among people with mental illness. However, research examining the usefulness of CCT is inconclusive. We aimed to assess the effectiveness of CCT in reducing readmission and length of stay in hospital and increasing community service us...

journal_title：The lancet. Psychiatry

authors： Barnett P,Matthews H,Lloyd-Evans B,Mackay E,Pilling S,Johnson S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom c...

journal_title：The lancet. Psychiatry

authors： Hoge CW,Riviere LA,Wilk JE,Herrell RK,Weathers FW

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30-40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to determine whether cognitive behavioural therapy (CBT) is an effective t...

journal_title：The lancet. Psychiatry

authors： Morrison AP,Pyle M,Gumley A,Schwannauer M,Turkington D,MacLennan G,Norrie J,Hudson J,Bowe SE,French P,Byrne R,Syrett S,Dudley R,McLeod HJ,Griffiths H,Barnes TRE,Davies L,Kingdon D,FOCUS trial group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort ...

journal_title：The lancet. Psychiatry

authors： Harvey SB,Sellahewa DA,Wang MJ,Milligan-Saville J,Bryan BT,Henderson M,Hatch SL,Mykletun A

更新日期：2018-06-01 00:00:00

abstract：:South Africa witnessed a national tragedy between October, 2015, and June, 2016, when the Department of Health in Gauteng province moved 1711 mental health-care users with severe mental illness or severe and profound intellectual disability out of facilities managed by a private company, Life Esidimeni, mainly into th...

journal_title：The lancet. Psychiatry

authors： Freeman MC

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Acting on command hallucinations in psychosis can have serious consequences for the individual and for other people and is a major cause of clinical and public concern. No evidence-based treatments are available to reduce this risk behaviour. We therefore tested our new cognitive therapy to challenge the per...

journal_title：The lancet. Psychiatry

authors： Birchwood M,Michail M,Meaden A,Tarrier N,Lewis S,Wykes T,Davies L,Dunn G,Peters E

更新日期：2014-06-01 00:00:00

abstract：:Suicide is the 15th leading cause of death worldwide, with over 75% of suicides occurring in low-income and middle-income countries. Nonetheless, evidence on the association between suicide and poverty in low-income and middle-income countries is scarce. We did a systematic review to understand the association between...

journal_title：The lancet. Psychiatry

authors： Iemmi V,Bantjes J,Coast E,Channer K,Leone T,McDaid D,Palfreyman A,Stephens B,Lund C

更新日期：2016-08-01 00:00:00

abstract：:This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of whic...

journal_title：The lancet. Psychiatry

authors： Wolpert M,Dalzell K,Ullman R,Garland L,Cortina M,Hayes D,Patalay P,Law D

更新日期：2019-01-01 00:00:00

abstract：:The aim of this Review is to identify effective interventions and treatment guidelines to manage common types of psychiatric emergencies in non-specialist settings in low-income and middle-income countries. Mental health specialist services in low-income and middle-income countries are scarce. We did a systematic revi...

journal_title：The lancet. Psychiatry

authors： Nadkarni A,Hanlon C,Bhatia U,Fuhr D,Ragoni C,de Azevedo Perocco SL,Fortes S,Shidhaye R,Kinyanda E,Rangaswamy T,Patel V

更新日期：2015-06-01 00:00:00

abstract：:We argue that the global burden of mental illness is underestimated and examine the reasons for under-estimation to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskele...

journal_title：The lancet. Psychiatry

authors： Vigo D,Thornicroft G,Atun R

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. METHODS:We did an international online survey in French, German,...

journal_title：The lancet. Psychiatry

authors： Chevance A,Ravaud P,Tomlinson A,Le Berre C,Teufer B,Touboul S,Fried EI,Gartlehner G,Cipriani A,Tran VT

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Early social deprivation can negatively affect domains of functioning. We examined psychopathology at age 12 years in a cohort of Romanian children who had been abandoned at birth and placed into institutional care, then assigned either to be placed in foster care or to care as usual. METHODS:We used follow...

journal_title：The lancet. Psychiatry

authors： Humphreys KL,Gleason MM,Drury SS,Miron D,Nelson CA 3rd,Fox NA,Zeanah CH

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The first episode of psychosis is a crucial period when early intervention can alter the trajectory of the young person's ongoing mental health and general functioning. After an investigation into completed suicides in the Early Psychosis Prevention and Intervention Centre (EPPIC) programme, the intensive ca...

journal_title：The lancet. Psychiatry

authors： Brewer WJ,Lambert TJ,Witt K,Dileo J,Duff C,Crlenjak C,McGorry PD,Murphy BP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In high-income countries, maternal postnatal depression is associated with adverse outcomes in the child. However, few studies have investigated this relation in countries of low and middle income. Furthermore, to our knowledge, no studies have followed up cohorts into later childhood. We aimed to investigat...

journal_title：The lancet. Psychiatry

authors： Verkuijl NE,Richter L,Norris SA,Stein A,Avan B,Ramchandani PG

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Social anxiety disorder-a chronic and naturally unremitting disease that causes substantial impairment-can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety di...

journal_title：The lancet. Psychiatry

authors： Mayo-Wilson E,Dias S,Mavranezouli I,Kew K,Clark DM,Ades AE,Pilling S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Anxiety in children is common, impairs everyday functioning, and increases the risk of severe mental health disorders in adulthood. We investigated the effect of a classroom-based cognitive behaviour therapy prevention programme (FRIENDS) on anxiety symptoms in children. METHODS:Preventing Anxiety in Childr...

journal_title：The lancet. Psychiatry

authors： Stallard P,Skryabina E,Taylor G,Phillips R,Daniels H,Anderson R,Simpson N

更新日期：2014-08-01 00:00:00

abstract：:The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health e...

journal_title：The lancet. Psychiatry

authors： Moreno C,Wykes T,Galderisi S,Nordentoft M,Crossley N,Jones N,Cannon M,Correll CU,Byrne L,Carr S,Chen EYH,Gorwood P,Johnson S,Kärkkäinen H,Krystal JH,Lee J,Lieberman J,López-Jaramillo C,Männikkö M,Phillips MR,Uchid

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Suicidal ideation due to abortion has been used to justify restrictive US abortion policies. Much research examining abortion and mental health has relied on self-report, has had low participation rates, and did not consider confounding factors. In the present study, we used data that do not rely on self-rep...

journal_title：The lancet. Psychiatry

authors： Steinberg JR,Laursen TM,Adler NE,Gasse C,Agerbo E,Munk-Olsen T

更新日期：2019-12-01 00:00:00

abstract：:Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics res...

journal_title：The lancet. Psychiatry

authors： Stephan KE,Bach DR,Fletcher PC,Flint J,Frank MJ,Friston KJ,Heinz A,Huys QJM,Owen MJ,Binder EB,Dayan P,Johnstone EC,Meyer-Lindenberg A,Montague PR,Schnyder U,Wang XJ,Breakspear M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems with social functioning. We aimed to assess the efficacy of early intervention services augmented with social r...

journal_title：The lancet. Psychiatry

authors： Fowler D,Hodgekins J,French P,Marshall M,Freemantle N,McCrone P,Everard L,Lavis A,Jones PB,Amos T,Singh S,Sharma V,Birchwood M

更新日期：2018-01-01 00:00:00

abstract：:A spectrum of severity of paranoia (unfounded thoughts that others are deliberately intending to cause harm) exists within the general population. This is unsurprising: deciding whether to trust or mistrust is a vital aspect of human cognition, but accurate judgment of others' intentions is challenging. The severest f...

journal_title：The lancet. Psychiatry

authors： Freeman D

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in child...

journal_title：The lancet. Psychiatry

authors： Cortese S,Adamo N,Del Giovane C,Mohr-Jensen C,Hayes AJ,Carucci S,Atkinson LZ,Tessari L,Banaschewski T,Coghill D,Hollis C,Simonoff E,Zuddas A,Barbui C,Purgato M,Steinhausen HC,Shokraneh F,Xia J,Cipriani A

更新日期：2018-09-01 00:00:00

abstract：:Substance use in young people (aged 10-24 years) might disrupt key periods of transition that occur as the adolescent brain undergoes cognitive and emotional development, and key psychosocial transitions are made. Adolescence is the peak time for initiation of substance use, with tobacco and alcohol usually preceding ...

journal_title：The lancet. Psychiatry

authors： Degenhardt L,Stockings E,Patton G,Hall WD,Lynskey M

更新日期：2016-03-01 00:00:00

abstract：:More than 10 million people are imprisoned worldwide, and the prevalence of all investigated mental disorders is higher in prisoners than in the general population. Although the extent to which prison increases the incidence of mental disorders is uncertain, considerable evidence suggests low rates of identification a...

journal_title：The lancet. Psychiatry

authors： Fazel S,Hayes AJ,Bartellas K,Clerici M,Trestman R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the ...

journal_title：The lancet. Psychiatry

authors： Schönenberg M,Wiedemann E,Schneidt A,Scheeff J,Logemann A,Keune PM,Hautzinger M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Several small studies suggest that the adjunctive use of anti-inflammatory agents might improve depressive symptoms in bipolar disorder. However, there are few well designed, appropriately powered clinical trials assessing the efficacy of these novel treatment strategies. We aimed to assess the efficacy of a...

journal_title：The lancet. Psychiatry

authors： Husain MI,Chaudhry IB,Khoso AB,Husain MO,Hodsoll J,Ansari MA,Naqvi HA,Minhas FA,Carvalho AF,Meyer JH,Deakin B,Mulsant BH,Husain N,Young AH

更新日期：2020-06-01 00:00:00

abstract：:High-quality data on funding for mental health research are essential to mapping funding levels, identifying gaps in the funding landscape, and tracking the impact of research funding. To date, quantitative analyses of research funding in mental health have been restricted in scope. In this Health Policy paper, we pre...

journal_title：The lancet. Psychiatry

authors： Woelbert E,Lundell-Smith K,White R,Kemmer D

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) added to specialist medical care (SMC), or graded exercise therapy (GET) added to SMC, are more effective in reducing fatigue and improving physical function than both adaptive pacing therapy (APT) plus SMC and SMC alone for chronic fatigue syndrome. We investigate putative ...

journal_title：The lancet. Psychiatry

authors： Chalder T,Goldsmith KA,White PD,Sharpe M,Pickles AR

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures. METHODS:Using Swedish national registers, we linked data on dispensed statin prescriptions with data o...

journal_title：The lancet. Psychiatry

authors： Molero Y,Cipriani A,Larsson H,Lichtenstein P,D'Onofrio BM,Fazel S

更新日期：2020-11-01 00:00:00