Abstract:
:Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics research have yet to affect disease definitions or contribute to clinical decision making. In this challenging setting, what should psychiatric research focus on? In two companion papers, we present a list of problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this Personal View) and problems related to pathogenesis and aetiology (in the companion Personal View). Motivated by successful examples in other disciplines, particularly the list of Hilbert's problems in mathematics, this subjective and eclectic list of priority problems is intended for psychiatric researchers, helping to re-focus existing research and providing perspectives for future psychiatric science.
journal_name
Lancet Psychiatryjournal_title
The lancet. Psychiatryauthors
Stephan KE,Bach DR,Fletcher PC,Flint J,Frank MJ,Friston KJ,Heinz A,Huys QJM,Owen MJ,Binder EB,Dayan P,Johnstone EC,Meyer-Lindenberg A,Montague PR,Schnyder U,Wang XJ,Breakspear Mdoi
10.1016/S2215-0366(15)00361-2subject
Has Abstractpub_date
2016-01-01 00:00:00pages
77-83issue
1eissn
2215-0366issn
2215-0374pii
S2215-0366(15)00361-2journal_volume
3pub_type
杂志文章,评审abstract:BACKGROUND:Exercise is known to be associated with reduced risk of all-cause mortality, cardiovascular disease, stroke, and diabetes, but its association with mental health remains unclear. We aimed to examine the association between exercise and mental health burden in a large sample, and to better understand the infl...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(18)30227-X
更新日期:2018-09-01 00:00:00
abstract::Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cau...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(16)30266-8
更新日期:2016-12-01 00:00:00
abstract::Mental health has been included in the UN Sustainable Development Goals. However, uncertainty exists about the extent to which the major social determinants of mental disorders are addressed by these goals. The aim of this study was to develop a conceptual framework for the social determinants of mental disorders that...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(18)30060-9
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Smoke-free policies are important to protect health and reduce health inequalities. A major barrier to policy implementation in psychiatric hospitals is staff concern that physical violence will increase. We aimed to assess the effect of implementing a comprehensive smoke-free policy on rates of physical ass...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(17)30209-2
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Compulsory community treatment (CCT) aims to reduce hospital readmissions among people with mental illness. However, research examining the usefulness of CCT is inconclusive. We aimed to assess the effectiveness of CCT in reducing readmission and length of stay in hospital and increasing community service us...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,meta分析
doi:10.1016/S2215-0366(18)30382-1
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Adults with intellectual disabilities have substantial health inequalities and poor access to health care. We assessed whether practice nurse-delivered health checks could improve the health of adults with intellectual disabilities compared with standard care. METHODS:In this cluster-design, single-blind, r...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(14)00078-9
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:In high-income countries, maternal postnatal depression is associated with adverse outcomes in the child. However, few studies have investigated this relation in countries of low and middle income. Furthermore, to our knowledge, no studies have followed up cohorts into later childhood. We aimed to investigat...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(14)70361-X
更新日期:2014-11-01 00:00:00
abstract::Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach. First, we discuss what...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(16)30376-5
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures. METHODS:Using Swedish national registers, we linked data on dispensed statin prescriptions with data o...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(20)30311-4
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The PACE trial found that, when added to specialist medical care (SMC), cognitive behavioural therapy (CBT), or graded exercise therapy (GET) were superior to adaptive pacing therapy (APT) or SMC alone in improving fatigue and physical functioning in people with chronic fatigue syndrome 1 year after randomis...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/S2215-0366(15)00317-X
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Self-harm in adolescents is common and repetition occurs in a high proportion of these cases. Scarce evidence exists for effectiveness of interventions to reduce self-harm. METHODS:This pragmatic, multicentre, randomised, controlled trial of family therapy versus treatment as usual was done at 40 UK Child a...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/S2215-0366(18)30058-0
更新日期:2018-03-01 00:00:00
abstract::The aim of this Review is to identify effective interventions and treatment guidelines to manage common types of psychiatric emergencies in non-specialist settings in low-income and middle-income countries. Mental health specialist services in low-income and middle-income countries are scarce. We did a systematic revi...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(15)00094-2
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the compl...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(16)00097-3
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The conceptualisation of transgender identity as a mental disorder has contributed to precarious legal status, human rights violations, and barriers to appropriate health care among transgender people. The proposed reconceptualisation of categories related to transgender identity in WHO's forthcoming Interna...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(16)30165-1
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the ...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/S2215-0366(17)30291-2
更新日期:2017-09-01 00:00:00
abstract::The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health e...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(20)30307-2
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population; however, no meta-analysis has provided prevalence data within and between syndromes. In this systematic review and meta-analysis, we aimed to synthesise data f...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1016/S2215-0366(15)00376-4
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of self-harm, and variations in area-level socioeconomic deprivation, and estimated the incidence of sui...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/S2215-0366(19)30402-X
更新日期:2019-12-01 00:00:00
abstract::Suicide is the 15th leading cause of death worldwide, with over 75% of suicides occurring in low-income and middle-income countries. Nonetheless, evidence on the association between suicide and poverty in low-income and middle-income countries is scarce. We did a systematic review to understand the association between...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(16)30066-9
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:In view of the high co-occurrence of depression and insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia intervention. We aimed to assess whether an online self-help insomnia program could reduce depression symptoms. METHODS:We did this randomised controlled trial ...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/S2215-0366(15)00536-2
更新日期:2016-04-01 00:00:00
abstract::This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of whic...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(18)30465-6
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom c...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(14)70235-4
更新日期:2014-09-01 00:00:00
abstract::Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisat...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(17)30075-5
更新日期:2017-08-01 00:00:00
abstract::Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of ...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(15)00277-1
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Social anxiety disorder-a chronic and naturally unremitting disease that causes substantial impairment-can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety di...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章
doi:10.1016/S2215-0366(14)70329-3
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Cognitive behaviour therapy (CBT) added to specialist medical care (SMC), or graded exercise therapy (GET) added to SMC, are more effective in reducing fatigue and improving physical function than both adaptive pacing therapy (APT) plus SMC and SMC alone for chronic fatigue syndrome. We investigate putative ...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/S2215-0366(14)00069-8
更新日期:2015-02-01 00:00:00
abstract::A spectrum of severity of paranoia (unfounded thoughts that others are deliberately intending to cause harm) exists within the general population. This is unsurprising: deciding whether to trust or mistrust is a vital aspect of human cognition, but accurate judgment of others' intentions is challenging. The severest f...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(16)00066-3
更新日期:2016-07-01 00:00:00
abstract::The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover,...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/S2215-0366(19)30520-6
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Early social deprivation can negatively affect domains of functioning. We examined psychopathology at age 12 years in a cohort of Romanian children who had been abandoned at birth and placed into institutional care, then assigned either to be placed in foster care or to care as usual. METHODS:We used follow...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/S2215-0366(15)00095-4
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Housing First is increasingly implemented for homeless adults with mental illness in large urban centres, but little is known about its long-term effectiveness. The At Home/Chez Soi randomised controlled trial done in five cities in Canada showed that Housing First improved housing stability and other select...
journal_title:The lancet. Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/S2215-0366(19)30371-2
更新日期:2019-11-01 00:00:00