Abstract：
:Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of the spectrum concept. Thus, the idea of a lost generation of people who were previously excluded from a diagnosis of classic autism has arisen. Making a first diagnosis of autism spectrum conditions in adults can be challenging for practical reasons (eg, no person to provide a developmental history), developmental reasons (eg, the acquisition of learnt or camouflaging strategies), and clinical reasons (eg, high frequency of co-occurring disorders). The diagnostic process includes referral, screening, interviews with informants and patients, and functional assessments. In delineating differential diagnoses, true comorbidities, and overlapping behaviour with other psychiatric diagnoses, particular attention should be paid to anxiety, depression, obsessive-compulsive disorder, psychosis, personality disorders, and other neurodevelopmental disorders. Possible misdiagnosis, especially in women, should be explored. The creation of supportive, accepting, and autism-friendly social and physical environments is important and requires a coordinated effort across agencies and needs support from government policies.
journal_name
Lancet Psychiatryjournal_title
The lancet. Psychiatryauthors
Lai MC,Baron-Cohen Sdoi
10.1016/S2215-0366(15)00277-1subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1013-27issue
11eissn
2215-0366issn
2215-0374pii
S2215-0366(15)00277-1journal_volume
2pub_type
杂志文章,评审abstract：BACKGROUND:Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of self-harm, and variations in area-level socioeconomic deprivation, and estimated the incidence of sui...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1016/S2215-0366(19)30402-X
更新日期：2019-12-01 00:00:00
abstract：:Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach. First, we discuss what...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(16)30376-5
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The benefits and safety of medications for attention-deficit hyperactivity disorder (ADHD) remain controversial, and guidelines are inconsistent on which medications are preferred across different age groups. We aimed to estimate the comparative efficacy and tolerability of oral medications for ADHD in child...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/S2215-0366(18)30269-4
更新日期：2018-09-01 00:00:00
abstract：:The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover,...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(19)30520-6
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Use of involuntary psychiatric hospitalisation varies widely within and between countries. The factors that place individuals and populations at increased risk of involuntary hospitalisation are unclear, and evidence is needed to understand these disparities and inform development of interventions to reduce ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/S2215-0366(19)30406-7
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Early social deprivation can negatively affect domains of functioning. We examined psychopathology at age 12 years in a cohort of Romanian children who had been abandoned at birth and placed into institutional care, then assigned either to be placed in foster care or to care as usual. METHODS:We used follow...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/S2215-0366(15)00095-4
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Cognitive behaviour therapy (CBT) added to specialist medical care (SMC), or graded exercise therapy (GET) added to SMC, are more effective in reducing fatigue and improving physical function than both adaptive pacing therapy (APT) plus SMC and SMC alone for chronic fatigue syndrome. We investigate putative ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/S2215-0366(14)00069-8
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom c...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(14)70235-4
更新日期：2014-09-01 00:00:00
abstract：:This Review reports on a scoping review followed by a systematic review to consider interventions designed to address or manage depression or anxiety in children and young people up to the age of 25 years without the need to involve mental health professionals. The scoping review identified 132 approaches, 103 of whic...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(18)30465-6
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Many people with dementia living in care homes have distressing and costly agitation symptoms. Interventions should be efficacious, scalable, and feasible. METHODS:We did a parallel-group, cluster-randomised controlled trial in 20 care homes across England. Care homes were eligible if they had 17 residents ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/S2215-0366(19)30045-8
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Many older adults with major depression, particularly veterans, do not have access to evidence-based psychotherapy. Telemedicine could increase access to best-practice care for older adults facing barriers of mobility, stigma, and geographical isolation. We aimed to establish non-inferiority of behavioural a...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/S2215-0366(15)00122-4
更新日期：2015-08-01 00:00:00
abstract：:Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisat...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(17)30075-5
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Smoke-free policies are important to protect health and reduce health inequalities. A major barrier to policy implementation in psychiatric hospitals is staff concern that physical violence will increase. We aimed to assess the effect of implementing a comprehensive smoke-free policy on rates of physical ass...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(17)30209-2
更新日期：2017-07-01 00:00:00
abstract：:High-quality data on funding for mental health research are essential to mapping funding levels, identifying gaps in the funding landscape, and tracking the impact of research funding. To date, quantitative analyses of research funding in mental health have been restricted in scope. In this Health Policy paper, we pre...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(20)30469-7
更新日期：2020-11-23 00:00:00
abstract：:Suicide is the 15th leading cause of death worldwide, with over 75% of suicides occurring in low-income and middle-income countries. Nonetheless, evidence on the association between suicide and poverty in low-income and middle-income countries is scarce. We did a systematic review to understand the association between...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(16)30066-9
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:With a lifetime risk for major depressive disorder of up to 50%, depression is a common comorbidity in multiple sclerosis but remains widely underdiagnosed and untreated. We investigated the potential of a fully automated, internet-based, cognitive behavioural therapy programme, Deprexis, to reduce depressiv...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/S2215-0366(14)00049-2
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Acting on command hallucinations in psychosis can have serious consequences for the individual and for other people and is a major cause of clinical and public concern. No evidence-based treatments are available to reduce this risk behaviour. We therefore tested our new cognitive therapy to challenge the per...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(14)70247-0
更新日期：2014-06-01 00:00:00
abstract：:We argue that the global burden of mental illness is underestimated and examine the reasons for under-estimation to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskele...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(15)00505-2
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:There is major concern about the impact of the global COVID-19 outbreak on mental health. Several studies suggest that mental health deteriorated in many countries before and during enforced isolation (ie, lockdown), but it remains unknown how mental health has changed week by week over the course of the COV...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(20)30482-X
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the compl...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(16)00097-3
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Self-harm in adolescents is common and repetition occurs in a high proportion of these cases. Scarce evidence exists for effectiveness of interventions to reduce self-harm. METHODS:This pragmatic, multicentre, randomised, controlled trial of family therapy versus treatment as usual was done at 40 UK Child a...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/S2215-0366(18)30058-0
更新日期：2018-03-01 00:00:00
abstract：:Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients. This Personal...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(19)30293-7
更新日期：2020-02-01 00:00:00
abstract：:A spectrum of severity of paranoia (unfounded thoughts that others are deliberately intending to cause harm) exists within the general population. This is unsurprising: deciding whether to trust or mistrust is a vital aspect of human cognition, but accurate judgment of others' intentions is challenging. The severest f...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(16)00066-3
更新日期：2016-07-01 00:00:00
abstract：:The care of people with first-episode mania has been overlooked in comparison with the care of patients with other non-affective psychoses, despite evidence suggesting targeted treatments might be of benefit for this patient group. In this Personal View, we outline the general epidemiology of first-episode mania in th...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(19)30082-3
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:In view of the high co-occurrence of depression and insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia intervention. We aimed to assess whether an online self-help insomnia program could reduce depression symptoms. METHODS:We did this randomised controlled trial ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/S2215-0366(15)00536-2
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(18)30137-8
更新日期：2018-06-01 00:00:00
abstract：:Substance use in young people (aged 10-24 years) might disrupt key periods of transition that occur as the adolescent brain undergoes cognitive and emotional development, and key psychosocial transitions are made. Adolescence is the peak time for initiation of substance use, with tobacco and alcohol usually preceding ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(15)00508-8
更新日期：2016-03-01 00:00:00
abstract：:Mental health has been included in the UN Sustainable Development Goals. However, uncertainty exists about the extent to which the major social determinants of mental disorders are addressed by these goals. The aim of this study was to develop a conceptual framework for the social determinants of mental disorders that...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章
doi：10.1016/S2215-0366(18)30060-9
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS:In a ...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1016/S2215-0366(17)30233-X
更新日期：2017-08-01 00:00:00
abstract：:Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cau...
journal_title：The lancet. Psychiatry
pub_type： 杂志文章,评审
doi：10.1016/S2215-0366(16)30266-8
更新日期：2016-12-01 00:00:00
