Persecutory delusions: a cognitive perspective on understanding and treatment.

abstract：:The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover,...

journal_title：The lancet. Psychiatry

authors： Luza S,Opazo CM,Bousman CA,Pantelis C,Bush AI,Everall IP

更新日期：2020-06-01 00:00:00

abstract：:Suicide is the 15th leading cause of death worldwide, with over 75% of suicides occurring in low-income and middle-income countries. Nonetheless, evidence on the association between suicide and poverty in low-income and middle-income countries is scarce. We did a systematic review to understand the association between...

journal_title：The lancet. Psychiatry

authors： Iemmi V,Bantjes J,Coast E,Channer K,Leone T,McDaid D,Palfreyman A,Stephens B,Lund C

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30-40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to determine whether cognitive behavioural therapy (CBT) is an effective t...

journal_title：The lancet. Psychiatry

authors： Morrison AP,Pyle M,Gumley A,Schwannauer M,Turkington D,MacLennan G,Norrie J,Hudson J,Bowe SE,French P,Byrne R,Syrett S,Dudley R,McLeod HJ,Griffiths H,Barnes TRE,Davies L,Kingdon D,FOCUS trial group.

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Social anxiety disorder-a chronic and naturally unremitting disease that causes substantial impairment-can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety di...

journal_title：The lancet. Psychiatry

authors： Mayo-Wilson E,Dias S,Mavranezouli I,Kew K,Clark DM,Ades AE,Pilling S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The conceptualisation of transgender identity as a mental disorder has contributed to precarious legal status, human rights violations, and barriers to appropriate health care among transgender people. The proposed reconceptualisation of categories related to transgender identity in WHO's forthcoming Interna...

journal_title：The lancet. Psychiatry

authors： Robles R,Fresán A,Vega-Ramírez H,Cruz-Islas J,Rodríguez-Pérez V,Domínguez-Martínez T,Reed GM

更新日期：2016-09-01 00:00:00

abstract：:Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics res...

journal_title：The lancet. Psychiatry

authors： Stephan KE,Bach DR,Fletcher PC,Flint J,Frank MJ,Friston KJ,Heinz A,Huys QJM,Owen MJ,Binder EB,Dayan P,Johnstone EC,Meyer-Lindenberg A,Montague PR,Schnyder U,Wang XJ,Breakspear M

更新日期：2016-01-01 00:00:00

abstract：:We argue that the global burden of mental illness is underestimated and examine the reasons for under-estimation to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskele...

journal_title：The lancet. Psychiatry

authors： Vigo D,Thornicroft G,Atun R

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Depressive symptoms are a major cause of disability in bipolar disorder and there are few safe and effective treatments. The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. We aimed to determine if combination therapy with quetiapine plus la...

journal_title：The lancet. Psychiatry

authors： Geddes JR,Gardiner A,Rendell J,Voysey M,Tunbridge E,Hinds C,Yu LM,Hainsworth J,Attenburrow MJ,Simon J,Goodwin GM,Harrison PJ,CEQUEL Investigators and Collaborators.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems with social functioning. We aimed to assess the efficacy of early intervention services augmented with social r...

journal_title：The lancet. Psychiatry

authors： Fowler D,Hodgekins J,French P,Marshall M,Freemantle N,McCrone P,Everard L,Lavis A,Jones PB,Amos T,Singh S,Sharma V,Birchwood M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population; however, no meta-analysis has provided prevalence data within and between syndromes. In this systematic review and meta-analysis, we aimed to synthesise data f...

journal_title：The lancet. Psychiatry

authors： Richards C,Jones C,Groves L,Moss J,Oliver C

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Housing First is increasingly implemented for homeless adults with mental illness in large urban centres, but little is known about its long-term effectiveness. The At Home/Chez Soi randomised controlled trial done in five cities in Canada showed that Housing First improved housing stability and other select...

journal_title：The lancet. Psychiatry

authors： Stergiopoulos V,Mejia-Lancheros C,Nisenbaum R,Wang R,Lachaud J,O'Campo P,Hwang SW

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort ...

journal_title：The lancet. Psychiatry

authors： Harvey SB,Sellahewa DA,Wang MJ,Milligan-Saville J,Bryan BT,Henderson M,Hatch SL,Mykletun A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures. METHODS:Using Swedish national registers, we linked data on dispensed statin prescriptions with data o...

journal_title：The lancet. Psychiatry

authors： Molero Y,Cipriani A,Larsson H,Lichtenstein P,D'Onofrio BM,Fazel S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:In view of the high co-occurrence of depression and insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia intervention. We aimed to assess whether an online self-help insomnia program could reduce depression symptoms. METHODS:We did this randomised controlled trial ...

journal_title：The lancet. Psychiatry

authors： Christensen H,Batterham PJ,Gosling JA,Ritterband LM,Griffiths KM,Thorndike FP,Glozier N,O'Dea B,Hickie IB,Mackinnon AJ

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of self-harm, and variations in area-level socioeconomic deprivation, and estimated the incidence of sui...

journal_title：The lancet. Psychiatry

authors： Geulayov G,Casey D,Bale L,Brand F,Clements C,Farooq B,Kapur N,Ness J,Waters K,Tsiachristas A,Hawton K

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:In high-income countries, maternal postnatal depression is associated with adverse outcomes in the child. However, few studies have investigated this relation in countries of low and middle income. Furthermore, to our knowledge, no studies have followed up cohorts into later childhood. We aimed to investigat...

journal_title：The lancet. Psychiatry

authors： Verkuijl NE,Richter L,Norris SA,Stein A,Avan B,Ramchandani PG

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Several small studies suggest that the adjunctive use of anti-inflammatory agents might improve depressive symptoms in bipolar disorder. However, there are few well designed, appropriately powered clinical trials assessing the efficacy of these novel treatment strategies. We aimed to assess the efficacy of a...

journal_title：The lancet. Psychiatry

authors： Husain MI,Chaudhry IB,Khoso AB,Husain MO,Hodsoll J,Ansari MA,Naqvi HA,Minhas FA,Carvalho AF,Meyer JH,Deakin B,Mulsant BH,Husain N,Young AH

更新日期：2020-06-01 00:00:00

abstract：:South Africa witnessed a national tragedy between October, 2015, and June, 2016, when the Department of Health in Gauteng province moved 1711 mental health-care users with severe mental illness or severe and profound intellectual disability out of facilities managed by a private company, Life Esidimeni, mainly into th...

journal_title：The lancet. Psychiatry

authors： Freeman MC

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The PACE trial found that, when added to specialist medical care (SMC), cognitive behavioural therapy (CBT), or graded exercise therapy (GET) were superior to adaptive pacing therapy (APT) or SMC alone in improving fatigue and physical functioning in people with chronic fatigue syndrome 1 year after randomis...

journal_title：The lancet. Psychiatry

authors： Sharpe M,Goldsmith KA,Johnson AL,Chalder T,Walker J,White PD

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. METHODS:We did an international online survey in French, German,...

journal_title：The lancet. Psychiatry

authors： Chevance A,Ravaud P,Tomlinson A,Le Berre C,Teufer B,Touboul S,Fried EI,Gartlehner G,Cipriani A,Tran VT

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) added to specialist medical care (SMC), or graded exercise therapy (GET) added to SMC, are more effective in reducing fatigue and improving physical function than both adaptive pacing therapy (APT) plus SMC and SMC alone for chronic fatigue syndrome. We investigate putative ...

journal_title：The lancet. Psychiatry

authors： Chalder T,Goldsmith KA,White PD,Sharpe M,Pickles AR

更新日期：2015-02-01 00:00:00

abstract：:Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of ...

journal_title：The lancet. Psychiatry

authors： Lai MC,Baron-Cohen S

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Compulsory community treatment (CCT) aims to reduce hospital readmissions among people with mental illness. However, research examining the usefulness of CCT is inconclusive. We aimed to assess the effectiveness of CCT in reducing readmission and length of stay in hospital and increasing community service us...

journal_title：The lancet. Psychiatry

authors： Barnett P,Matthews H,Lloyd-Evans B,Mackay E,Pilling S,Johnson S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Adults with intellectual disabilities have substantial health inequalities and poor access to health care. We assessed whether practice nurse-delivered health checks could improve the health of adults with intellectual disabilities compared with standard care. METHODS:In this cluster-design, single-blind, r...

journal_title：The lancet. Psychiatry

authors： Cooper SA,Morrison J,Allan LM,McConnachie A,Greenlaw N,Melville CA,Baltzer MC,McArthur LA,Lammie C,Martin G,Grieve EA,Fenwick E

更新日期：2014-12-01 00:00:00

abstract：:Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach. First, we discuss what...

journal_title：The lancet. Psychiatry

authors： Thapar A,Cooper M,Rutter M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Exercise is known to be associated with reduced risk of all-cause mortality, cardiovascular disease, stroke, and diabetes, but its association with mental health remains unclear. We aimed to examine the association between exercise and mental health burden in a large sample, and to better understand the infl...

journal_title：The lancet. Psychiatry

authors： Chekroud SR,Gueorguieva R,Zheutlin AB,Paulus M,Krumholz HM,Krystal JH,Chekroud AM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Many older adults with major depression, particularly veterans, do not have access to evidence-based psychotherapy. Telemedicine could increase access to best-practice care for older adults facing barriers of mobility, stigma, and geographical isolation. We aimed to establish non-inferiority of behavioural a...

journal_title：The lancet. Psychiatry

authors： Egede LE,Acierno R,Knapp RG,Lejuez C,Hernandez-Tejada M,Payne EH,Frueh BC

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Anxiety in children is common, impairs everyday functioning, and increases the risk of severe mental health disorders in adulthood. We investigated the effect of a classroom-based cognitive behaviour therapy prevention programme (FRIENDS) on anxiety symptoms in children. METHODS:Preventing Anxiety in Childr...

journal_title：The lancet. Psychiatry

authors： Stallard P,Skryabina E,Taylor G,Phillips R,Daniels H,Anderson R,Simpson N

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:With a lifetime risk for major depressive disorder of up to 50%, depression is a common comorbidity in multiple sclerosis but remains widely underdiagnosed and untreated. We investigated the potential of a fully automated, internet-based, cognitive behavioural therapy programme, Deprexis, to reduce depressiv...

journal_title：The lancet. Psychiatry

authors： Fischer A,Schröder J,Vettorazzi E,Wolf OT,Pöttgen J,Lau S,Heesen C,Moritz S,Gold SM

更新日期：2015-03-01 00:00:00

abstract：:Substance use in young people (aged 10-24 years) might disrupt key periods of transition that occur as the adolescent brain undergoes cognitive and emotional development, and key psychosocial transitions are made. Adolescence is the peak time for initiation of substance use, with tobacco and alcohol usually preceding ...

journal_title：The lancet. Psychiatry

authors： Degenhardt L,Stockings E,Patton G,Hall WD,Lynskey M

更新日期：2016-03-01 00:00:00