解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0969-0
更新日期:2018-12-01 00:00:00
abstract::Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1034-8
更新日期:2018-12-01 00:00:00
abstract::Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1060-6
更新日期:2018-12-01 00:00:00
abstract::Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1049-1
更新日期:2018-12-01 00:00:00
abstract::Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1031-y
更新日期:2018-12-01 00:00:00
abstract::We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1018-8
更新日期:2018-11-01 00:00:00
abstract::The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major feature in the pathology of Parkinson's disease (PD). Using neural stem or progenitor cells (NSC/NPCs), the prospect of replacing the missing or damaged DA neurons is very attractive for PD therapy. However, little is known about the endogen...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1005-0
更新日期:2018-11-01 00:00:00
abstract::Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still u...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1012-1
更新日期:2018-11-01 00:00:00
abstract::Tenascin-C (TNC), a matricellular protein, is upregulated in brain parenchyma after experimental subarachnoid hemorrhage (SAH). Recent studies emphasize that early brain injury (EBI) should be overcome to improve post-SAH outcomes. The aim of this study was to investigate effects of TNC knockout (TNKO) on neuronal apo...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1006-z
更新日期:2018-11-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-0978-z
更新日期:2018-11-01 00:00:00
abstract::Tonic inhibition mediated by ambient levels of GABA that activate extrasynaptic GABAA receptors emerges as an essential factor that tunes neuronal network excitability in vitro and shapes behavioral responses in vivo. To address the role of neuromodulatory transmitter systems on this type of inhibition, we employed pa...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0984-1
更新日期:2018-11-01 00:00:00
abstract::Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0962-7
更新日期:2018-10-01 00:00:00
abstract::In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0900-8
更新日期:2018-10-01 00:00:00
abstract::Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0904-4
更新日期:2018-10-01 00:00:00
abstract::The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0960-9
更新日期:2018-10-01 00:00:00
abstract::The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-1095-8
更新日期:2018-10-01 00:00:00
abstract::TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-0947-6
更新日期:2018-10-01 00:00:00
abstract::Parkinson's disease (PD) is a progressive neurodegenerative disease affecting over five million individuals worldwide. The exact molecular events underlying PD pathogenesis are still not clearly known. Glia maturation factor (GMF), a neuroinflammatory protein in the brain plays an important role in the pathogenesis of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0882-6
更新日期:2018-09-01 00:00:00
abstract::Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0934-y
更新日期:2018-09-01 00:00:00
abstract::The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0857-z
更新日期:2018-08-01 00:00:00
abstract::Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0859-x
更新日期:2018-08-01 00:00:00
abstract::There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0795-9
更新日期:2018-07-01 00:00:00
abstract::Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0792-z
更新日期:2018-07-01 00:00:00
abstract::Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0759-0
更新日期:2018-07-01 00:00:00
abstract::Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be altered by self-administration of ketamine, a non-competitive antagonist of the NMDA glutamate receptor, with a...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0772-3
更新日期:2018-07-01 00:00:00
abstract::While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0832-8
更新日期:2018-07-01 00:00:00
abstract::Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-017-0778-x
更新日期:2018-07-01 00:00:00
abstract::Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0695-z
更新日期:2018-06-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-0949-4
更新日期:2018-06-01 00:00:00
abstract::Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0681-5
更新日期:2018-06-01 00:00:00
abstract::γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment o...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0705-1
更新日期:2018-06-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor subtype. Despite that metastasis of GBM beyond the central nervous system (CNS) is rare, its malignancy is attributed to the highly infiltration trait, leading to the difficulty of complete surgical excision. Matrix gla protein (MGP) is a vita...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0677-1
更新日期:2018-06-01 00:00:00
abstract::The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0697-x
更新日期:2018-06-01 00:00:00
abstract::Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-017-0692-2
更新日期:2018-06-01 00:00:00
abstract::Neurological dysfunction as a result of neuroinflammation has been reported in sepsis and cause high mortality. High levels of cytokines stimulate the formation of neurotoxic metabolites by kynurenine (KYN) pathway. Vitamin B6 (vit B6) has anti-inflammatory and antioxidant properties and also acts as a cofactor for en...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0706-0
更新日期:2018-06-01 00:00:00
abstract::In the present study, we demonstrate that molecular chaperone Hsp70 and Hsc70 is essential for normal organization and development of ommatidial cells in Drosophila melanogaster eye. An exogenously expressed dominant negative mutant of Hsp70 (K71E) and Hsc70.4 (K71S and D206S) in an eye-specific manner resulted in eye...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0650-z
更新日期:2018-05-01 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) is a novel physiological therapy that has been adopted to clinically treat psychiatric disorders. Our previous study indicated the potential therapeutic effect of rTMS on posttraumatic stress disorder (PTSD). However, the exact molecular mechanism is elusive. Current...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0602-7
更新日期:2018-05-01 00:00:00
abstract::Type 2 diabetes (T2D) is a modern socioeconomic burden, mostly due to its long-term complications affecting nearly all tissues. One of them is the brain, whose dysfunctional intracellular quality control mechanisms (namely autophagy) may upregulate apoptosis, leading to cognitive dysfunction and Alzheimer disease (AD)...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0622-3
更新日期:2018-05-01 00:00:00
abstract::Cholinergic system is very important for many higher brain functions, including learning and memory. Cholinergic neurons, especially those in the basal forebrain, are specifically susceptible in some neurodegenerative diseases, such as in Alzheimer's disease (AD). Here, we studied the cholinergic system lesion effects...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0621-4
更新日期:2018-05-01 00:00:00
abstract::Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0596-1
更新日期:2018-05-01 00:00:00