The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.

abstract：:Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...

journal_title：Molecular neurobiology

authors： Mele M,Morelli S,Fazzari G,Avolio E,Alò R,Piscioneri A,De Bartolo L,Facciolo RM,Canonaco M

更新日期：2017-11-01 00:00:00

abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

journal_title：Molecular neurobiology

authors： Sun F,Johnson SR,Jin K,Uteshev VV

更新日期：2017-04-01 00:00:00

abstract：:Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...

journal_title：Molecular neurobiology

authors： Neves LMS,Gonçalves ECD,Cavalli J,Vieira G,Laurindo LR,Simões RR,Coelho IS,Santos ARS,Marcolino AM,Cola M,Dutra RC

更新日期：2018-07-01 00:00:00

abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...

journal_title：Molecular neurobiology

authors： Ulusoy A,Di Monte DA

更新日期：2013-04-01 00:00:00

abstract：:We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...

journal_title：Molecular neurobiology

authors： Lopez JR,Uryash A,Kolster J,Estève E,Zhang R,Adams JA

更新日期：2018-11-01 00:00:00

abstract：:Intracerebroventricular (icv) amyloid-beta (Aβ)1-40 infusion to mice has been demonstrated to cause neurotoxicty and depressive-like behavior and it can be used to evaluate antidepressant and neuroprotective effect of drugs. Atorvastatin is a widely used statin that has demonstrated antidepressant-like effect in predi...

journal_title：Molecular neurobiology

authors： Ludka FK,Cunha MP,Dal-Cim T,Binder LB,Constantino LC,Massari CM,Martins WC,Rodrigues ALS,Tasca CI

更新日期：2017-10-01 00:00:00

abstract：:The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...

journal_title：Molecular neurobiology

authors： Moutinho M,Nunes MJ,Gomes AQ,Gama MJ,Cedazo-Minguez A,Rodrigues CM,Björkhem I,Rodrigues E

更新日期：2015-01-01 00:00:00

abstract：:There is robust evidence that major depression (MDD) is accompanied by a low-grade activation of the immune-inflammatory response system, which is involved in the pathophysiology of this disorder. It is also becoming apparent that glia cells are in reciprocal communication with neurons, orchestrate various neuromodula...

journal_title：Molecular neurobiology

authors： Rudzki L,Maes M

更新日期：2020-10-01 00:00:00

abstract：:Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribute to the pathogenesis of Parkinson's disease (PD) and several other n...

journal_title：Molecular neurobiology

authors： Silva BA,Breydo L,Fink AL,Uversky VN

更新日期：2013-04-01 00:00:00

abstract：:Neurons are able to adjust the sensitivity of receptor-mediated processes according to the level of receptor activation. Extrapolating from our knowledge of other cellular proteins, regulation of receptor mRNA availability would provide a highly economical means of achieving this objective. Epidermal growth factor is ...

journal_title：Molecular neurobiology

authors： Morris BJ

更新日期：1993-10-01 00:00:00

abstract：:HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we investigated how ox...

journal_title：Molecular neurobiology

authors： Sivalingam K,Cirino TJ,McLaughlin JP,Samikkannu T

更新日期：2021-02-01 00:00:00

abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...

journal_title：Molecular neurobiology

authors： Zhang J,Shipston MJ,Brown SB

更新日期：2010-08-01 00:00:00

abstract：:B-50 (GAP-43) is an axonal, plasma membrane-associated protein involved in growth cone morphology and function. We have conducted immunocytochemical, electron microscopic, and time-lapse experiments to visualize morphological consequences of local accumulations of B-50 at the plasma membrane of B-50-transfected PC-B2 ...

journal_title：Molecular neurobiology

authors： Aarts LH,Verkade P,Schrama LH,Oestreicher AB,Gispen WH,Schotman P

更新日期：1999-08-01 00:00:00

abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...

journal_title：Molecular neurobiology

authors： Cairns BE,O'Brien M,Dong XD,Gazerani P

更新日期：2017-07-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Mül...

journal_title：Molecular neurobiology

authors： Wilkerson JL,Stiles MA,Gurley JM,Grambergs RC,Gu X,Elliott MH,Proia RL,Mandal NA

更新日期：2019-10-01 00:00:00

abstract：:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...

journal_title：Molecular neurobiology

authors： Abdullah AI,Pollock A,Sun T

更新日期：2012-06-01 00:00:00

abstract：:Metals perform important functions in the normal physiological system, and alterations in their levels may lead to a number of diseases. Aluminium (Al) has been implicated as a major risk factor, which is linked to several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. On the other h...

journal_title：Molecular neurobiology

authors： Singla N,Dhawan DK

更新日期：2014-10-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...

journal_title：Molecular neurobiology

authors： Zieger E,Candiani S,Garbarino G,Croce JC,Schubert M

更新日期：2018-06-01 00:00:00

abstract：:Although the use, and misuse, of methylphenidate is increasing in childhood and adolescence, there is little information about the consequences of this psychostimulant chronic use on brain and behavior during development. The aim of the present study was to investigate hippocampus biochemical, histochemical, and behav...

journal_title：Molecular neurobiology

authors： Schmitz F,Pierozan P,Rodrigues AF,Biasibetti H,Grunevald M,Pettenuzzo LF,Scaini G,Streck EL,Netto CA,Wyse ATS

更新日期：2017-08-01 00:00:00

abstract：:Due to the prevalence of neuromuscular disorders such as amyotrophic lateral sclerosis and spinal muscular atrophy in modern societies, defining new and efficient strategies for the treatment of these two neurodegenerative diseases has become a vital and still unfulfilled urge. Several lines of experimental evidence h...

journal_title：Molecular neurobiology

authors： Charbonnier F

更新日期：2007-06-01 00:00:00

abstract：:Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...

journal_title：Molecular neurobiology

authors： Stevens AR,Ahmed U,Vigneswara V,Ahmed Z

更新日期：2019-11-01 00:00:00

abstract：:Although in-hospital mortality rates for sepsis have decreased, survivors often experience lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long-term complications associated with sepsis. We employed a murine model to examine the influence of age and sex on the brain's response an...

journal_title：Molecular neurobiology

authors： Barter J,Kumar A,Stortz JA,Hollen M,Nacionales D,Efron PA,Moldawer LL,Foster TC

更新日期：2019-12-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors on the real-time quak...

journal_title：Molecular neurobiology

authors： Cramm M,Schmitz M,Karch A,Zafar S,Varges D,Mitrova E,Schroeder B,Raeber A,Kuhn F,Zerr I

更新日期：2015-02-01 00:00:00

abstract：:Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...

journal_title：Molecular neurobiology

authors： Dyer CA

更新日期：1993-04-01 00:00:00

abstract：:The identification of causative mutations in the (pro)granulin gene (GRN) has been a major breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated GRN mutations are leading to neurodegeneration through a "loss-of-function" mechanism, encouraging researchers to develop a growing number...

journal_title：Molecular neurobiology

authors： Kleinberger G,Capell A,Haass C,Van Broeckhoven C

更新日期：2013-02-01 00:00:00

abstract：:The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrPSc), levels of mature endogenous Sho become reduced. To study the regulatory effect of the proteostati...

journal_title：Molecular neurobiology

authors： Kang SG,Mays CE,Daude N,Yang J,Kar S,Westaway D

更新日期：2019-11-01 00:00:00

abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...

journal_title：Molecular neurobiology

authors： Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLM

更新日期：2018-10-01 00:00:00

abstract：:Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasop...

journal_title：Molecular neurobiology

authors： Richards EM,Raizada MK,Gelband CH,Sumners C

更新日期：1999-02-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...

journal_title：Molecular neurobiology

authors： Davis SM,Collier LA,Leonardo CC,Seifert HA,Ajmo CT Jr,Pennypacker KR

更新日期：2017-01-01 00:00:00