Pigment Epithelium-Derived Factor Promotes Axon Regeneration and Functional Recovery After Spinal Cord Injury.

abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...

journal_title：Molecular neurobiology

authors： Rivera DS,Lindsay CB,Codocedo JF,Carreño LE,Cabrera D,Arrese MA,Vio CP,Bozinovic F,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...

journal_title：Molecular neurobiology

authors： Corpas R,Griñán-Ferré C,Rodríguez-Farré E,Pallàs M,Sanfeliu C

更新日期：2019-02-01 00:00:00

abstract：:The administration of the anorexigenic drug d,l-fenfluramine (Ponderax) to laboratory animals results in a dose-dependent reduction in presynaptically located serotonergic reuptake transporter protein. This long-term effect may represent an altered mechanism of synthesis of the transporter (downregulation). Alternativ...

journal_title：Molecular neurobiology

authors： Westphalen RI,Dodd PR

更新日期：1995-08-01 00:00:00

abstract：:Olfactory perception and learning play a vital role in the animal's entire life for habituation and survival. Insulin and insulin receptor signaling is well known to modulate the olfactory function and is also involved in the regulation of neurogenesis. A very high density of insulin receptors is present in the olfact...

journal_title：Molecular neurobiology

authors： Mishra SK,Hidau M

更新日期：2020-10-29 00:00:00

abstract：:Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...

journal_title：Molecular neurobiology

authors： Neves LMS,Gonçalves ECD,Cavalli J,Vieira G,Laurindo LR,Simões RR,Coelho IS,Santos ARS,Marcolino AM,Cola M,Dutra RC

更新日期：2018-07-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...

journal_title：Molecular neurobiology

authors： Huang HJ,Wang YT,Lin HC,Lee YH,Lin AM

更新日期：2018-01-01 00:00:00

abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...

journal_title：Molecular neurobiology

authors： Wang W,Wang F,Liu J,Zhao W,Zhao Q,He M,Qian BJ,Xu Y,Liu R,Liu SJ,Liu W,Liu J,Zhou XF,Wang TH

更新日期：2014-10-01 00:00:00

abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...

journal_title：Molecular neurobiology

authors： Irwin JL,Yeates AJ,Mulhern MS,McSorley EM,Strain JJ,Watson GE,Grzesik K,Thurston SW,Love TM,Smith TH,Mruzek DW,Shamlaye CF,Monthy C,Myers GJ,Davidson PW,van Wijngaarden E

更新日期：2019-07-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...

journal_title：Molecular neurobiology

authors： Wu W,Guan Y,Xu K,Fu XJ,Lei XF,Lei LJ,Zhang ZQ,Cheng Y,Li YQ

更新日期：2016-05-01 00:00:00

abstract：:A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific...

journal_title：Molecular neurobiology

authors： Günther OP,Gardy JL,Stafford P,Fluge Ø,Mella O,Tang P,Miller RR,Parker SM,Johnston SA,Patrick DM

更新日期：2019-06-01 00:00:00

abstract：:In the field of the neurobiology of learning, significant emphasis has been placed on understanding neural plasticity within a single structure (or synapse type) as it relates to a particular type of learning mediated by a particular brain area. To appreciate fully the breadth of the plasticity responsible for complex...

journal_title：Molecular neurobiology

authors： Mizumori SJ,Cooper BG,Leutgeb S,Pratt WE

更新日期：2000-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. A defining hallmark of the AD brain is the presence of intraneuronal neurofibrillary tangles (NFTs) which are made up of abnormally modified tau, with aberrant phosphorylation being the most studied posttranslational modification (PTM)...

journal_title：Molecular neurobiology

authors： Guha S,Johnson GVW,Nehrke K

更新日期：2020-12-01 00:00:00

abstract：:HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we investigated how ox...

journal_title：Molecular neurobiology

authors： Sivalingam K,Cirino TJ,McLaughlin JP,Samikkannu T

更新日期：2021-02-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...

journal_title：Molecular neurobiology

authors： Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD,Yang CC,Yang CM

更新日期：2013-12-01 00:00:00

abstract：:Smarcd1 is a component of an evolutionary conserved chromatin remodeling complex-SWI/SNF, which is involved in transcription factor recruitment, DNA replication, recombination, and repair. Suppression of the SWI/SNF complex required for cellular differentiation and gene regulation may be inducible for cell proliferati...

journal_title：Molecular neurobiology

authors： Zhu Y,Wang H,Fei M,Tang T,Niu W,Zhang L

更新日期：2020-11-14 00:00:00

abstract：:Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...

journal_title：Molecular neurobiology

authors： Zhou Y,Yang T,Gong Y,Li W,Chen Y,Li J,Wang M,Yin X,Hu B,Lu Z

更新日期：2017-05-01 00:00:00

abstract：:The potassium channel tetramerization domain-containing protein 7 (KCTD7) was named after the structural homology of its predicted N-terminal broad complex, tramtrack and bric à brac/poxvirus and zinc finger domain with the T1 domain of the Kv potassium channel, but its expression profile and cellular function are sti...

journal_title：Molecular neurobiology

authors： Azizieh R,Orduz D,Van Bogaert P,Bouschet T,Rodriguez W,Schiffmann SN,Pirson I,Abramowicz MJ

更新日期：2011-08-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:TREK-1, a two-pore-domain K+ channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood. Here we examined TREK-1 contribution to neuronal morphology, e...

journal_title：Molecular neurobiology

authors： Wang W,Kiyoshi CM,Du Y,Taylor AT,Sheehan ER,Wu X,Zhou M

更新日期：2020-03-01 00:00:00

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...

journal_title：Molecular neurobiology

authors： Huang L,Lan J,Tang J,Kang Y,Feng X,Wu L,Peng Y

更新日期：2020-11-03 00:00:00

abstract：:Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD ly...

journal_title：Molecular neurobiology

authors： Wojsiat J,Laskowska-Kaszub K,Alquézar C,Białopiotrowicz E,Esteras N,Zdioruk M,Martin-Requero A,Wojda U

更新日期：2017-09-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, th...

journal_title：Molecular neurobiology

authors： Fu R,Shen Q,Xu P,Luo JJ,Tang Y

更新日期：2014-06-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:Nicotine has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unknown....

journal_title：Molecular neurobiology

authors： Liu X,Liu M,Li X,Zhang L,Fan R,Wang J

更新日期：2015-08-01 00:00:00

abstract：:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effect...

journal_title：Molecular neurobiology

authors： Li C,Zhou C,Li R

更新日期：2016-08-01 00:00:00