Abstract：
:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effects, such as cognitive impairment has been reported in both human and animal studies. While extensive evidence suggested that physical exercises can improve learning and memory activity and even prevent age-related cognitive decline, basic research revealed some common pathways between exercise and estrogen signaling that affected cognitive function. This review draws on clinical and basic studies to assess the potential impact of exercise in cognitive function from women treated with AIs for breast cancer and explore the potential mechanism and effects of exercise on estrogen-related cognition.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Li C,Zhou C,Li Rdoi
10.1007/s12035-015-9341-9subject
Has Abstractpub_date
2016-08-01 00:00:00pages
4238-4246issue
6eissn
0893-7648issn
1559-1182pii
10.1007/s12035-015-9341-9journal_volume
53pub_type
杂志文章,评审abstract：:Glycogen synthase kinase-3β (GSK-3β) is a key element to phosphorylate tau and form neurofibrillary tangles (NFTs) found in tauopathies including Alzheimer's disease (AD). A current topic for AD therapy is focused upon how to prevent tau phosphorylation. In the present study, PKCε activated Akt and inactivated GSK-3β ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9405-x
更新日期：2016-09-01 00:00:00
abstract：:Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9518-2
更新日期：2016-11-01 00:00:00
abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9301-4
更新日期：2016-08-01 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02261-1
更新日期：2021-01-08 00:00:00
abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9226-y
更新日期：2016-05-01 00:00:00
abstract：:While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0832-8
更新日期：2018-07-01 00:00:00
abstract：:Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultim...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:26:1:109
更新日期：2002-08-01 00:00:00
abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0587-2
更新日期：2018-04-01 00:00:00
abstract：:Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in human...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:22:1-3:041
更新日期：2000-08-01 00:00:00
abstract：:Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0177-8
更新日期：2017-10-01 00:00:00
abstract：:Neurons are able to adjust the sensitivity of receptor-mediated processes according to the level of receptor activation. Extrapolating from our knowledge of other cellular proteins, regulation of receptor mRNA availability would provide a highly economical means of achieving this objective. Epidermal growth factor is ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02769175
更新日期：1993-10-01 00:00:00
abstract：:Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiologic...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02123-w
更新日期：2021-01-01 00:00:00
abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0280-x
更新日期：2017-12-01 00:00:00
abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease affecting over five million individuals worldwide. The exact molecular events underlying PD pathogenesis are still not clearly known. Glia maturation factor (GMF), a neuroinflammatory protein in the brain plays an important role in the pathogenesis of...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0882-6
更新日期：2018-09-01 00:00:00
abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8683-z
更新日期：2014-10-01 00:00:00
abstract：:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02740620
更新日期：1997-02-01 00:00:00
abstract：:Parkinson's disease (PD) is a highly prevalent neurodegenerative disease for which no disease-modifying treatments are available, mainly because knowledge about its pathogenic mechanism is still incomplete. Recently, a key role for lipids emerged, but lipid profiling of brain samples from human subjects is demanding. ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01733-3
更新日期：2020-02-01 00:00:00
abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02066-2
更新日期：2020-11-01 00:00:00
abstract：:Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8374-6
更新日期：2013-04-01 00:00:00
abstract：:There is robust evidence that major depression (MDD) is accompanied by a low-grade activation of the immune-inflammatory response system, which is involved in the pathophysiology of this disorder. It is also becoming apparent that glia cells are in reciprocal communication with neurons, orchestrate various neuromodula...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-01961-y
更新日期：2020-10-01 00:00:00
abstract：:Although statins, or hydroxymethylglutaryl coenzyme A (HMG-Co A) reductase inhibitors, are generally used to decrease levels of circulating cholesterol, they have also been reported to have neuroprotective effects through various mechanisms. However, recent results have indicated that they may be harmful in patients w...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9030-0
更新日期：2016-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1211-9
更新日期：2019-04-01 00:00:00
abstract：:Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational regulation, stress granule formation, cell cycle regulation, and axonal t...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02137-4
更新日期：2021-02-01 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-0978-z
更新日期：2018-11-01 00:00:00
abstract：:Cerebellar degeneration is a devastating manifestation of cerebellar-type multiple-system atrophy (MSA), a rapidly progressive neurodegenerative disease, and the exact pathogenesis is unknown. Here, we examined the expression of micro-RNAs (miRNAs), which are short noncoding RNAs, in the cerebellum of MSA and the key ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8788-4
更新日期：2015-02-01 00:00:00
abstract：:Maternal separation (MS) causes long-lasting epigenetic changes in the brain and increases vulnerability to traumatic events in adulthood. Of interest, there may be sex-specific differences in these epigenetic changes. In this study, the extent of histone acetylation in the hippocampus (HIP) and the expression of BDNF...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02224-6
更新日期：2020-11-27 00:00:00
abstract：:A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electro...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0014-1
更新日期：2007-06-01 00:00:00
abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9903-5
更新日期：2017-07-01 00:00:00
abstract：:Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0173-z
更新日期：2017-11-01 00:00:00
abstract：:Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1625-z
更新日期：2019-11-01 00:00:00
