Abstract:
:Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultimately, epileptic condition. Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Paredes MF,Baraban SCdoi
10.1385/MN:26:1:109subject
Has Abstractpub_date
2002-08-01 00:00:00pages
109-16issue
1eissn
0893-7648issn
1559-1182pii
MN:26:1:109journal_volume
26pub_type
杂志文章,评审abstract::This article reviews a lecture I was honored to present at the Leon Wolfe Symposium in Montreal on March 25, 2004. The lecture described my research career, which started with my interaction with Wolfe at the Montreal Neurological Institute as a postdoctoral fellow and research associate and was followed by additional...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/mn:32:1:019
更新日期:2005-08-01 00:00:00
abstract::Peripheral inflammatory stimuli may activate a brain neuroinflammatory processes with consequences in brain function. The present study investigated if anthocyanins (ANT) consumption was able to prevent the memory loss, the neuronal damage, and the neuroinflammatory processes triggered by the intraperitoneal lipopolys...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9900-8
更新日期:2017-07-01 00:00:00
abstract::A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01819-y
更新日期:2020-03-01 00:00:00
abstract::This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9226-y
更新日期:2016-05-01 00:00:00
abstract::Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1614-2
更新日期:2019-11-01 00:00:00
abstract::There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-011-8183-3
更新日期:2011-08-01 00:00:00
abstract::Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, th...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-013-8620-6
更新日期:2014-06-01 00:00:00
abstract::Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9399-4
更新日期:2016-09-01 00:00:00
abstract::Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0177-8
更新日期:2017-10-01 00:00:00
abstract::The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-1095-8
更新日期:2018-10-01 00:00:00
abstract::The development of technologies for high-resolution nucleic acid localization in cells and tissues has contributed significantly to our understanding of transcriptional and translational regulation in eukaryotic cells. These methods include nonisotopic in situ hybridization methods for light and electron microscopy, a...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02741301
更新日期:1998-12-01 00:00:00
abstract::Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0450-5
更新日期:2018-02-01 00:00:00
abstract::Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1088-7
更新日期:2019-01-01 00:00:00
abstract::Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1424-y
更新日期:2019-07-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0559-6
更新日期:2018-04-01 00:00:00
abstract::Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1125-6
更新日期:2019-01-01 00:00:00
abstract::Brain GABAA/benzodiazepine receptors are highly heterogeneous. This heterogeneity is largely derived from the existence of many pentameric combinations of at least 16 different subunits that are differentially expressed in various brain regions and cell types. This molecular heterogeneity leads to binding differences ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740747
更新日期:1996-02-01 00:00:00
abstract::Regulatory mechanisms of the expression of interleukin-10 (IL-10) in brain inflammatory conditions remain elusive. To address this issue, we used multiple primary brain cell cultures to study the expression of IL-10 in lipopolysaccharide (LPS)-elicited inflammatory conditions. In neuron-glia cultures, LPS triggered we...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8889-0
更新日期:2015-08-01 00:00:00
abstract::We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1067-z
更新日期:2019-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0065-2
更新日期:2017-09-01 00:00:00
abstract::Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1273-8
更新日期:2019-04-01 00:00:00
abstract::In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8740-7
更新日期:2015-04-01 00:00:00
abstract::GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9447-0
更新日期:2016-10-01 00:00:00
abstract::Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1341-0
更新日期:2019-05-01 00:00:00
abstract::Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still u...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1012-1
更新日期:2018-11-01 00:00:00
abstract::Long-chain omega-3 polyunsaturated fatty acids (LC-O3PUFAs) exhibit therapeutic potential for the treatment and prevention of the neurological deficits associated with spinal cord injury (SCI). However, the mechanisms implicated in these protective responses remain unclear. The objective of the present functional meta...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8701-1
更新日期:2014-08-01 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1/KDM1A) plays an important role in complex cellular processes such as differentiation, proliferation, apoptosis, and cell cycle progression. It has recently been demonstrated that during development, downregulation of LSD1 inhibits cell proliferation, modulates the expression of cell...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9206-2
更新日期:2016-05-01 00:00:00
abstract::Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9518-2
更新日期:2016-11-01 00:00:00
abstract::Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740620
更新日期:1997-02-01 00:00:00
abstract::c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9522-6
更新日期:2016-11-01 00:00:00