当前位置： SCI文献检索 > MOLECULAR NEUROBIOLOGY期刊下所有文献 > Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide.

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide.

Abstract：

:Peripheral inflammatory stimuli may activate a brain neuroinflammatory processes with consequences in brain function. The present study investigated if anthocyanins (ANT) consumption was able to prevent the memory loss, the neuronal damage, and the neuroinflammatory processes triggered by the intraperitoneal lipopolysaccharide (LPS) administration. C57BL6 male mice were treated with ANT (30-100 mg/kg by gavage). With a single dose or during 10 days, before be challenged with LPS (250 μg/kg intraperitoneally single administration), a classical inductor of inflammation. The data obtained showed that ANT was able to confer protection against the memory impairment after 10 days of ANT treatment (100 mg/kg). This phytonutrient also prevented the hypothermia episode induced by LPS. Moreover, ANT prevented the increase in protein carbonyl, NOx, and MDA levels in the hippocampus and cerebral cortex (4 and 24 h) in animal challenged with LPS. ANT showed a protective effect on the increase in the pro-inflammatory cytokines content, especially Interleukin (IL)-1β, tumoral necrosis factor-α and on the reduction of IL-10 induced by LPS. ANT 100 mg/kg prevented the infiltration of peripheral immune cells in the hippocampus at 24 h post-LPS administration. In parallel, LPS increased the activity of myeloperoxidase in cortex and hippocampus, and ANT prevented this effect, also reducing microglia (Iba-1) and astrocyte (GFAP) immunoreactivity. Thus, our data support that ANT are a promising therapeutic component against brain disorders associated with process of neuroinflammation. Graphical Abstract ᅟ.

journal_name

Mol Neurobiol

journal_title

Molecular neurobiology

authors

Carvalho FB,Gutierres JM,Bueno A,Agostinho P,Zago AM,Vieira J,Frühauf P,Cechella JL,Nogueira CW,Oliveira SM,Rizzi C,Spanevello RM,Duarte MMF,Duarte T,Dellagostin OA,Andrade CM

doi

10.1007/s12035-016-9900-8

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

3350-3367

issue

5

eissn

0893-7648

issn

1559-1182

pii

10.1007/s12035-016-9900-8

journal_volume

54

pub_type

杂志文章

相关文献

MOLECULAR NEUROBIOLOGY文献大全
  • Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice.

    abstract：:Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-017-0759-0

    authors： Chen M,Puschmann TB,Marasek P,Inagaki M,Pekna M,Wilhelmsson U,Pekny M

    更新日期：2018-07-01 00:00:00

  • N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish.

    abstract：:There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigatin...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1165-y

    authors： Mocelin R,Marcon M,D'ambros S,Mattos J,Sachett A,Siebel AM,Herrmann AP,Piato A

    更新日期：2019-02-01 00:00:00

  • Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy.

    abstract：:Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the underlying disease pathogenesis. We recently reported that local drug biotransformation at the blood-brain barrier is upregulated by GR, which controls drug-metabolizing enzymes...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-020-02043-9

    authors： Hossain M,Williams S,Ferguson L,Bingaman W,Ghosh A,Najm IM,Ghosh C

    更新日期：2020-11-01 00:00:00

  • Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.

    abstract：:Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-017-0681-5

    authors： Parga JA,García-Garrote M,Martínez S,Raya Á,Labandeira-García JL,Rodríguez-Pallares J

    更新日期：2018-06-01 00:00:00

  • Conditioned Medium Derived from Neural Progenitor Cells Induces Long-term Post-ischemic Neuroprotection, Sustained Neurological Recovery, Neurogenesis, and Angiogenesis.

    abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-016-9748-y

    authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

    更新日期：2017-03-01 00:00:00

  • Legumain Knockout Protects Against Aβ1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.

    abstract：:Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving APP; however, it is unclear if legumain can poss...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-020-02219-3

    authors： Chen R,Zhang Q,Yan Y,Zhang Y,Zhang T

    更新日期：2020-11-21 00:00:00

  • A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens.

    abstract：:The transition from occasional to escalated psychostimulant use is accelerated by prior drug exposure. These behavioral observations may be related to long-lasting transcriptional and/or epigenetic changes induced by the drug pre-exposure. Herein, we investigated if a single methamphetamine (METH) injection would enha...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-019-01830-3

    authors： Jayanthi S,Torres OV,Ladenheim B,Cadet JL

    更新日期：2020-03-01 00:00:00

  • Intranasal Insulin Enhances Intracerebroventricular Streptozotocin-Induced Decrease in Olfactory Discriminative Learning via Upregulation of Subventricular Zone-Olfactory Bulb Neurogenesis in the Rat Model.

    abstract：:Olfactory perception and learning play a vital role in the animal's entire life for habituation and survival. Insulin and insulin receptor signaling is well known to modulate the olfactory function and is also involved in the regulation of neurogenesis. A very high density of insulin receptors is present in the olfact...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-020-02185-w

    authors： Mishra SK,Hidau M

    更新日期：2020-10-29 00:00:00

  • Effects of polyphenols on brain ageing and Alzheimer's disease: focus on mitochondria.

    abstract：:The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especia...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s12035-012-8282-9

    authors： Schaffer S,Asseburg H,Kuntz S,Muller WE,Eckert GP

    更新日期：2012-08-01 00:00:00

  • Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis.

    abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12035-016-9823-4

    authors： Wu S,Han Y,Hu Q,Zhang X,Cui G,Li Z,Guan Y

    更新日期：2017-05-01 00:00:00

  • Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice.

    abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-019-01849-6

    authors： Ettcheto M,Cano A,Manzine PR,Busquets O,Verdaguer E,Castro-Torres RD,García ML,Beas-Zarate C,Olloquequi J,Auladell C,Folch J,Camins A

    更新日期：2020-04-01 00:00:00

  • Paradoxical signal transduction in neurobiological systems.

    abstract：:Information processing in neurobiological systems is commonly thought to rely on the assessment of a signal-to-noise ratio as the key mechanism of signal detection; it assumes and requires that both signal and noise are concurrently available. An alternative theory holds that detection proceeds by the system appreciat...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1385/MN:24:1-3:145

    authors： Colpaert FC,Frégnac Y

    更新日期：2001-08-01 00:00:00

  • Boosting Endogenous Resistance of Brain to Ischemia.

    abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-016-9796-3

    authors： Sun F,Johnson SR,Jin K,Uteshev VV

    更新日期：2017-04-01 00:00:00

  • Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins.

    abstract：:Cannabidiol (CBD), one of the most abundant Cannabis sativa-derived compounds, has been implicated with neuroprotective effect in several human pathologies. Until now, no undesired side effects have been associated with CBD. In this study, we evaluated CBD's neuroprotective effect in terminal differentiation (mature) ...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-014-8843-1

    authors： Schönhofen P,de Medeiros LM,Bristot IJ,Lopes FM,De Bastiani MA,Kapczinski F,Crippa JA,Castro MA,Parsons RB,Klamt F

    更新日期：2015-08-01 00:00:00

  • HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.

    abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-015-9644-x

    authors： García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

    更新日期：2017-01-01 00:00:00

  • δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways.

    abstract：:We have recently demonstrated that δ-opioid receptor (DOR) activation attenuates α-synuclein expression/aggregation induced by MPP(+) and/or severe hypoxia. Since α-synuclein plays a critical role in the pathogenesis of Parkinson's disease, DOR activation may trigger an antiparkinson pathway(s) against α-synuclein-ind...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1316-1

    authors： Chen T,Wang Q,Chao D,Xia TC,Sheng S,Li ZR,Zhao JN,Wen GQ,Ding G,Xia Y

    更新日期：2019-05-01 00:00:00

  • Different Degrees of Iodine Deficiency Inhibit Differentiation of Cerebellar Granular Cells in Rat Offspring, via BMP-Smad1/5/8 Signaling.

    abstract：:Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-015-9382-0

    authors： Dong J,Lei X,Wang Y,Wang Y,Song H,Li M,Min H,Yu Y,Xi Q,Teng W,Chen J

    更新日期：2016-09-01 00:00:00

  • Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms.

    abstract：:Chronic hyperammonemia impairs spatial memory by altering membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus. Intracerebral administration of extracellular cGMP to hyperammonemic rats restores spatial memory and membrane expression of AMPA receptors. The underlying molecular mechanisms re...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1387-z

    authors： Taoro-Gonzalez L,Arenas YM,Cabrera-Pastor A,Felipo V

    更新日期：2019-06-01 00:00:00

  • Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation.

    abstract：:Retinoid X-receptors (RXRs) are members of the ligand-dependent transcription factor family of nuclear receptors that have gained recent research focus as potential targets for neurodegenerative disorders. Bexarotene is an RXR pharmacological agonist that is shown to be neuroprotective through its effects in promoting...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1041-9

    authors： Dheer Y,Chitranshi N,Gupta V,Abbasi M,Mirzaei M,You Y,Chung R,Graham SL,Gupta V

    更新日期：2018-12-01 00:00:00

  • Extracellular Vesicles of Alzheimer's Disease Patients as a Biomarker for Disease Progression.

    abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative brain pathology and the most common form of dementia. Evidence suggests that extracellular vesicles (EVs) containing cytokines and microRNA are involved in inflammation regulation. The current study aimed to explore a potential impact of AD patients' EVs on d...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-020-02013-1

    authors： Aharon A,Spector P,Ahmad RS,Horrany N,Sabbach A,Brenner B,Aharon-Peretz J

    更新日期：2020-10-01 00:00:00

  • Maternal Gestational Immune Response and Autism Spectrum Disorder Phenotypes at 7 Years of Age in the Seychelles Child Development Study.

    abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1424-y

    authors： Irwin JL,Yeates AJ,Mulhern MS,McSorley EM,Strain JJ,Watson GE,Grzesik K,Thurston SW,Love TM,Smith TH,Mruzek DW,Shamlaye CF,Monthy C,Myers GJ,Davidson PW,van Wijngaarden E

    更新日期：2019-07-01 00:00:00

  • Atorvastatin Protects from Aβ1-40-Induced Cell Damage and Depressive-Like Behavior via ProBDNF Cleavage.

    abstract：:Intracerebroventricular (icv) amyloid-beta (Aβ)1-40 infusion to mice has been demonstrated to cause neurotoxicty and depressive-like behavior and it can be used to evaluate antidepressant and neuroprotective effect of drugs. Atorvastatin is a widely used statin that has demonstrated antidepressant-like effect in predi...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-016-0134-6

    authors： Ludka FK,Cunha MP,Dal-Cim T,Binder LB,Constantino LC,Massari CM,Martins WC,Rodrigues ALS,Tasca CI

    更新日期：2017-10-01 00:00:00

  • Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT.

    abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-017-0524-4

    authors： Beker MC,Caglayan B,Yalcin E,Caglayan AB,Turkseven S,Gurel B,Kelestemur T,Sertel E,Sahin Z,Kutlu S,Kilic U,Baykal AT,Kilic E

    更新日期：2018-03-01 00:00:00

  • MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3/Caspase-1 Axis in Adult Neural Stem Cells.

    abstract：:α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-015-9620-5

    authors： Fan Z,Lu M,Qiao C,Zhou Y,Ding JH,Hu G

    更新日期：2016-12-01 00:00:00

  • Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.

    abstract：:Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the bra...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-015-9503-9

    authors： Ren M,Li K,Wang D,Guo J,Li J,Yang G,Long X,Shen W,Hu R,Wang X,Zeng K

    更新日期：2016-11-01 00:00:00

  • Emerging Trends in Retrograde Signaling.

    abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s12035-015-9280-5

    authors： Suvarna Y,Maity N,Shivamurthy MC

    更新日期：2016-05-01 00:00:00

  • Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model.

    abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-015-9203-5

    authors： Zendedel A,Johann S,Mehrabi S,Joghataei MT,Hassanzadeh G,Kipp M,Beyer C

    更新日期：2016-07-01 00:00:00

  • Activity-dependent changes in voltage-dependent calcium currents and transmitter release.

    abstract：:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02740620

    authors： Lnenicka GA,Hong SJ

    更新日期：1997-02-01 00:00:00

  • The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation.

    abstract：:The endocannabinoid system (ECS) actively participates in several physiological processes within the central nervous system. Among such, its involvement in the downregulation of the N-methyl-D-aspartate receptor (NMDAr) through a modulatory input at the cannabinoid receptors (CBr) has been established. After its produ...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章

    doi：10.1007/s12035-018-1129-2

    authors： Aguilera-Portillo G,Rangel-López E,Villeda-Hernández J,Chavarría A,Castellanos P,Elmazoglu Z,Karasu Ç,Túnez I,Pedraza G,Königsberg M,Santamaría A

    更新日期：2019-02-01 00:00:00

  • The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer's Disease-a Critical Review.

    abstract：:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...

    journal_title：Molecular neurobiology

    pub_type： 杂志文章,评审

    doi：10.1007/s12035-018-1188-4

    authors： Sochocka M,Donskow-Łysoniewska K,Diniz BS,Kurpas D,Brzozowska E,Leszek J

    更新日期：2019-03-01 00:00:00