Abstract:
:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T and ACE I/D polymorphisms and DPN found in various types of electronic databases. Strengthening the Reporting of Observational studies in Epidemiology (STROBE) quality score systems were used to determine the quality of the articles selected for inclusion. Odds ratios (ORs) and its corresponding 95 % confidence interval (95 % CI) were calculated. We used STATA statistical software (version 12.0, Stata Corporation, College Station, TX, USA) to deal with statistical data. Our results indicated an association of ACE D>I mutation (OR = 1.43, 95 % CI 1.12-1.83, P = 0.004) and MTHFR 677 C>T mutation (OR = 1.43, 95 % CI 1.08-1.90, P = 0.014) with DPN under the allele model, and similar results were also found under the dominant model (all P < 0.05). Subgroup analysis by country indicated that the MTHFR 677 C>T polymorphism may be the main risk factor for DPN in Turkey under four genetic models. ACE D>I mutation was correlated with DPN in Japanese and Pakistani populations in the majority of groups. The relationships of MTHFR 677 C>T and ACE I/D polymorphisms with DPN patients presented in this meta-analyses support the view that the MTHFR and ACE genes might play an important role in the development of DPN.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wu S,Han Y,Hu Q,Zhang X,Cui G,Li Z,Guan Ydoi
10.1007/s12035-016-9823-4subject
Has Abstractpub_date
2017-05-01 00:00:00pages
2435-2444issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9823-4journal_volume
54pub_type
杂志文章,meta分析abstract::Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01722-6
更新日期:2020-01-01 00:00:00
abstract::Beginning in the early stages of Alzheimer's disease (AD), the hippocampus reduces its functional connections to other cortical regions due to synaptic depletion. However, little is known regarding connectivity abnormalities within the hippocampus. Here, we describe rostral-caudal hippocampal convergence (rcHC), a met...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01671-0
更新日期:2019-12-01 00:00:00
abstract::Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiologic...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02123-w
更新日期:2021-01-01 00:00:00
abstract::Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0524-4
更新日期:2018-03-01 00:00:00
abstract::Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0934-y
更新日期:2018-09-01 00:00:00
abstract::Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1302-7
更新日期:2019-05-01 00:00:00
abstract::Although statins, or hydroxymethylglutaryl coenzyme A (HMG-Co A) reductase inhibitors, are generally used to decrease levels of circulating cholesterol, they have also been reported to have neuroprotective effects through various mechanisms. However, recent results have indicated that they may be harmful in patients w...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9030-0
更新日期:2016-01-01 00:00:00
abstract::Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8277-6
更新日期:2012-06-01 00:00:00
abstract::Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1125-6
更新日期:2019-01-01 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment and whether growth factors and neurogenesis played a role in t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9013-1
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8355-9
更新日期:2013-02-01 00:00:00
abstract::Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8847-x
更新日期:2015-08-01 00:00:00
abstract::One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1188-4
更新日期:2019-03-01 00:00:00
abstract::Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1506-5
更新日期:2019-09-01 00:00:00
abstract::Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0280-x
更新日期:2017-12-01 00:00:00
abstract::Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8383-5
更新日期:2013-06-01 00:00:00
abstract::A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9541-3
更新日期:2016-11-01 00:00:00
abstract::Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-015-9280-5
更新日期:2016-05-01 00:00:00
abstract::Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01701-x
更新日期:2020-01-01 00:00:00
abstract::Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly under...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0080-3
更新日期:2017-09-01 00:00:00
abstract::There is robust evidence that major depression (MDD) is accompanied by a low-grade activation of the immune-inflammatory response system, which is involved in the pathophysiology of this disorder. It is also becoming apparent that glia cells are in reciprocal communication with neurons, orchestrate various neuromodula...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-020-01961-y
更新日期:2020-10-01 00:00:00
abstract::The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9471-0
更新日期:2016-10-01 00:00:00
abstract::Involvement of membrane mineralocorticoid (MC) and glucocorticoid (GC) receptors in synaptic Zn2+ dynamics remains unclear. Here, we tested whether synaptic plasticity is affected by rapid intracellular Zn2+ dysregulation via membrane MC and GC receptor activation, in comparison with intracellular Ca2+ dysregulation. ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1159-9
更新日期:2019-02-01 00:00:00
abstract::Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9968-1
更新日期:2017-08-01 00:00:00
abstract::After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme protein, is involved in cytoprotection. To date, neuroglobin levels have been positively correlated with a beneficial outcome in a plethora of neurotoxic insults, e.g., ischemic and traumatic brain injuries and Alzheimer's disease....
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1212-8
更新日期:2019-03-01 00:00:00
abstract::Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9246-7
更新日期:2015-10-01 00:00:00
abstract::Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has bee...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:27:1:13
更新日期:2003-02-01 00:00:00
abstract::Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0057-2
更新日期:2017-01-01 00:00:00
abstract::The question of how the cell surface molecules may be specifically delivered to subdomains of neurons is of particular interest considering that polarized sorting to the axon could enable adhesion glycoproteins to induce fasciculation of axonal tracts, guidance to the target cell, and the establishment of synaptic con...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02780608
更新日期:1993-04-01 00:00:00
abstract::This study examined the effects of pinealectomy in Wistar rats and melatonin replacement therapy on the daily mRNA expression of melatonin (Tph1, Aanat, Asmt, Mt1, Mt2, and Rorα), and steroidogenic (Star, 17βhsd3, and Lhr) related genes as well as clock genes (Rev-erbα, Bmal1, Per1, Per2, Cry1, and Cry2) in testes. Th...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1626-y
更新日期:2019-11-01 00:00:00