Paradoxical signal transduction in neurobiological systems.

abstract：:Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...

journal_title：Molecular neurobiology

authors： Wang X,Wang ZH,Wu YY,Tang H,Tan L,Wang X,Gao XY,Xiong YS,Liu D,Wang JZ,Zhu LQ

更新日期：2013-02-01 00:00:00

abstract：:Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiesce...

journal_title：Molecular neurobiology

authors： Grison A,Atanasoski S

更新日期：2020-07-01 00:00:00

abstract：:Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively serve to regulate normal ...

journal_title：Molecular neurobiology

authors： Mazzone SB,Tian L,Moe AAK,Trewella MW,Ritchie ME,McGovern AE

更新日期：2020-02-01 00:00:00

abstract：:Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokine...

journal_title：Molecular neurobiology

authors： Ogata T,Yamamoto S,Nakamura K,Tanaka S

更新日期：2006-02-01 00:00:00

abstract：:Specific variations in the amino acid sequence of prion protein (PrP) are key determinants of susceptibility to prion diseases. We previously showed that an amino acid substitution specific to canids confers resistance to prion diseases when expressed in mice and demonstrated its dominant-negative protective effect ag...

journal_title：Molecular neurobiology

authors： Otero A,Hedman C,Fernández-Borges N,Eraña H,Marín B,Monzón M,Sánchez-Martín MA,Nonno R,Badiola JJ,Bolea R,Castilla J

更新日期：2019-09-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

journal_title：Molecular neurobiology

authors： Sun F,Johnson SR,Jin K,Uteshev VV

更新日期：2017-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. A defining hallmark of the AD brain is the presence of intraneuronal neurofibrillary tangles (NFTs) which are made up of abnormally modified tau, with aberrant phosphorylation being the most studied posttranslational modification (PTM)...

journal_title：Molecular neurobiology

authors： Guha S,Johnson GVW,Nehrke K

更新日期：2020-12-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease characterized by degeneration of upper and lower motor neurons (MNs), generalized weakness and muscle atrophy. The "neurocentric" view of ALS assumes that the disease primarily affects motor neurons, while muscle alterations only...

journal_title：Molecular neurobiology

authors： Pansarasa O,Rossi D,Berardinelli A,Cereda C

更新日期：2014-04-01 00:00:00

abstract：:Classical galactosemia is an inborn error of carbohydrate metabolism in which patients accumulate high concentration of galactose in the brain. The most common treatment is a galactose-restricted diet. However, even treated patients develop several complications. One of the most common symptoms is motor coordination i...

journal_title：Molecular neurobiology

authors： Rodrigues AF,Biasibetti H,Zanotto BS,Sanches EF,Schmitz F,Nunes VT,Pierozan P,Manfredini V,Magro DDD,Netto CA,Wyse ATS

更新日期：2017-08-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...

journal_title：Molecular neurobiology

authors： Gasparini S,Del Vecchio G,Gioiosa S,Flati T,Castrignano T,Legnini I,Licursi V,Ricceri L,Scattoni ML,Rinaldi A,Presutti C,Mannironi C

更新日期：2020-05-01 00:00:00

abstract：:The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild st...

journal_title：Molecular neurobiology

authors： Shang X,Shang Y,Fu J,Zhang T

更新日期：2017-08-01 00:00:00

abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...

journal_title：Molecular neurobiology

authors： O'Dowd DK,Smith MA

更新日期：1996-12-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...

journal_title：Molecular neurobiology

authors： Pasqualetti F,Orlandi P,Simeon V,Cantarella M,Giuliani D,Di Desidero T,Gonnelli A,Delishaj D,Lombardi G,Sechi A,Sanson M,Zagonel V,Paiar F,Danesi R,Guarini S,Bocci G

更新日期：2018-02-01 00:00:00

abstract：:Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a variety of pain state. However, the underlying mechanisms of SDF1-CXCR4 signaling leading to the maintenance of chronic pain states are poorly understood. In the present study, we sough...

journal_title：Molecular neurobiology

authors： Yang F,Sun W,Luo WJ,Yang Y,Yang F,Wang XL,Chen J

更新日期：2017-05-01 00:00:00

abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...

journal_title：Molecular neurobiology

authors： Malenka RC

更新日期：1991-01-01 00:00:00

abstract：:Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression of neurological disorders such as Alzheimer's disease and dementia. The administration of this drug in humans presents several criticisms due to its short half-life, poor stability, and high doses needed to achieve the effect. Th...

journal_title：Molecular neurobiology

authors： Ruozi B,Belletti D,Sharma HS,Sharma A,Muresanu DF,Mössler H,Forni F,Vandelli MA,Tosi G

更新日期：2015-10-01 00:00:00

abstract：:Morphine as an opioid is an important drug in the treatment of moderate to severe pain. Several stress factors via generation of nitric oxide (NO) and oxidative stress (OS) are responsible for the adverse effects of morphine-induced analgesia, addiction, and antinociceptive tolerance, including altered Ca2+ concentrat...

journal_title：Molecular neurobiology

authors： Osmanlıoğlu HÖ,Yıldırım MK,Akyuva Y,Yıldızhan K,Nazıroğlu M

更新日期：2020-08-01 00:00:00

abstract：:Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological mechanisms in Huntington's disease (HD), a neurodegenerative disease...

journal_title：Molecular neurobiology

authors： Naia L,Rosenstock TR,Oliveira AM,Oliveira-Sousa SI,Caldeira GL,Carmo C,Laço MN,Hayden MR,Oliveira CR,Rego AC

更新日期：2017-09-01 00:00:00

abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...

journal_title：Molecular neurobiology

authors： Zhang JC,Xu H,Yuan Y,Chen JY,Zhang YJ,Lin Y,Yuan SY

更新日期：2017-07-01 00:00:00

abstract：:Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribute to the pathogenesis of Parkinson's disease (PD) and several other n...

journal_title：Molecular neurobiology

authors： Silva BA,Breydo L,Fink AL,Uversky VN

更新日期：2013-04-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...

journal_title：Molecular neurobiology

authors： Boutin H,Kimber I,Rothwell NJ,Pinteaux E

更新日期：2003-06-01 00:00:00

abstract：:Neuronal plasticity can be defined as adaptive changes in structure and function of the nervous system, an obvious example of which is the capacity to remember and learn. Long-term potentiation and long-term depression are the experimental models of memory in the central nervous system (CNS), and have been frequently ...

journal_title：Molecular neurobiology

authors： Tokuda M,Hatase O

更新日期：1998-01-01 00:00:00

abstract：:The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...

journal_title：Molecular neurobiology

authors： Rzemieniec J,Litwa E,Wnuk A,Lason W,Krzeptowski W,Kajta M

更新日期：2016-10-01 00:00:00

abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...

journal_title：Molecular neurobiology

authors： Vohra R,Kolko M

更新日期：2020-04-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mi...

journal_title：Molecular neurobiology

authors： Waugh MG

更新日期：2016-01-01 00:00:00

abstract：:Parkinson's disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered an intrinsically disordered 14 kDa monomer, and although poorly understood, its transition to higher-order multimeric species...

journal_title：Molecular neurobiology

authors： Abdullah R,Patil KS,Rosen B,Pal R,Prabhudesai S,Lee S,Basak I,Hoedt E,Yang P,Panick K,Ho HP,Chang E,Tzoulis C,Larsen JP,Neubert TA,Alves G,Møller SG

更新日期：2017-12-01 00:00:00