Abstract:
:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In particular, Ca2+ channels play a prominent role in depolarization-secretion coupling, where the release of neurotransmitter is very sensitive to changes in voltage-dependent Ca2+ currents. An important feature of Ca2+ channels is their regulation by electrical activity. Depolarization can selectively modulate the properties of Ca2+ channel types, thus shaping the response of the neuron to future electrical activity. In this article, we examine the diversity of Ca2+ channels found in vertebrate and invertebrate neurons, and their short- and long-term regulation by membrane potential and Ca2+ influx. Additionally, we consider the extent to which this activity-dependent regulation of Ca2+ currents contributes to the development and plasticity of transmitter releasing properties. In the studies of long-term regulation, we focus on crustacean motoneurons where activity levels, Ca2+ channel properties, and transmitter releasing properties can be followed in identified neurons.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Lnenicka GA,Hong SJdoi
10.1007/BF02740620subject
Has Abstractpub_date
1997-02-01 00:00:00pages
37-66issue
1-2eissn
0893-7648issn
1559-1182journal_volume
14pub_type
杂志文章,评审abstract::The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02936609
更新日期:1987-10-01 00:00:00
abstract::Inflammation plays a crucial role in the pathogenesis of stroke. This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0346-9
更新日期:2018-01-01 00:00:00
abstract::Galectin-1 (Gal-1) shows neuroprotective activity in brain ischemia, spinal cord injury, and autoimmune neuroinflammation. To evaluate the Gal-1 situation in the brains of prion disease, the brain levels of Gal-1 in several scrapie-infected experimental rodent models were tested by Western blot, including agents 263K-...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9923-1
更新日期:2017-07-01 00:00:00
abstract::Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1489-2
更新日期:2019-08-01 00:00:00
abstract::Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and brain pathology. This hypothesis was examined in...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9236-9
更新日期:2015-10-01 00:00:00
abstract::The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-017-0433-6
更新日期:2018-03-01 00:00:00
abstract::Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to play a critical role in the development of several malignancies. However, the potential molecular mechanism of MALAT1 in glioma remains unclear. In the present study, we found that the expression of MALAT1 wa...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02165-0
更新日期:2020-10-19 00:00:00
abstract::The human KCTD13 gene is located within the 16p11.2 locus and copy number variants of this locus are associated with a high risk for neuropsychiatric diseases including autism spectrum disorder and schizophrenia. Studies in zebrafish point to a role of KCTD13 in proliferation of neural precursor cells which may contri...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01727-1
更新日期:2020-02-01 00:00:00
abstract::Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-015-9423-8
更新日期:2016-10-01 00:00:00
abstract::Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9740-6
更新日期:2017-03-01 00:00:00
abstract::Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9000-6
更新日期:2016-01-01 00:00:00
abstract::Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8642-8
更新日期:2014-10-01 00:00:00
abstract::Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-013-8398-6
更新日期:2013-06-01 00:00:00
abstract::Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...
journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析
doi:10.1007/s12035-015-9332-x
更新日期:2016-08-01 00:00:00
abstract::Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1444-7
更新日期:2019-07-01 00:00:00
abstract::In the present study, we demonstrate that molecular chaperone Hsp70 and Hsc70 is essential for normal organization and development of ommatidial cells in Drosophila melanogaster eye. An exogenously expressed dominant negative mutant of Hsp70 (K71E) and Hsc70.4 (K71S and D206S) in an eye-specific manner resulted in eye...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0650-z
更新日期:2018-05-01 00:00:00
abstract::The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0960-9
更新日期:2018-10-01 00:00:00
abstract::The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxy...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8835-1
更新日期:2015-04-01 00:00:00
abstract::Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving APP; however, it is unclear if legumain can poss...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02219-3
更新日期:2020-11-21 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor subtype. Despite that metastasis of GBM beyond the central nervous system (CNS) is rare, its malignancy is attributed to the highly infiltration trait, leading to the difficulty of complete surgical excision. Matrix gla protein (MGP) is a vita...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0677-1
更新日期:2018-06-01 00:00:00
abstract::Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0450-5
更新日期:2018-02-01 00:00:00
abstract::Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly under...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0080-3
更新日期:2017-09-01 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析
doi:10.1007/s12035-016-9823-4
更新日期:2017-05-01 00:00:00
abstract::The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the development...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-9715-7
更新日期:2017-03-01 00:00:00
abstract::Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8365-7
更新日期:2013-04-01 00:00:00
abstract::Cannabidiol (CBD), one of the most abundant Cannabis sativa-derived compounds, has been implicated with neuroprotective effect in several human pathologies. Until now, no undesired side effects have been associated with CBD. In this study, we evaluated CBD's neuroprotective effect in terminal differentiation (mature) ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8843-1
更新日期:2015-08-01 00:00:00
abstract::AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulato...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8704-y
更新日期:2014-12-01 00:00:00
abstract::CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-9787-4
更新日期:2017-04-01 00:00:00
abstract::Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02108-9
更新日期:2021-01-01 00:00:00
abstract::Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokine...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/mn:33:1:051
更新日期:2006-02-01 00:00:00