Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.

abstract：:Intracerebroventricular (icv) amyloid-beta (Aβ)1-40 infusion to mice has been demonstrated to cause neurotoxicty and depressive-like behavior and it can be used to evaluate antidepressant and neuroprotective effect of drugs. Atorvastatin is a widely used statin that has demonstrated antidepressant-like effect in predi...

journal_title：Molecular neurobiology

authors： Ludka FK,Cunha MP,Dal-Cim T,Binder LB,Constantino LC,Massari CM,Martins WC,Rodrigues ALS,Tasca CI

更新日期：2017-10-01 00:00:00

abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

journal_title：Molecular neurobiology

authors： Sun L,Tian L,Xu J,Zhang Z,Liu X

更新日期：2017-07-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a modern socioeconomic burden, mostly due to its long-term complications affecting nearly all tissues. One of them is the brain, whose dysfunctional intracellular quality control mechanisms (namely autophagy) may upregulate apoptosis, leading to cognitive dysfunction and Alzheimer disease (AD)...

journal_title：Molecular neurobiology

authors： Candeias E,Sebastião I,Cardoso S,Carvalho C,Santos MS,Oliveira CR,Moreira PI,Duarte AI

更新日期：2018-05-01 00:00:00

abstract：:The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...

journal_title：Molecular neurobiology

authors： Cigliano L,Spagnuolo MS,Crescenzo R,Cancelliere R,Iannotta L,Mazzoli A,Liverini G,Iossa S

更新日期：2018-04-01 00:00:00

abstract：:Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently, the unfolded protein response (UPR) has been shown to be involved in r...

journal_title：Molecular neurobiology

authors： Timberlake Ii M,Roy B,Dwivedi Y

更新日期：2019-12-01 00:00:00

abstract：:There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....

journal_title：Molecular neurobiology

authors： Mullin AP,Gokhale A,Larimore J,Faundez V

更新日期：2011-08-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...

journal_title：Molecular neurobiology

authors： Huang HJ,Wang YT,Lin HC,Lee YH,Lin AM

更新日期：2018-01-01 00:00:00

abstract：:Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...

journal_title：Molecular neurobiology

authors： Kim J,Ghadery C,Cho SS,Mihaescu A,Christopher L,Valli M,Houle S,Strafella AP

更新日期：2019-11-01 00:00:00

abstract：:The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input-output connections, and time of neurogenesis. Since it is thought that limbic, reward-related information and executive aspects of behavioral information may be differentially p...

journal_title：Molecular neurobiology

authors： Miura M,Masuda M,Aosaki T

更新日期：2008-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...

journal_title：Molecular neurobiology

authors： Zi Y,Yin Z,Xiao W,Liu X,Gao Z,Jiao L,Deng L

更新日期：2015-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...

journal_title：Molecular neurobiology

authors： Wang X,Wang ZH,Wu YY,Tang H,Tan L,Wang X,Gao XY,Xiong YS,Liu D,Wang JZ,Zhu LQ

更新日期：2013-02-01 00:00:00

abstract：:Previous studies have provided evidence for axon-to-myelin transfer of intact lipids and lipid precursors for reutilization by myelin enzymes. Several of the lipid constituents of myelin showed significant contralateral/ipsilateral ratios of incorporated radioactivity, indicative of axonal origin, whereas proteins and...

journal_title：Molecular neurobiology

authors： Ledeen RW,Golly F,Haley JE

更新日期：1992-07-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...

journal_title：Molecular neurobiology

authors： Rivera DS,Lindsay CB,Codocedo JF,Carreño LE,Cabrera D,Arrese MA,Vio CP,Bozinovic F,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Autism spectrum disorders (ASD) comprise a complex of neurodevelopmental disorders caused by a variety of genetic defects and characterized by alterations in social communication and repetitive behavior. Since the mechanisms leading to early neuronal degeneration remain elusive, we chose to examine the properties of N...

journal_title：Molecular neurobiology

authors： Grasselli C,Carbone A,Panelli P,Giambra V,Bossi M,Mazzoccoli G,De Filippis L

更新日期：2020-03-01 00:00:00

abstract：:Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...

journal_title：Molecular neurobiology

authors： Feng B,Liu JC,Zhang J,Ozaki K,Guo YY,Yi DH,Li XQ,Zhao MG

更新日期：2013-06-01 00:00:00

abstract：:Excess production of reactive oxygen species in the brain has been implicated as a common underlying risk factor for the pathogenesis of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In recent years, there is considerable interest concerning investig...

journal_title：Molecular neurobiology

authors： Sun AY,Wang Q,Simonyi A,Sun GY

更新日期：2010-06-01 00:00:00

abstract：:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray an...

journal_title：Molecular neurobiology

authors： Xu J,Zhang F,Gao C,Ma X,Peng X,Kong D,Hao J

更新日期：2017-04-01 00:00:00

abstract：:Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles whereas the BK channel colocalizes with voltage-sensitive Ca(2+) channels in the plasma membrane. Mounting evidence suggests that these two proteins p...

journal_title：Molecular neurobiology

authors： Wang ZW

更新日期：2008-10-01 00:00:00

abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...

journal_title：Molecular neurobiology

authors： Chen X,Chen X,Huang X,Qin C,Fang Y,Liu Y,Zhang G,Pan D,Wang W,Xie M

更新日期：2016-04-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...

journal_title：Molecular neurobiology

authors： Li J,Li H,Liu J,Feng B,Feng M,Lv B,Cheng S,Yang X

更新日期：2016-07-01 00:00:00

abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...

journal_title：Molecular neurobiology

authors： Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S

更新日期：2017-10-01 00:00:00

abstract：:Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving APP; however, it is unclear if legumain can poss...

journal_title：Molecular neurobiology

authors： Chen R,Zhang Q,Yan Y,Zhang Y,Zhang T

更新日期：2020-11-21 00:00:00

abstract：:Metals perform important functions in the normal physiological system, and alterations in their levels may lead to a number of diseases. Aluminium (Al) has been implicated as a major risk factor, which is linked to several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. On the other h...

journal_title：Molecular neurobiology

authors： Singla N,Dhawan DK

更新日期：2014-10-01 00:00:00

abstract：:Human hGDH2 arose via duplication in the apes and driven by positive selection acquired enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all mammals). To explore the biological advantage provided by the novel enzyme, we studied, by immunohistochemistry (IHC) and immunofluorescen...

journal_title：Molecular neurobiology

authors： Spanaki C,Kotzamani D,Kleopa K,Plaitakis A

更新日期：2016-10-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Olfactory dysfunction is a recognized risk factor for the pathogenesis of Alzheimer's disease (AD), while the mechanisms are still not clear. Here, we applied bilateral olfactory bulbectomy (OBX), an olfactory deprivation surgery to cause permanent anosmia, in human tau-overexpressed mice (htau mice) to investigate ch...

journal_title：Molecular neurobiology

authors： Li K,Liu FF,He CX,Huang HZ,Xie AJ,Hu F,Liu D,Wang JZ,Zhu LQ

更新日期：2016-01-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...

journal_title：Molecular neurobiology

authors： Kira J

更新日期：1994-04-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...

journal_title：Molecular neurobiology

authors： Davis SM,Collier LA,Leonardo CC,Seifert HA,Ajmo CT Jr,Pennypacker KR

更新日期：2017-01-01 00:00:00