Abstract:
:Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anxiety. However, little is known about the role of motilin in BLA neuronal circuits and the molecular mechanisms of stress-related anxiety. Whole-cell recordings from amygdala slices showed that motilin depolarized the interneurons and facilitated GABAergic transmission in the BLA, which is mimicked by the motilin receptor agonist, erythromycin. BLA local injection of erythromycin or motilin can reduce the anxiety-like behavior in mice after acute stress. Therefore, motilin is essential in regulating interneuron excitability and GABAergic transmission in BLA. Moreover, the anxiolytic actions of motilin can partly be explained by modulating the BLA neuronal circuits. The present data demonstrate the importance of motilin in anxiety and the development of motilin receptor non-peptide agonist as a clear target for the potential treatment of anxiety disorders.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Feng B,Liu JC,Zhang J,Ozaki K,Guo YY,Yi DH,Li XQ,Zhao MGdoi
10.1007/s12035-012-8383-5subject
Has Abstractpub_date
2013-06-01 00:00:00pages
892-902issue
3eissn
0893-7648issn
1559-1182journal_volume
47pub_type
杂志文章abstract::Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1263-x
更新日期:2019-04-01 00:00:00
abstract::In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0900-8
更新日期:2018-10-01 00:00:00
abstract::The neuronal circuit remodels during development as well as in human neuropathologies such as epilepsy. Neurite outgrowth is an obligatory step in these events. We recently reported that alterations in the phosphorylation state of an axon specification/guidance protein, the collapsin response mediator protein 2 (CRMP2...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9141-2
更新日期:2016-04-01 00:00:00
abstract::A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01819-y
更新日期:2020-03-01 00:00:00
abstract::The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1596-0
更新日期:2019-11-01 00:00:00
abstract::Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the bra...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9503-9
更新日期:2016-11-01 00:00:00
abstract::Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9968-1
更新日期:2017-08-01 00:00:00
abstract::It has recently been reported that the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway regulates neuronal differentiation of neural stem cells (NSCs) derived from rats or mice and is essential for the self-renewal of human embryonic stem cells (hESCs). However, the roles of ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9325-9
更新日期:2016-08-01 00:00:00
abstract::Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0240-5
更新日期:2017-11-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF), which belongs to transforming growth factor β superfamily, plays important roles in glioma pathogenesis. Gdnf mRNA is aberrantly increased in glioma cells, but the underlying transcription mechanism is unclear. Here, we found that although the base sequence in the pr...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8443-5
更新日期:2013-12-01 00:00:00
abstract::It is important to understand the molecular mechanisms of barrier disruption in the central nervous system (CNS) of patients with multiple sclerosis (MS). The purpose of the present study was to clarify whether claudin-11 is involved in the disruption of two endothelial barriers (blood-brain barrier (BBB) and blood-sp...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1207-5
更新日期:2019-03-01 00:00:00
abstract::Long-term potentiation (LTP) is a cellular model for learning and memory and believed to be critical for plastic changes in the brain. Depending on the central nervous system region, LTP has been proposed to contribute to many key physiological functions and pathological conditions, such as learning/memory, chronic pa...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-009-8085-9
更新日期:2009-12-01 00:00:00
abstract::B-50 (GAP-43) is an axonal, plasma membrane-associated protein involved in growth cone morphology and function. We have conducted immunocytochemical, electron microscopic, and time-lapse experiments to visualize morphological consequences of local accumulations of B-50 at the plasma membrane of B-50-transfected PC-B2 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02741362
更新日期:1999-08-01 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment and whether growth factors and neurogenesis played a role in t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9013-1
更新日期:2016-01-01 00:00:00
abstract::Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are el...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0485-7
更新日期:2018-03-01 00:00:00
abstract::Astroglial scaring and limited neurogenesis are two problematic issues in recovery of spinal cord injury (SCI). In the meantime, it seems that mechanical manipulations of scaffold to inhibit astroglial scarring and improve neurogenesis is worthy of value. In the present investigation, the effect of nanofiber (gel) con...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9836-z
更新日期:2017-05-01 00:00:00
abstract::Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9246-7
更新日期:2015-10-01 00:00:00
abstract::Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal-lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderato...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9827-0
更新日期:2017-05-01 00:00:00
abstract::The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0518-2
更新日期:2018-04-01 00:00:00
abstract::Olfactory perception and learning play a vital role in the animal's entire life for habituation and survival. Insulin and insulin receptor signaling is well known to modulate the olfactory function and is also involved in the regulation of neurogenesis. A very high density of insulin receptors is present in the olfact...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02185-w
更新日期:2020-10-29 00:00:00
abstract::Recently, we reported a correlation of scopolamine mediated decline in memory consolidation with increase in the expression of DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) in the mouse hippocampus. Memory consolidation is a protein synthesis-dependent process which involves the expression of synap...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0047-4
更新日期:2017-09-01 00:00:00
abstract::During development, neurons migrate to the cortex radially from periventricular germinative zones as well as tangentially from ganglionic eminences. The vast majority of cortical neurons settle radially in the cortical plate. Neuronal migration requires an exquisite regulation of leading edge extension, nuclear transl...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:30:3:225
更新日期:2004-12-01 00:00:00
abstract::OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1383-3
更新日期:2019-07-01 00:00:00
abstract::The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8828-0
更新日期:2015-01-01 00:00:00
abstract::Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1088-7
更新日期:2019-01-01 00:00:00
abstract::Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02086-y
更新日期:2021-01-01 00:00:00
abstract::Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0596-1
更新日期:2018-05-01 00:00:00
abstract::P2C-type ATPases are a subfamily of P-type ATPases comprising Na(+)/K(+)-ATPase and H(+)/K(+)-ATPase. Na(+)/K(+)-ATPase is ubiquitously expressed and has been implicated in several neurological diseases, whereas H(+)/K(+)-ATPase is found principally in the colon, stomach, and kidney. Both ATPases have two subunits, α ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-9076-z
更新日期:2016-03-01 00:00:00
abstract::A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9541-3
更新日期:2016-11-01 00:00:00
abstract::Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01722-6
更新日期:2020-01-01 00:00:00