Abstract:
:P2C-type ATPases are a subfamily of P-type ATPases comprising Na(+)/K(+)-ATPase and H(+)/K(+)-ATPase. Na(+)/K(+)-ATPase is ubiquitously expressed and has been implicated in several neurological diseases, whereas H(+)/K(+)-ATPase is found principally in the colon, stomach, and kidney. Both ATPases have two subunits, α and β, but Na(+)/K(+)-ATPase also has a regulatory subunit called FXYD, which has an important role in cancer. The most important functions of these ATPases are homeostasis, potassium regulation, and maintaining a gradient in different cell types, like epithelial cells. Na(+)/K(+)-ATPase has become a center of attention ever since it was proposed that it might play a crucial role in neurological disorders such as bipolar disorder, mania, depression, familial hemiplegic migraine, rapid-onset dystonia parkinsonism, chronic stress, epileptogenesis, and Alzheimer's disease. On the other hand, it has been reported that lithium could have a neuroprotective effect against ouabain, which is the best known Na(+)/K(+)-ATPase inhibitor, but and high concentrations of lithium could affect negatively H(+)/K(+)-ATPase activity, that has a key role in regulating acidosis and potassium deficiencies. Finally, potassium homeostasis regulation is composed of two main mechanisms, extrarenal and renal. Extrarenal mechanism controls plasma levels, shifting potassium from the extracellular to the intracellular, whereas renal mechanism concerns with body balance and is influenced by potassium intake and its urinary excretion. In this article, we discuss the functions, isoforms, and localization of P2C-type ATPases, describe some of their modulators, and discuss their implications in some diseases.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Retamales-Ortega R,Vio CP,Inestrosa NCdoi
10.1007/s12035-014-9076-zsubject
Has Abstractpub_date
2016-03-01 00:00:00pages
1343-1354issue
2eissn
0893-7648issn
1559-1182pii
10.1007/s12035-014-9076-zjournal_volume
53pub_type
杂志文章,评审abstract::Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02086-y
更新日期:2021-01-01 00:00:00
abstract::Preconditioning with volatile anesthetics can create an ischemia tolerance against cerebral ischemia-reperfusion injury. We investigated whether ubiquitin conjugase 9 (Ubc9), the E2 conjugase for SUMOylation, is associated with neuroprotection induced by isoflurane preconditioning (IsoPC). In vitro, Ubc9 protein expre...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8797-3
更新日期:2015-01-01 00:00:00
abstract::Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0726-9
更新日期:2018-01-01 00:00:00
abstract::α-Synuclein aggregation contributes to the Parkinson's disease (PD) pathology in multiple ways-the two most important being the activation of neuroinflammation and mitochondrial dysfunction. Our recent studies have shown the beneficial effects of a heat shock protein (HSP) inducer, carbenoxolone (Cbx), in reducing the...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8769-7
更新日期:2015-02-01 00:00:00
abstract::Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still u...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1012-1
更新日期:2018-11-01 00:00:00
abstract::Tourette syndrome (TS) is a childhood-onset neurological disorder. To date, accurate TS diagnosis remains challenging due to its varied clinical expressions and dependency on qualitative description of symptoms. Therefore, identifying accurate and objective neuroimaging biomarkers may help improve early TS diagnosis. ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0519-1
更新日期:2018-04-01 00:00:00
abstract::Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-011-8175-3
更新日期:2011-06-01 00:00:00
abstract::Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8779-5
更新日期:2015-04-01 00:00:00
abstract::Accumulating evidences indicate that endogenous modulators of excitatory synapses in the mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed, glutamatergic and adenosinergic neurotransmissions were recently highlighted as potential targets for developing innovative anxiolytic drugs. A...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9660-x
更新日期:2017-01-01 00:00:00
abstract::Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9750-4
更新日期:2017-05-01 00:00:00
abstract::γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment o...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0705-1
更新日期:2018-06-01 00:00:00
abstract::An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...
journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12035-014-8944-x
更新日期:2015-12-01 00:00:00
abstract::Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0461-2
更新日期:2018-03-01 00:00:00
abstract::Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8374-6
更新日期:2013-04-01 00:00:00
abstract::Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation channels that form the predominant excitatory neurotransmitter receptors on muscles and nerves in the peripheral nervous system. AChRs are also expressed on neurons in lower amounts throughout the central nervous system. AChRs are eve...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740634
更新日期:1997-10-01 00:00:00
abstract::Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1157-y
更新日期:2019-02-01 00:00:00
abstract::There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0795-9
更新日期:2018-07-01 00:00:00
abstract::Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9001-5
更新日期:2016-01-01 00:00:00
abstract::Hippocampus-dependent memories, such as social recognition (SRM), are modulated by neurogenesis. However, the precise role of newborn neurons in social memory processing is still unknown. We showed previously that 1 week of enriched environment (EE) is sufficient to increase neurogenesis in the hippocampus (HIP) and t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9922-2
更新日期:2017-07-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0322-4
更新日期:2017-12-01 00:00:00
abstract::The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellular concentration of cAMP and Ca2+. This review examines the mechanisms by which these second messengers control transcriptional ini...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:30:1:091
更新日期:2004-08-01 00:00:00
abstract::(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9924-0
更新日期:2017-07-01 00:00:00
abstract::The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0518-2
更新日期:2018-04-01 00:00:00
abstract::Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0275-7
更新日期:2017-12-01 00:00:00
abstract::Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1625-z
更新日期:2019-11-01 00:00:00
abstract::Nicotine has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unknown....
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8874-7
更新日期:2015-08-01 00:00:00
abstract::Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02780606
更新日期:1993-04-01 00:00:00
abstract::Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study, an AD mouse m...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02064-4
更新日期:2020-11-01 00:00:00
abstract::Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01701-x
更新日期:2020-01-01 00:00:00
abstract::Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740601
更新日期:1998-02-01 00:00:00