Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum.

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Polyglutamine [poly(Q)] disorders are a class of trinucleotide repeat expansion neurodegenerative disorders which are dominantly inherited and progressively acquired with age. This group of disorders entail the characteristic formation of protein aggregates leading to widespread loss of neurons in different regions of...

journal_title：Molecular neurobiology

authors： Raj K,Sarkar S

更新日期：2019-02-01 00:00:00

abstract：:Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...

journal_title：Molecular neurobiology

authors： Montenegro-Burke JR,Woldstad CJ,Fang M,Bade AN,McMillan J,Edagwa B,Boska MD,Gendelman HE,Siuzdak G

更新日期：2019-04-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...

journal_title：Molecular neurobiology

authors： Eskandari-Sedighi G,Cortez LM,Yang J,Daude N,Shmeit K,Sim V,Westaway D

更新日期：2021-01-01 00:00:00

abstract：:We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...

journal_title：Molecular neurobiology

authors： Ahn SM,Kim YR,Shin YI,Ha KT,Lee SY,Shin HK,Choi BT

更新日期：2019-01-01 00:00:00

abstract：:Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...

journal_title：Molecular neurobiology

authors： Mele M,Morelli S,Fazzari G,Avolio E,Alò R,Piscioneri A,De Bartolo L,Facciolo RM,Canonaco M

更新日期：2017-11-01 00:00:00

abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...

journal_title：Molecular neurobiology

authors： Alvarez-Ricartes N,Oliveros-Matus P,Mendoza C,Perez-Urrutia N,Echeverria F,Iarkov A,Barreto GE,Echeverria V

更新日期：2018-10-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...

journal_title：Molecular neurobiology

authors： Lnenicka GA,Hong SJ

更新日期：1997-02-01 00:00:00

abstract：:The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...

journal_title：Molecular neurobiology

authors： Sánchez-Blázquez P,Pozo-Rodrigálvarez A,Merlos M,Garzón J

更新日期：2018-06-01 00:00:00

abstract：:During development, neurons migrate to the cortex radially from periventricular germinative zones as well as tangentially from ganglionic eminences. The vast majority of cortical neurons settle radially in the cortical plate. Neuronal migration requires an exquisite regulation of leading edge extension, nuclear transl...

journal_title：Molecular neurobiology

authors： Jossin Y

更新日期：2004-12-01 00:00:00

abstract：:Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultim...

journal_title：Molecular neurobiology

authors： Paredes MF,Baraban SC

更新日期：2002-08-01 00:00:00

abstract：:Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...

journal_title：Molecular neurobiology

authors： Du F,Qian ZM,Luo Q,Yung WH,Ke Y

更新日期：2015-08-01 00:00:00

abstract：:Many neurotransmitters and hormones activate receptors that are known to be coupled to their effectors by GTP-binding regulatory proteins, G proteins. Activation of many of these same receptors elicits arachidonate release and metabolism. During the past few years, novel experimental techniques have revealed that in m...

journal_title：Molecular neurobiology

authors： Burch RM

更新日期：1989-10-01 00:00:00

abstract：:In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that this transcription factor plays a critical role in integrating different inputs and mediating appropriate neuronal responses. The nature of this transcriptional re...

journal_title：Molecular neurobiology

authors： Barco A,Marie H

更新日期：2011-12-01 00:00:00

abstract：:Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribute to the pathogenesis of Parkinson's disease (PD) and several other n...

journal_title：Molecular neurobiology

authors： Silva BA,Breydo L,Fink AL,Uversky VN

更新日期：2013-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are enzymes that catalyze the transfer of ADP-ribose units from β-nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins. PARP-1 is responsible for more than 90 % of protein poly-ADP-ribosylation in the brain and may play a role as a molecular switch for cell survival and ...

journal_title：Molecular neurobiology

authors： Banasik M,Stedeford T,Strosznajder RP

更新日期：2012-08-01 00:00:00

abstract：:Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...

journal_title：Molecular neurobiology

authors： Corpas R,Griñán-Ferré C,Rodríguez-Farré E,Pallàs M,Sanfeliu C

更新日期：2019-02-01 00:00:00

abstract：:Hypertension is one of the co-morbid conditions for stroke and profoundly increases its incidence. Angiotensin II (AngII) is shown to be at the center stage in driving the renin angiotensin system via activation of angiotensin 1 receptor (AT1R). This makes the AT1R gene one of the candidates whose differential regulat...

journal_title：Molecular neurobiology

authors： Jain S,Tulsulkar J,Rana A,Kumar A,Shah ZA

更新日期：2016-04-01 00:00:00

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...

journal_title：Molecular neurobiology

authors： Vohra R,Kolko M

更新日期：2020-04-01 00:00:00

abstract：:In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...

journal_title：Molecular neurobiology

authors： Castruccio Castracani C,Longhitano L,Distefano A,Di Rosa M,Pittalà V,Lupo G,Caruso M,Corona D,Tibullo D,Li Volti G

更新日期：2020-05-01 00:00:00

abstract：:Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...

journal_title：Molecular neurobiology

authors： Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Budzynska B

更新日期：2017-03-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00

abstract：:Prion pathologies are characterized by the conformational conversion of the cellular prion protein (PrPC) into a pathological infectious isoform, known as PrPSc. The latter acquires different abnormal conformations, which are associated with specific pathological phenotypes. Recent evidence suggests that prions adapt ...

journal_title：Molecular neurobiology

authors： Bistaffa E,Moda F,Virgilio T,Campagnani I,De Luca CMG,Rossi M,Salzano G,Giaccone G,Tagliavini F,Legname G

更新日期：2019-04-01 00:00:00

abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00

abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...

journal_title：Molecular neurobiology

authors： Bu XL,Rao PPN,Wang YJ

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild st...

journal_title：Molecular neurobiology

authors： Shang X,Shang Y,Fu J,Zhang T

更新日期：2017-08-01 00:00:00

abstract：:Oxidative damage to the inner ear is responsible for several types of sensorineural deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative stress. Activated poly(ADP-ribose) polymerase 1 (PARP1) has been implicated in several diseases, but the effect of PARP1 on MCs subjected to o...

journal_title：Molecular neurobiology

authors： Zhang Y,Yang Y,Xie Z,Zuo W,Jiang H,Zhao X,Sun Y,Kong W

更新日期：2016-11-01 00:00:00

abstract：:Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...

journal_title：Molecular neurobiology

authors： Yang X,Askarova S,Lee JC

更新日期：2010-06-01 00:00:00

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00