The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.

Abstract:

:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 in various animal models of cortical development have highlighted conserved functions in brain growth. Here, we provide a timely review of our current understanding of WDR62 contributions in the self-renewal, expansion and fate specification of neural stem and progenitor cells that are critical for neocortical development. Recent studies have revealed multiple functions for WDR62 in the regulation of spindle organization, mitotic progression and the duplication and biased inheritance of centrosomes during asymmetric divisions. We also discuss recently elaborated WDR62 interaction partners that include Aurora and c-Jun N-terminal kinases as part of complex signalling mechanisms that may define its neural functions. These studies provide new insights into the molecular and cellular processes that are required for brain formation and implicated in the genesis of primary microcephaly.

journal_name

Mol Neurobiol

journal_title

Molecular neurobiology

authors

Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

doi

10.1007/s12035-017-0778-x

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

5409-5424

issue

7

eissn

0893-7648

issn

1559-1182

pii

10.1007/s12035-017-0778-x

journal_volume

55

pub_type

杂志文章,评审
  • Subcellular Parkinson's Disease-Specific Alpha-Synuclein Species Show Altered Behavior in Neurodegeneration.

    abstract::Parkinson's disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered an intrinsically disordered 14 kDa monomer, and although poorly understood, its transition to higher-order multimeric species...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-016-0266-8

    authors: Abdullah R,Patil KS,Rosen B,Pal R,Prabhudesai S,Lee S,Basak I,Hoedt E,Yang P,Panick K,Ho HP,Chang E,Tzoulis C,Larsen JP,Neubert TA,Alves G,Møller SG

    更新日期:2017-12-01 00:00:00

  • Neuropsin Expression Correlates with Dendritic Marker MAP2c Level in Different Brain Regions of Aging Mice.

    abstract::Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-014-8780-z

    authors: Konar A,Thakur MK

    更新日期:2015-01-01 00:00:00

  • HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.

    abstract::The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-015-9644-x

    authors: García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

    更新日期:2017-01-01 00:00:00

  • Infantile Amnesia Is Related to Developmental Immaturity of the Maintenance Mechanisms for Long-Term Potentiation.

    abstract::Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-018-1119-4

    authors: Tsai TC,Huang CC,Hsu KS

    更新日期:2019-02-01 00:00:00

  • Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme.

    abstract::Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-018-0978-z

    authors: Jindal V

    更新日期:2018-11-01 00:00:00

  • The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-018-1211-9

    authors: Garcez ML,Mina F,Bellettini-Santos T,da Luz AP,Schiavo GL,Macieski JMC,Medeiros EB,Marques AO,Magnus NQ,Budni J

    更新日期:2019-04-01 00:00:00

  • Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?

    abstract::The gammaretroviral human endogenous retrovirus (HERV) families MRSV/HERV-W and HERV-H (including the closely related HERV-Fc1) are associated with an increased risk of multiple sclerosis (MS). Complete HERV sequences betray their endogenous retroviral origin, with open reading frames in gag, pro, pol and env being fl...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-018-1255-x

    authors: Morris G,Maes M,Murdjeva M,Puri BK

    更新日期:2019-04-01 00:00:00

  • Dietary Linoleic Acid Lowering Reduces Lipopolysaccharide-Induced Increase in Brain Arachidonic Acid Metabolism.

    abstract::Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-016-9968-1

    authors: Taha AY,Blanchard HC,Cheon Y,Ramadan E,Chen M,Chang L,Rapoport SI

    更新日期:2017-08-01 00:00:00

  • From hindbrain segmentation to breathing after birth: developmental patterning in rhombomeres 3 and 4.

    abstract::Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated within central pattern-generating neuronal networks of the hindbrain. This region of the brain is of particular interest since it is the most understood part with respect to the cellular and mol...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1385/mn:28:3:277

    authors: Chatonnet F,Domínguez del Toro E,Thoby-Brisson M,Champagnat J,Fortin G,Rijli FM,Thaëron-Antôno C

    更新日期:2003-12-01 00:00:00

  • Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death.

    abstract::Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-015-9275-2

    authors: Lu YM,Gao YP,Tao RR,Liao MH,Huang JY,Wu G,Han F,Li XM

    更新日期:2016-05-01 00:00:00

  • Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells.

    abstract::Prenatal ethanol exposure can cause extensive apoptotic neurodegeneration throughout the developing central nervous system (CNS), which results in cognitive deficits and memory decline. However, the underlying mechanisms need further study. Single-minded 2 (Sim2), a transcriptional repressor, is reportedly involved in...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-014-8924-1

    authors: Wang X,Yang Z,Sun Y,Zhou H,Chu G,Zhang J,Meng X

    更新日期:2015-12-01 00:00:00

  • Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3.

    abstract::Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-015-9587-2

    authors: Davis SM,Collier LA,Leonardo CC,Seifert HA,Ajmo CT Jr,Pennypacker KR

    更新日期:2017-01-01 00:00:00

  • Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice.

    abstract::The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that helps regulate inflammatory pain sensation and nociception and the development of inflammatory diseases. However, the potential role of the TRPA1 channel and the underlying mechanism in brain functions are not fully resol...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-016-9908-0

    authors: Lee KI,Lin HC,Lee HT,Tsai FC,Lee TS

    更新日期:2017-07-01 00:00:00

  • Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.

    abstract::Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-015-9423-8

    authors: Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

    更新日期:2016-10-01 00:00:00

  • Changes in transcriptional factor binding capacity resulting from promoter region methylation induce aberrantly high GDNF expression in human glioma.

    abstract::Glial cell line-derived neurotrophic factor (GDNF), which belongs to transforming growth factor β superfamily, plays important roles in glioma pathogenesis. Gdnf mRNA is aberrantly increased in glioma cells, but the underlying transcription mechanism is unclear. Here, we found that although the base sequence in the pr...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-013-8443-5

    authors: Yu ZQ,Zhang BL,Ren QX,Wang JC,Yu RT,Qu DW,Liu ZH,Xiong Y,Gao DS

    更新日期:2013-12-01 00:00:00

  • Vitamin B6 Reduces Neurochemical and Long-Term Cognitive Alterations After Polymicrobial Sepsis: Involvement of the Kynurenine Pathway Modulation.

    abstract::Neurological dysfunction as a result of neuroinflammation has been reported in sepsis and cause high mortality. High levels of cytokines stimulate the formation of neurotoxic metabolites by kynurenine (KYN) pathway. Vitamin B6 (vit B6) has anti-inflammatory and antioxidant properties and also acts as a cofactor for en...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-017-0706-0

    authors: Danielski LG,Giustina AD,Goldim MP,Florentino D,Mathias K,Garbossa L,de Bona Schraiber R,Laurentino AOM,Goulart M,Michels M,de Queiroz KB,Kohlhof M,Rezin GT,Fortunato JJ,Quevedo J,Barichello T,Dal-Pizzol F,Coimbra RS,

    更新日期:2018-06-01 00:00:00

  • Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress.

    abstract::Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-018-1273-8

    authors: Montenegro-Burke JR,Woldstad CJ,Fang M,Bade AN,McMillan J,Edagwa B,Boska MD,Gendelman HE,Siuzdak G

    更新日期:2019-04-01 00:00:00

  • N-methyl-D-aspartate receptors in the retina.

    abstract::The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1385/MN:34:3:163

    authors: Shen Y,Liu XL,Yang XL

    更新日期:2006-12-01 00:00:00

  • Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists.

    abstract::Astrocytes comprise the major cell type in the central nervous system (CNS) and they are essential for support of neuronal functions by providing nutrients and regulating cell-to-cell communication. Astrocytes also are immune-like cells that become reactive in response to neuronal injury. Phospholipases A2 (PLA2) are ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1385/MN:31:1-3:027

    authors: Sun GY,Xu J,Jensen MD,Yu S,Wood WG,González FA,Simonyi A,Sun AY,Weisman GA

    更新日期:2005-01-01 00:00:00

  • Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach.

    abstract::Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patients. On the histological level, acute axonal injury is most frequently analyzed by anti-amyloid precursor protein immunohistochemistry. To what extent this method truly detects axonal injury, and whether other proteins ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-018-1353-9

    authors: Rühling S,Kramer F,Schmutz S,Amor S,Jiangshan Z,Schmitz C,Kipp M,Hochstrasser T

    更新日期:2019-06-01 00:00:00

  • Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection.

    abstract::The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-molecular-weight drugs could be a feasible alternative for the direct administration of neurotrophic factors for the treatment of central nervous system disorders. Recent data suggest that several drugs already in clinical use...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1385/MN:29:3:289

    authors: Castrén E

    更新日期:2004-06-01 00:00:00

  • Conditioned Medium Derived from Neural Progenitor Cells Induces Long-term Post-ischemic Neuroprotection, Sustained Neurological Recovery, Neurogenesis, and Angiogenesis.

    abstract::Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-016-9748-y

    authors: Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

    更新日期:2017-03-01 00:00:00

  • Emerging Trends in Retrograde Signaling.

    abstract::Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-015-9280-5

    authors: Suvarna Y,Maity N,Shivamurthy MC

    更新日期:2016-05-01 00:00:00

  • Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus.

    abstract::Morphine as an opioid is an important drug in the treatment of moderate to severe pain. Several stress factors via generation of nitric oxide (NO) and oxidative stress (OS) are responsible for the adverse effects of morphine-induced analgesia, addiction, and antinociceptive tolerance, including altered Ca2+ concentrat...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-020-01975-6

    authors: Osmanlıoğlu HÖ,Yıldırım MK,Akyuva Y,Yıldızhan K,Nazıroğlu M

    更新日期:2020-08-01 00:00:00

  • Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives.

    abstract::Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamin...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-018-1419-8

    authors: Jamebozorgi K,Taghizadeh E,Rostami D,Pormasoumi H,Barreto GE,Hayat SMG,Sahebkar A

    更新日期:2019-07-01 00:00:00

  • Potential Roles of Myeloid Differentiation Factor 2 on Neuroinflammation and Its Possible Interventions.

    abstract::Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-020-02066-2

    authors: Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

    更新日期:2020-11-01 00:00:00

  • Towards a TDP-43-Based Biomarker for ALS and FTLD.

    abstract::TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审

    doi:10.1007/s12035-018-0947-6

    authors: Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

    更新日期:2018-10-01 00:00:00

  • Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.

    abstract::Addiction is a chronic psychiatric disease which represents a global problem, and stress can increase drug addiction and relapse. Taking into account frequent concomitance of nicotine dependence and stress, the purpose of the present study was to assess behavioral and biochemical effects of chronic unpredictable mild ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-017-0585-4

    authors: Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Grot K,Budzynska B

    更新日期:2018-04-01 00:00:00

  • Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke.

    abstract::Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-016-9903-5

    authors: Sun L,Tian L,Xu J,Zhang Z,Liu X

    更新日期:2017-07-01 00:00:00

  • Glutamate regulates the activity of topoisomerase I in mouse cerebellum.

    abstract::Topoisomerase I (topo I) is a nuclear enzyme which participates in most DNA transactions. It was shown to be inhibited in depolarized neurons by poly adenosine diphosphate (ADP)-ribosylation of the enzyme protein. We demonstrated previously an age and sex dependent topo I activity and enzyme protein level in the vario...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章

    doi:10.1007/s12035-008-8044-x

    authors: Zehorai E,Eitan E,Hershfinkel M,Sekler I,Priel E

    更新日期:2008-12-01 00:00:00