Correction to: Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.

abstract：:The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-molecular-weight drugs could be a feasible alternative for the direct administration of neurotrophic factors for the treatment of central nervous system disorders. Recent data suggest that several drugs already in clinical use...

journal_title：Molecular neurobiology

authors： Castrén E

更新日期：2004-06-01 00:00:00

abstract：:The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...

journal_title：Molecular neurobiology

authors： Semple E,Shalabi F,Hill JW

更新日期：2019-09-01 00:00:00

abstract：:Long-term potentiation (LTP) is a cellular model for learning and memory and believed to be critical for plastic changes in the brain. Depending on the central nervous system region, LTP has been proposed to contribute to many key physiological functions and pathological conditions, such as learning/memory, chronic pa...

journal_title：Molecular neurobiology

authors： Descalzi G,Kim S,Zhuo M

更新日期：2009-12-01 00:00:00

abstract：:Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs although with adve...

journal_title：Molecular neurobiology

authors： Gordillo-Salas M,Pascual-Antón R,Ren J,Greer J,Adell A

更新日期：2020-08-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...

journal_title：Molecular neurobiology

authors： Ribeiro FM,Pires RG,Ferguson SS

更新日期：2011-02-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...

journal_title：Molecular neurobiology

authors： Liou CJ,Yang CM,Lee TH,Liu PS,Hsieh HL

更新日期：2019-01-01 00:00:00

abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

journal_title：Molecular neurobiology

authors： García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

更新日期：2017-01-01 00:00:00

abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...

journal_title：Molecular neurobiology

authors： Cairns BE,O'Brien M,Dong XD,Gazerani P

更新日期：2017-07-01 00:00:00

abstract：:The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input-output connections, and time of neurogenesis. Since it is thought that limbic, reward-related information and executive aspects of behavioral information may be differentially p...

journal_title：Molecular neurobiology

authors： Miura M,Masuda M,Aosaki T

更新日期：2008-04-01 00:00:00

abstract：:Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...

journal_title：Molecular neurobiology

authors： Prestigio C,Ferrante D,Valente P,Casagrande S,Albanesi E,Yanagawa Y,Benfenati F,Baldelli P

更新日期：2019-09-01 00:00:00

abstract：:Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...

journal_title：Molecular neurobiology

authors： Tibullo D,Giallongo C,Puglisi F,Tomassoni D,Camiolo G,Cristaldi M,Brundo MV,Anfuso CD,Lupo G,Stampone T,Li Volti G,Amenta F,Avola R,Bramanti V

更新日期：2018-04-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...

journal_title：Molecular neurobiology

authors： Souslova T,Mirédin K,Millar AM,Albert PR

更新日期：2017-12-01 00:00:00

abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...

journal_title：Molecular neurobiology

authors： Velasco G,Carracedo A,Blázquez C,Lorente M,Aguado T,Haro A,Sánchez C,Galve-Roperh I,Guzmán M

更新日期：2007-08-01 00:00:00

abstract：:Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information processing in the brain. The growth and complexity of dendritic arbors are driven by the formation of synapses alo...

journal_title：Molecular neurobiology

authors： Lira M,Arancibia D,Orrego PR,Montenegro-Venegas C,Cruz Y,García J,Leal-Ortiz S,Godoy JA,Gundelfinger ED,Inestrosa NC,Garner CC,Zamorano P,Torres VI

更新日期：2019-07-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....

journal_title：Molecular neurobiology

authors： Mullin AP,Gokhale A,Larimore J,Faundez V

更新日期：2011-08-01 00:00:00

abstract：:The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible use of sympathetic thoracic ganglia from subjects after brain death as study group. The third left ...

journal_title：Molecular neurobiology

authors： de Moura Júnior NB,das-Neves-Pereira JC,de Campos JR,de Oliveira FR,Wolosker N,Parra ER,Capelozzi VL,Jatene FB

更新日期：2012-04-01 00:00:00

abstract：:AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulato...

journal_title：Molecular neurobiology

authors： Wu Y,Ly PT,Song W

更新日期：2014-12-01 00:00:00

abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...

journal_title：Molecular neurobiology

authors： Zendedel A,Johann S,Mehrabi S,Joghataei MT,Hassanzadeh G,Kipp M,Beyer C

更新日期：2016-07-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00

abstract：:Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to ...

journal_title：Molecular neurobiology

authors： Geranmayeh MH,Nourazarian A,Avci ÇB,Rahbarghazi R,Farhoudi M

更新日期：2017-12-01 00:00:00

abstract：:γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment o...

journal_title：Molecular neurobiology

authors： Sogorb-Esteve A,García-Ayllón MS,Llansola M,Felipo V,Blennow K,Sáez-Valero J

更新日期：2018-06-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...

journal_title：Molecular neurobiology

authors： Perianes-Cachero A,Lobo MVT,Hernández-Pinto AM,Busto R,Lasunción-Ripa MA,Arilla-Ferreiro E,Puebla-Jiménez L

更新日期：2020-02-01 00:00:00

abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...

journal_title：Molecular neurobiology

authors： Zhang J,Shipston MJ,Brown SB

更新日期：2010-08-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Oxidative stress-induced damage is a major mechanism in the pathophysiology of amyotrophic lateral sclerosis (ALS). A recent human clinical trial showed that the combination of nicotinamide riboside (NR) and pterostilbene (PT), molecules with potential to interfere in that mechanism, was efficacious in ALS patients. W...

journal_title：Molecular neurobiology

authors： Obrador E,Salvador R,Marchio P,López-Blanch R,Jihad-Jebbar A,Rivera P,Vallés SL,Banacloche S,Alcácer J,Colomer N,Coronado JA,Alandes S,Drehmer E,Benlloch M,Estrela JM

更新日期：2020-11-10 00:00:00

abstract：:Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...

journal_title：Molecular neurobiology

authors： Du F,Qian ZM,Luo Q,Yung WH,Ke Y

更新日期：2015-08-01 00:00:00