Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement.

abstract：:Polyglutamine [poly(Q)] disorders are a class of trinucleotide repeat expansion neurodegenerative disorders which are dominantly inherited and progressively acquired with age. This group of disorders entail the characteristic formation of protein aggregates leading to widespread loss of neurons in different regions of...

journal_title：Molecular neurobiology

authors： Raj K,Sarkar S

更新日期：2019-02-01 00:00:00

abstract：:Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...

journal_title：Molecular neurobiology

authors： Weise SC,Arumugam G,Villarreal A,Videm P,Heidrich S,Nebel N,Dumit VI,Sananbenesi F,Reimann V,Craske M,Schilling O,Hess WR,Fischer A,Backofen R,Vogel T

更新日期：2019-07-01 00:00:00

abstract：:Resveratrol (RSV) is anti-inflammatory and neuroprotective, cross the blood-brain barrier (BBB) and has a safe profile. Besides, RSV modulates the expression of some miRNAs related to neurological disorders. Thus, we hypothesized that RSV can be neuroprotective in pneumococcal meningitis by modulating the global micro...

journal_title：Molecular neurobiology

authors： de Queiroz KB,Dos Santos Fontes Pereira T,Araújo MSS,Gomez RS,Coimbra RS

更新日期：2018-12-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...

journal_title：Molecular neurobiology

authors： Boutin H,Kimber I,Rothwell NJ,Pinteaux E

更新日期：2003-06-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, th...

journal_title：Molecular neurobiology

authors： Fu R,Shen Q,Xu P,Luo JJ,Tang Y

更新日期：2014-06-01 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:Excess production of reactive oxygen species in the brain has been implicated as a common underlying risk factor for the pathogenesis of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In recent years, there is considerable interest concerning investig...

journal_title：Molecular neurobiology

authors： Sun AY,Wang Q,Simonyi A,Sun GY

更新日期：2010-06-01 00:00:00

abstract：:The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especia...

journal_title：Molecular neurobiology

authors： Schaffer S,Asseburg H,Kuntz S,Muller WE,Eckert GP

更新日期：2012-08-01 00:00:00

abstract：:B-50 (GAP-43) is an axonal, plasma membrane-associated protein involved in growth cone morphology and function. We have conducted immunocytochemical, electron microscopic, and time-lapse experiments to visualize morphological consequences of local accumulations of B-50 at the plasma membrane of B-50-transfected PC-B2 ...

journal_title：Molecular neurobiology

authors： Aarts LH,Verkade P,Schrama LH,Oestreicher AB,Gispen WH,Schotman P

更新日期：1999-08-01 00:00:00

abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...

journal_title：Molecular neurobiology

authors： Serratto GM,Pizzi E,Murru L,Mazzoleni S,Pelucchi S,Marcello E,Mazzanti M,Passafaro M,Bassani S

更新日期：2020-12-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00

abstract：:Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal-lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderato...

journal_title：Molecular neurobiology

authors： Cordaro M,Paterniti I,Siracusa R,Impellizzeri D,Esposito E,Cuzzocrea S

更新日期：2017-05-01 00:00:00

abstract：:The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...

journal_title：Molecular neurobiology

authors： Semple E,Shalabi F,Hill JW

更新日期：2019-09-01 00:00:00

abstract：:In this study, we investigated the influence of elevated RAS expression on the growth of meningioma in vivo and in vitro. The IOMM-LEE cells, representing a cell line derived from malignant meningioma, were divided into blank control group (cells without any drug treatment), negative control group (cells treated with ...

journal_title：Molecular neurobiology

authors： Jiang C,Song T,Li J,Ao F,Gong X,Lu Y,Zhang C,Chen L,Liu Y,He H,Huang O

更新日期：2017-01-01 00:00:00

abstract：:This article reviews a lecture I was honored to present at the Leon Wolfe Symposium in Montreal on March 25, 2004. The lecture described my research career, which started with my interaction with Wolfe at the Montreal Neurological Institute as a postdoctoral fellow and research associate and was followed by additional...

journal_title：Molecular neurobiology

authors： Pace-Asciak CR

更新日期：2005-08-01 00:00:00

abstract：:Expression changes for long non-coding RNAs (lncRNAs) have been identified in adult glioblastoma multiforme (GBM) and in a mixture of adult and pediatric astrocytoma. Since adult and pediatric astrocytomas are molecularly different, the mixture of both could mask specific features in each. We determined the global exp...

journal_title：Molecular neurobiology

authors： Ruiz Esparza-Garrido R,Rodríguez-Corona JM,López-Aguilar JE,Rodríguez-Florido MA,Velázquez-Wong AC,Viedma-Rodríguez R,Salamanca-Gómez F,Velázquez-Flores MÁ

更新日期：2017-10-01 00:00:00

abstract：:Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contex...

journal_title：Molecular neurobiology

authors： Jiang L,Mao R,Zhou Q,Yang Y,Cao J,Ding Y,Yang Y,Zhang X,Li L,Xu L

更新日期：2016-03-01 00:00:00

abstract：:Ginsenoside Rg1 is efficient to prevent or treat mental disorders. However, the mechanisms underlying the effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD) are still not known. In this study, single-prolonged stress (SPS) regime, as well as injection of lipopolysaccharide (LPS), was used to produce P...

journal_title：Molecular neurobiology

authors： Zhang Z,Song Z,Shen F,Xie P,Wang J,Zhu AS,Zhu G

更新日期：2020-11-19 00:00:00

abstract：:Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently, the unfolded protein response (UPR) has been shown to be involved in r...

journal_title：Molecular neurobiology

authors： Timberlake Ii M,Roy B,Dwivedi Y

更新日期：2019-12-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...

journal_title：Molecular neurobiology

authors： Zhong S,Zhao Z,Xie W,Cai Y,Zhang Y,Ding J,Wang X

更新日期：2021-01-01 00:00:00

abstract：:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...

journal_title：Molecular neurobiology

authors： Sochocka M,Donskow-Łysoniewska K,Diniz BS,Kurpas D,Brzozowska E,Leszek J

更新日期：2019-03-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00

abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...

journal_title：Molecular neurobiology

authors： Beker MC,Caglayan B,Yalcin E,Caglayan AB,Turkseven S,Gurel B,Kelestemur T,Sertel E,Sahin Z,Kutlu S,Kilic U,Baykal AT,Kilic E

更新日期：2018-03-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...

journal_title：Molecular neurobiology

authors： Wang W,Wang F,Liu J,Zhao W,Zhao Q,He M,Qian BJ,Xu Y,Liu R,Liu SJ,Liu W,Liu J,Zhou XF,Wang TH

更新日期：2014-10-01 00:00:00

abstract：:Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...

journal_title：Molecular neurobiology

authors： Amtul Z,Yang J,Nikolova S,Lee TY,Bartha R,Cechetto DF

更新日期：2018-10-01 00:00:00

abstract：:The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-molecular-weight drugs could be a feasible alternative for the direct administration of neurotrophic factors for the treatment of central nervous system disorders. Recent data suggest that several drugs already in clinical use...

journal_title：Molecular neurobiology

authors： Castrén E

更新日期：2004-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...

journal_title：Molecular neurobiology

authors： Garcez ML,Mina F,Bellettini-Santos T,da Luz AP,Schiavo GL,Macieski JMC,Medeiros EB,Marques AO,Magnus NQ,Budni J

更新日期：2019-04-01 00:00:00