Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection.

abstract：:The potassium channel tetramerization domain-containing protein 7 (KCTD7) was named after the structural homology of its predicted N-terminal broad complex, tramtrack and bric à brac/poxvirus and zinc finger domain with the T1 domain of the Kv potassium channel, but its expression profile and cellular function are sti...

journal_title：Molecular neurobiology

authors： Azizieh R,Orduz D,Van Bogaert P,Bouschet T,Rodriguez W,Schiffmann SN,Pirson I,Abramowicz MJ

更新日期：2011-08-01 00:00:00

abstract：:Neuronal plasticity can be defined as adaptive changes in structure and function of the nervous system, an obvious example of which is the capacity to remember and learn. Long-term potentiation and long-term depression are the experimental models of memory in the central nervous system (CNS), and have been frequently ...

journal_title：Molecular neurobiology

authors： Tokuda M,Hatase O

更新日期：1998-01-01 00:00:00

abstract：:The epidermal growth factor (EGF) family of polypeptides is regulators for tissue development and repair, and is characterized by the fact that their mature forms are proteolytically derived from their integral membrane precursors. This article reviews roles of the prominent members of the EGF family (EGF, transformin...

journal_title：Molecular neurobiology

authors： Xian CJ,Zhou XF

更新日期：1999-10-01 00:00:00

abstract：:Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patients. On the histological level, acute axonal injury is most frequently analyzed by anti-amyloid precursor protein immunohistochemistry. To what extent this method truly detects axonal injury, and whether other proteins ...

journal_title：Molecular neurobiology

authors： Rühling S,Kramer F,Schmutz S,Amor S,Jiangshan Z,Schmitz C,Kipp M,Hochstrasser T

更新日期：2019-06-01 00:00:00

abstract：:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depres...

journal_title：Molecular neurobiology

authors： Aydin E,Hritcu L,Dogan G,Hayta S,Bagci E

更新日期：2016-11-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...

journal_title：Molecular neurobiology

authors： Zhong S,Zhao Z,Xie W,Cai Y,Zhang Y,Ding J,Wang X

更新日期：2021-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also possesses antioxidant activities. However, the underlying mechanisms remain to be fully defined. Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress. Currently, the potential functions of...

journal_title：Molecular neurobiology

authors： Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI

更新日期：2016-08-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable ...

journal_title：Molecular neurobiology

authors： Godoy JA,Valdivieso AG,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand...

journal_title：Molecular neurobiology

authors： Ferrero H,Larrayoz IM,Gil-Bea FJ,Martínez A,Ramírez MJ

更新日期：2018-12-01 00:00:00

abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...

journal_title：Molecular neurobiology

authors： Serratto GM,Pizzi E,Murru L,Mazzoleni S,Pelucchi S,Marcello E,Mazzanti M,Passafaro M,Bassani S

更新日期：2020-12-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal ...

journal_title：Molecular neurobiology

authors： Lima LCF,Saliba SW,Andrade JMO,Cunha ML,Cassini-Vieira P,Feltenberger JD,Barcelos LS,Guimarães ALS,de-Paula AMB,de Oliveira ACP,Santos SHS

更新日期：2017-07-01 00:00:00

abstract：:Arduous efforts have been made in the last three decades to elucidate the role of insulin in the brain. A growing number of evidences show that insulin is involved in several physiological function of the brain such as food intake and weight control, reproduction, learning and memory, neuromodulation and neuroprotecti...

journal_title：Molecular neurobiology

authors： Ghasemi R,Dargahi L,Haeri A,Moosavi M,Mohamed Z,Ahmadiani A

更新日期：2013-06-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Mül...

journal_title：Molecular neurobiology

authors： Wilkerson JL,Stiles MA,Gurley JM,Grambergs RC,Gu X,Elliott MH,Proia RL,Mandal NA

更新日期：2019-10-01 00:00:00

abstract：:Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...

journal_title：Molecular neurobiology

authors： Konar A,Thakur MK

更新日期：2015-01-01 00:00:00

abstract：:Intracerebroventricular (icv) amyloid-beta (Aβ)1-40 infusion to mice has been demonstrated to cause neurotoxicty and depressive-like behavior and it can be used to evaluate antidepressant and neuroprotective effect of drugs. Atorvastatin is a widely used statin that has demonstrated antidepressant-like effect in predi...

journal_title：Molecular neurobiology

authors： Ludka FK,Cunha MP,Dal-Cim T,Binder LB,Constantino LC,Massari CM,Martins WC,Rodrigues ALS,Tasca CI

更新日期：2017-10-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is the main intracellular pathway for modulated protein turnover, playing an important role in the maintenance of cellular homeostasis. It also exerts a protein quality control through degradation of oxidized, mutant, denatured, or misfolded proteins and is involved in many biolog...

journal_title：Molecular neurobiology

authors： Campello L,Esteve-Rudd J,Cuenca N,Martín-Nieto J

更新日期：2013-04-01 00:00:00

abstract：:Olfactory dysfunction is a recognized risk factor for the pathogenesis of Alzheimer's disease (AD), while the mechanisms are still not clear. Here, we applied bilateral olfactory bulbectomy (OBX), an olfactory deprivation surgery to cause permanent anosmia, in human tau-overexpressed mice (htau mice) to investigate ch...

journal_title：Molecular neurobiology

authors： Li K,Liu FF,He CX,Huang HZ,Xie AJ,Hu F,Liu D,Wang JZ,Zhu LQ

更新日期：2016-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...

journal_title：Molecular neurobiology

authors： Lu XL,Wang L,Chang SY,Shangguan SF,Wang Z,Wu LH,Zou JZ,Xiao P,Li R,Bao YH,Qiu ZY,Zhang T

更新日期：2016-10-01 00:00:00

abstract：:α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...

journal_title：Molecular neurobiology

authors： Wang Y,Gao A,Xu X,Dang B,You W,Li H,Yu Z,Chen G

更新日期：2015-08-01 00:00:00

abstract：:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...

journal_title：Molecular neurobiology

authors： Shin T,Ahn M,Moon C,Kim S,Sim KB

更新日期：2013-06-01 00:00:00

abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...

journal_title：Molecular neurobiology

authors： Zhang N,Yu X,Xie J,Xu H

更新日期：2021-01-28 00:00:00

abstract：:Since the discovery of leptin and the central melanocortin circuit, electrophysiological studies have played a major role in elucidating mechanisms underlying energy homeostasis. This review highlights the contribution of findings made by electrophysiological measurements to the current understanding of hypothalamic n...

journal_title：Molecular neurobiology

authors： Ghamari-Langroudi M

更新日期：2012-04-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...

journal_title：Molecular neurobiology

authors： Huang HJ,Wang YT,Lin HC,Lee YH,Lin AM

更新日期：2018-01-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...

journal_title：Molecular neurobiology

authors： Ribeiro FM,Pires RG,Ferguson SS

更新日期：2011-02-01 00:00:00

abstract：:Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...

journal_title：Molecular neurobiology

authors： Lu YM,Gao YP,Tao RR,Liao MH,Huang JY,Wu G,Han F,Li XM

更新日期：2016-05-01 00:00:00

abstract：:Myeloperoxidase (MPO) has paradoxically been found to be able to both activate matrix metalloproteinases (MMPs) as well as inhibit MMPs. However, these regulatory effects have not yet been observed in vivo, and it is unclear which pathway is relevant in vivo. We aim to track MPO regulation of MMP activity in living an...

journal_title：Molecular neurobiology

authors： Zhang Y,Dong H,Seeburg DP,Wojtkiewicz GR,Waterman P,Pulli B,Forghani R,Ali M,Iwamoto Y,Swirski FK,Chen JW

更新日期：2019-02-01 00:00:00