Abstract：
:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and PrP neurotoxicity in vitro, it remained unknown whether IVIG could reduce amyloid plaque pathology in vivo and be used to effectively treat animals with prion diseases. In this study, we used Gerstmann-Sträussler-Scheinker (GSS)-Tg (PrP-A116V) transgenic mice to test IVIG efficacy since amyloid plaque formation played an important role in GSS pathogenesis. Here, we provided strong evidence that demonstrates how IVIG could significantly delay disease onset, elongate survival, and improve clinical phenotype in Tg (PrP-A116V) mice. Additionally, in treated animals, IVIG could markedly inhibit PrP amyloid plaque formation and attenuate neuronal apoptosis at the age of 120 days in mice. Our results indicate that IVIG may be a potential, effective therapeutic treatment for GSS and other prion diseases.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Ydoi
10.1007/s12035-018-1228-0subject
Has Abstractpub_date
2019-04-01 00:00:00pages
2353-2361issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-018-1228-0journal_volume
56pub_type
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