Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway.

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...

journal_title：Molecular neurobiology

authors： Woods SD,Skinner RD,Ricca AM,Brown AT,Lowery JD,Borrelli MJ,Lay JO,Culp WC

更新日期：2013-10-01 00:00:00

abstract：:Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...

journal_title：Molecular neurobiology

authors： Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2012-08-01 00:00:00

abstract：:Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax+/- mice were used to test the hypothesis that lowering the quantity of BAX in RGCs...

journal_title：Molecular neurobiology

authors： Donahue RJ,Maes ME,Grosser JA,Nickells RW

更新日期：2020-02-01 00:00:00

abstract：:Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...

journal_title：Molecular neurobiology

authors： Brusco I,Silva CR,Trevisan G,de Campos Velho Gewehr C,Rigo FK,La Rocca Tamiozzo L,Rossato MF,Tonello R,Dalmolin GD,de Almeida Cabrini D,Gomez MV,Ferreira J,Oliveira SM

更新日期：2017-12-01 00:00:00

abstract：:Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand...

journal_title：Molecular neurobiology

authors： Ferrero H,Larrayoz IM,Gil-Bea FJ,Martínez A,Ramírez MJ

更新日期：2018-12-01 00:00:00

abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...

journal_title：Molecular neurobiology

authors： Irwin JL,Yeates AJ,Mulhern MS,McSorley EM,Strain JJ,Watson GE,Grzesik K,Thurston SW,Love TM,Smith TH,Mruzek DW,Shamlaye CF,Monthy C,Myers GJ,Davidson PW,van Wijngaarden E

更新日期：2019-07-01 00:00:00

abstract：:Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also demonstrated toxicity ...

journal_title：Molecular neurobiology

authors： Janssens J,Wils H,Kleinberger G,Joris G,Cuijt I,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S

更新日期：2013-08-01 00:00:00

abstract：:We have recently demonstrated that δ-opioid receptor (DOR) activation attenuates α-synuclein expression/aggregation induced by MPP(+) and/or severe hypoxia. Since α-synuclein plays a critical role in the pathogenesis of Parkinson's disease, DOR activation may trigger an antiparkinson pathway(s) against α-synuclein-ind...

journal_title：Molecular neurobiology

authors： Chen T,Wang Q,Chao D,Xia TC,Sheng S,Li ZR,Zhao JN,Wen GQ,Ding G,Xia Y

更新日期：2019-05-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...

journal_title：Molecular neurobiology

authors： Parga JA,García-Garrote M,Martínez S,Raya Á,Labandeira-García JL,Rodríguez-Pallares J

更新日期：2018-06-01 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival, plasticity, and development and have been implicated in the action mechanism of antidepressants. In this study, we assessed the neurotrophic factor-inducing and neuroprotective properties of antidepressants. In the first part of the study, we found that fluoxet...

journal_title：Molecular neurobiology

authors： Shadfar S,Kim YG,Katila N,Neupane S,Ojha U,Bhurtel S,Srivastav S,Jeong GS,Park PH,Hong JT,Choi DY

更新日期：2018-01-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...

journal_title：Molecular neurobiology

authors： Ettcheto M,Cano A,Manzine PR,Busquets O,Verdaguer E,Castro-Torres RD,García ML,Beas-Zarate C,Olloquequi J,Auladell C,Folch J,Camins A

更新日期：2020-04-01 00:00:00

abstract：:A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific...

journal_title：Molecular neurobiology

authors： Günther OP,Gardy JL,Stafford P,Fluge Ø,Mella O,Tang P,Miller RR,Parker SM,Johnston SA,Patrick DM

更新日期：2019-06-01 00:00:00

abstract：:There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that elevated cholesterol levels are a risk factor for Alzheimer's disease. If elevated cholesterol is a risk factor for Alzheimer's disease, then it would be expected tha...

journal_title：Molecular neurobiology

authors： Wood WG,Igbavboa U,Eckert GP,Johnson-Anuna LN,Müller WE

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are el...

journal_title：Molecular neurobiology

authors： Beste C,Arning L,Gerding WM,Epplen JT,Mertins A,Röder MC,Bless JJ,Hugdahl K,Westerhausen R,Güntürkün O,Ocklenburg S

更新日期：2018-03-01 00:00:00

abstract：:A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...

journal_title：Molecular neurobiology

authors： Zhang G,Xia F,Zhang Y,Zhang X,Cao Y,Wang L,Liu X,Zhao G,Shi M

更新日期：2016-05-01 00:00:00

abstract：:Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...

journal_title：Molecular neurobiology

authors： Sun L,Zhang Z,Xu J,Xu G,Liu X

更新日期：2016-08-01 00:00:00

abstract：:There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....

journal_title：Molecular neurobiology

authors： Mullin AP,Gokhale A,Larimore J,Faundez V

更新日期：2011-08-01 00:00:00

abstract：:Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...

journal_title：Molecular neurobiology

authors： Figiel M,Szlachcic WJ,Switonski PM,Gabka A,Krzyzosiak WJ

更新日期：2012-10-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are enzymes that catalyze the transfer of ADP-ribose units from β-nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins. PARP-1 is responsible for more than 90 % of protein poly-ADP-ribosylation in the brain and may play a role as a molecular switch for cell survival and ...

journal_title：Molecular neurobiology

authors： Banasik M,Stedeford T,Strosznajder RP

更新日期：2012-08-01 00:00:00

abstract：:The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...

journal_title：Molecular neurobiology

authors： Rzemieniec J,Litwa E,Wnuk A,Lason W,Krzeptowski W,Kajta M

更新日期：2016-10-01 00:00:00

abstract：:Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...

journal_title：Molecular neurobiology

authors： Yang H,Liu C,Chen B,An J,Zhang R,Zhang Q,Zhao J,He B,Hao DJ

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, prokineticin 2 (PK2) has been shown to regulate neuron-astrocyte signaling mechanism by promoting an alternative...

journal_title：Molecular neurobiology

authors： Ma M,Li H,Wu J,Zhang Y,Shen H,Li X,Wang Z,Chen G

更新日期：2020-09-01 00:00:00

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...

journal_title：Molecular neurobiology

authors： Wang W,Wang F,Liu J,Zhao W,Zhao Q,He M,Qian BJ,Xu Y,Liu R,Liu SJ,Liu W,Liu J,Zhou XF,Wang TH

更新日期：2014-10-01 00:00:00

abstract：:Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...

journal_title：Molecular neurobiology

authors： Chen M,Puschmann TB,Marasek P,Inagaki M,Pekna M,Wilhelmsson U,Pekny M

更新日期：2018-07-01 00:00:00

abstract：:The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...

journal_title：Molecular neurobiology

authors： Lee B,Baek JI,Min H,Bae SH,Moon K,Kim MA,Kim YR,Fogelgren B,Lipschutz JH,Lee KY,Bok J,Kim UK

更新日期：2018-08-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00