Abstract:
:There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that elevated cholesterol levels are a risk factor for Alzheimer's disease. If elevated cholesterol is a risk factor for Alzheimer's disease, then it would be expected that patients with Alzheimer's disease would have elevated serum and brain cholesterol levels. Studies were reviewed that have examined cholesterol levels in Alzheimer's patients and control subjects, including prospective studies, and based on that review, the conclusion is reached that the majority of studies do not support elevated cholesterol levels in serum and brain as a risk factor for Alzheimer's disease. Alternative hypotheses are discussed, including cholesterol domains and subgroups of individuals with hypercholesteremia.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wood WG,Igbavboa U,Eckert GP,Johnson-Anuna LN,Müller WEdoi
10.1385/MN:31:1-3:185subject
Has Abstractpub_date
2005-01-01 00:00:00pages
185-92issue
1-3eissn
0893-7648issn
1559-1182pii
MN:31:1-3:185journal_volume
31pub_type
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