Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.

abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...

journal_title：Molecular neurobiology

authors： Zhu XC,Wang HF,Jiang T,Lu H,Tan MS,Tan CC,Tan L,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-01-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...

journal_title：Molecular neurobiology

authors： Li Z,Jagadapillai R,Gozal E,Barnes G

更新日期：2019-08-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:During development, neurons migrate to the cortex radially from periventricular germinative zones as well as tangentially from ganglionic eminences. The vast majority of cortical neurons settle radially in the cortical plate. Neuronal migration requires an exquisite regulation of leading edge extension, nuclear transl...

journal_title：Molecular neurobiology

authors： Jossin Y

更新日期：2004-12-01 00:00:00

abstract：:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...

journal_title：Molecular neurobiology

authors： Abdullah AI,Pollock A,Sun T

更新日期：2012-06-01 00:00:00

abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...

journal_title：Molecular neurobiology

authors： Bu XL,Rao PPN,Wang YJ

更新日期：2016-08-01 00:00:00

abstract：:Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...

journal_title：Molecular neurobiology

authors： Shin T,Kim J,Ahn M,Moon C

更新日期：2019-05-01 00:00:00

abstract：:Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of...

journal_title：Molecular neurobiology

authors： Dong S,Huang X,Zhen J,Van Halm-Lutterodt N,Wang J,Zhou C,Yuan L

更新日期：2018-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by intracellular and extracellular protein aggregates, including microtubule-associated protein tau and cleavage product of amyloid precursor protein, β-amyloid (Aβ). Tissue transglutaminase (tTG) is a calcium-dependent enzyme that cross-links proteins forming a γ-glutamyl-ε-l...

journal_title：Molecular neurobiology

authors： Zhang J,Wang S,Huang W,Bennett DA,Dickson DW,Wang D,Wang R

更新日期：2016-10-01 00:00:00

abstract：:Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white matter injury. We inve...

journal_title：Molecular neurobiology

authors： Wu XM,Liu Y,Qian ZM,Luo QQ,Ke Y

更新日期：2016-08-01 00:00:00

abstract：:There is variety of stem cell sources but problems in ethical issues, contamination, and normal karyotype cause many limitations in obtaining and using these cells. The cells in Wharton's jelly region of umbilical cord are abundant and available stem cells with low immunological incompatibility, which could be conside...

journal_title：Molecular neurobiology

authors： Bahrami N,Bayat M,Mohamadnia A,Khakbiz M,Yazdankhah M,Ai J,Ebrahimi-Barough S

更新日期：2017-09-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors...

journal_title：Molecular neurobiology

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Polowy R,Filipkowski RK,Zalewska T

更新日期：2017-09-01 00:00:00

abstract：:A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...

journal_title：Molecular neurobiology

authors： Cieślik M,Czapski GA,Wójtowicz S,Wieczorek I,Wencel PL,Strosznajder RP,Jaber V,Lukiw WJ,Strosznajder JB

更新日期：2020-03-01 00:00:00

abstract：:This work was aimed at investigating the circulating microRNA (miRNA) profiles in serum and saliva of patients affected by fibromyalgia syndrome (FM), correlating their expression values with clinical and clinimetric parameters and to suggest a mathematical model for the diagnosis of FM. A number of 14 FM patients and...

journal_title：Molecular neurobiology

authors： Masotti A,Baldassarre A,Guzzo MP,Iannuccelli C,Barbato C,Di Franco M

更新日期：2017-11-01 00:00:00

abstract：:α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...

journal_title：Molecular neurobiology

authors： Wang Y,Gao A,Xu X,Dang B,You W,Li H,Yu Z,Chen G

更新日期：2015-08-01 00:00:00

abstract：:Nicotine has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unknown....

journal_title：Molecular neurobiology

authors： Liu X,Liu M,Li X,Zhang L,Fan R,Wang J

更新日期：2015-08-01 00:00:00

abstract：:The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible use of sympathetic thoracic ganglia from subjects after brain death as study group. The third left ...

journal_title：Molecular neurobiology

authors： de Moura Júnior NB,das-Neves-Pereira JC,de Campos JR,de Oliveira FR,Wolosker N,Parra ER,Capelozzi VL,Jatene FB

更新日期：2012-04-01 00:00:00

abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...

journal_title：Molecular neurobiology

authors： Wang J,Yu JT,Tan L

更新日期：2015-04-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...

journal_title：Molecular neurobiology

authors： Parga JA,García-Garrote M,Martínez S,Raya Á,Labandeira-García JL,Rodríguez-Pallares J

更新日期：2018-06-01 00:00:00

abstract：:Myeloperoxidase (MPO) has paradoxically been found to be able to both activate matrix metalloproteinases (MMPs) as well as inhibit MMPs. However, these regulatory effects have not yet been observed in vivo, and it is unclear which pathway is relevant in vivo. We aim to track MPO regulation of MMP activity in living an...

journal_title：Molecular neurobiology

authors： Zhang Y,Dong H,Seeburg DP,Wojtkiewicz GR,Waterman P,Pulli B,Forghani R,Ali M,Iwamoto Y,Swirski FK,Chen JW

更新日期：2019-02-01 00:00:00

abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active complex plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, ...

journal_title：Molecular neurobiology

authors： Moncini S,Lunghi M,Valmadre A,Grasso M,Del Vescovo V,Riva P,Denti MA,Venturin M

更新日期：2017-08-01 00:00:00

abstract：:Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...

journal_title：Molecular neurobiology

authors： Figiel M,Szlachcic WJ,Switonski PM,Gabka A,Krzyzosiak WJ

更新日期：2012-10-01 00:00:00

abstract：:A large body of evidences indicates that axonal transport (AT) defects play an important role in the pathogenesis of Alzheimer' disease (AD). AT, a critical cellular process for the maintenance and function of a neuron, requires components of the cytoskeletons as "tracks", motor proteins and ATP as "driving force", ad...

journal_title：Molecular neurobiology

authors： Wang ZX,Tan L,Yu JT

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...

journal_title：Molecular neurobiology

authors： Fröhlich C,Zschiebsch K,Gröger V,Paarmann K,Steffen J,Thurm C,Schropp EM,Brüning T,Gellerich F,Radloff M,Schwabe R,Lachmann I,Krohn M,Ibrahim S,Pahnke J

更新日期：2016-09-01 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...

journal_title：Molecular neurobiology

authors： Wu S,Han Y,Hu Q,Zhang X,Cui G,Li Z,Guan Y

更新日期：2017-05-01 00:00:00

abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...

journal_title：Molecular neurobiology

authors： Matthys A,Haegeman G,Van Craenenbroeck K,Vanhoenacker P

更新日期：2011-06-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...

journal_title：Molecular neurobiology

authors： Eskandari-Sedighi G,Cortez LM,Yang J,Daude N,Shmeit K,Sim V,Westaway D

更新日期：2021-01-01 00:00:00

abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...

journal_title：Molecular neurobiology

authors： Vohra R,Kolko M

更新日期：2020-04-01 00:00:00

abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

journal_title：Molecular neurobiology

authors： Sun L,Tian L,Xu J,Zhang Z,Liu X

更新日期：2017-07-01 00:00:00