Mouse models of polyglutamine diseases: review and data table. Part I.

abstract：:Tenascin-C (TNC), a matricellular protein, is upregulated in brain parenchyma after experimental subarachnoid hemorrhage (SAH). Recent studies emphasize that early brain injury (EBI) should be overcome to improve post-SAH outcomes. The aim of this study was to investigate effects of TNC knockout (TNKO) on neuronal apo...

journal_title：Molecular neurobiology

authors： Liu L,Fujimoto M,Nakano F,Nishikawa H,Okada T,Kawakita F,Imanaka-Yoshida K,Yoshida T,Suzuki H

更新日期：2018-11-01 00:00:00

abstract：:Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Se...

journal_title：Molecular neurobiology

authors： Frozza RL,Bernardi A,Hoppe JB,Meneghetti AB,Matté A,Battastini AM,Pohlmann AR,Guterres SS,Salbego C

更新日期：2013-06-01 00:00:00

abstract：:Dendritic spines, a special kind of structure in nerve cells, play a key role in performing cellular function. Structural abnormalities of the dendritic spine may contribute to synaptic dysfunction and have been implicated in memory formation. However, the molecular mechanisms that trigger dendritic spine loss remain ...

journal_title：Molecular neurobiology

authors： Liu Q,Feng R,Chen Y,Luo G,Yan H,Chen L,Lin R,Ding Y,Wen T

更新日期：2018-01-01 00:00:00

abstract：:Nicotine has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unknown....

journal_title：Molecular neurobiology

authors： Liu X,Liu M,Li X,Zhang L,Fan R,Wang J

更新日期：2015-08-01 00:00:00

abstract：:Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...

journal_title：Molecular neurobiology

authors： Lee ST,Seo Y,Bae JY,Chu K,Kim JW,Choi SH,Kim TM,Kim IH,Park SH,Park CK

更新日期：2018-06-01 00:00:00

abstract：:The human KCTD13 gene is located within the 16p11.2 locus and copy number variants of this locus are associated with a high risk for neuropsychiatric diseases including autism spectrum disorder and schizophrenia. Studies in zebrafish point to a role of KCTD13 in proliferation of neural precursor cells which may contri...

journal_title：Molecular neurobiology

authors： Kizner V,Naujock M,Fischer S,Jäger S,Reich S,Schlotthauer I,Zuckschwerdt K,Geiger T,Hildebrandt T,Lawless N,Macartney T,Dorner-Ciossek C,Gillardon F

更新日期：2020-02-01 00:00:00

abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...

journal_title：Molecular neurobiology

authors： Zendedel A,Johann S,Mehrabi S,Joghataei MT,Hassanzadeh G,Kipp M,Beyer C

更新日期：2016-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...

journal_title：Molecular neurobiology

authors： Wang X,Wang ZH,Wu YY,Tang H,Tan L,Wang X,Gao XY,Xiong YS,Liu D,Wang JZ,Zhu LQ

更新日期：2013-02-01 00:00:00

abstract：:Cerebral ischemia is a cerebrovascular episode that generates a high incidence of death and physical and mental disabilities worldwide. Excitotoxicity, release of free radicals, and exacerbated immune response cause serious complications in motor and cognitive areas during both short and long time frames post-ischemia...

journal_title：Molecular neurobiology

authors： Becerra-Calixto A,Cardona-Gómez GP

更新日期：2017-11-01 00:00:00

abstract：:Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patients. On the histological level, acute axonal injury is most frequently analyzed by anti-amyloid precursor protein immunohistochemistry. To what extent this method truly detects axonal injury, and whether other proteins ...

journal_title：Molecular neurobiology

authors： Rühling S,Kramer F,Schmutz S,Amor S,Jiangshan Z,Schmitz C,Kipp M,Hochstrasser T

更新日期：2019-06-01 00:00:00

abstract：:Galectin-1 (Gal-1) shows neuroprotective activity in brain ischemia, spinal cord injury, and autoimmune neuroinflammation. To evaluate the Gal-1 situation in the brains of prion disease, the brain levels of Gal-1 in several scrapie-infected experimental rodent models were tested by Western blot, including agents 263K-...

journal_title：Molecular neurobiology

authors： Guo YJ,Shi Q,Yang XD,Li JL,Ma Y,Xiao K,Chen C,Han J,Dong XP

更新日期：2017-07-01 00:00:00

abstract：:Loss of heart rate variability (HRV) and autonomic dysfunction are associated with poor outcomes in critically ill patients. Neuronal networks comprising brainstem and hypothalamus are involved in the "flight-or-fight" response via control over the autonomic nervous system and circulation. We hypothesized that sepsis-...

journal_title：Molecular neurobiology

authors： Pinto BB,Ritter C,Michels M,Gambarotta N,Ferrario M,Dal-Pizzol F,Singer M

更新日期：2017-07-01 00:00:00

abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...

journal_title：Molecular neurobiology

authors： Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala G

更新日期：2019-11-01 00:00:00

abstract：:The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...

journal_title：Molecular neurobiology

authors： Yan RT,Ma W,Liang L,Wang SZ

更新日期：2005-10-01 00:00:00

abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...

journal_title：Molecular neurobiology

authors： Fröhlich C,Zschiebsch K,Gröger V,Paarmann K,Steffen J,Thurm C,Schropp EM,Brüning T,Gellerich F,Radloff M,Schwabe R,Lachmann I,Krohn M,Ibrahim S,Pahnke J

更新日期：2016-09-01 00:00:00

abstract：:A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...

journal_title：Molecular neurobiology

authors： Zhang QQ,Jiang T,Gu LZ,Zhu XC,Zhao HD,Gao Q,Zhu HQ,Zhou JS,Zhang YD

更新日期：2016-11-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...

journal_title：Molecular neurobiology

authors： Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD,Yang CC,Yang CM

更新日期：2013-12-01 00:00:00

abstract：:The question of how the cell surface molecules may be specifically delivered to subdomains of neurons is of particular interest considering that polarized sorting to the axon could enable adhesion glycoproteins to induce fasciculation of axonal tracts, guidance to the target cell, and the establishment of synaptic con...

journal_title：Molecular neurobiology

authors： Faivre-Sarrailh C,Rougon G

更新日期：1993-04-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in human...

journal_title：Molecular neurobiology

authors： Mennerick S,Zorumski CF

更新日期：2000-08-01 00:00:00

abstract：:In Alzheimer's disease (AD), excessive amounts of quinolinic acid (QUIN) accumulate within the brain parenchyma and dystrophic neurons. QUIN also regulates glutamate uptake into neurons, which may be due to modulation of Na+-dependent excitatory amino acid transporters (EAATs). To determine the biological relationship...

journal_title：Molecular neurobiology

authors： Braidy N,Alicajic H,Pow D,Smith J,Jugder BE,Brew BJ,Nicolazzo JA,Guillemin GJ

更新日期：2021-01-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson's disease (PD). The aggregation of α-synuclein is believed to be a critical event in the disease process. α-Synuclein is characterized by a remarkable conformational plasticity, adopting different conforma...

journal_title：Molecular neurobiology

authors： Berrocal R,Vasquez V,Rao Krs S,Gadad BS,Rao KS

更新日期：2015-01-01 00:00:00

abstract：:Astrocytes are involved in many key physiological processes in the brain, including glutamatergic transmission, energy metabolism, and blood flow control. They become reactive in response to pathological situations, a response that involves well-described morphological alterations and less characterized functional cha...

journal_title：Molecular neurobiology

authors： Escartin C,Bonvento G

更新日期：2008-12-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...

journal_title：Molecular neurobiology

authors： Mingazov ER,Khakimova GR,Kozina EA,Medvedev AE,Buneeva OA,Bazyan AS,Ugrumov MV

更新日期：2018-04-01 00:00:00

abstract：:YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...

journal_title：Molecular neurobiology

authors： Qin G,Li X,Chen Z,Liao G,Su Y,Chen Y,Zhang W

更新日期：2017-07-01 00:00:00

abstract：:Excess production of reactive oxygen species in the brain has been implicated as a common underlying risk factor for the pathogenesis of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In recent years, there is considerable interest concerning investig...

journal_title：Molecular neurobiology

authors： Sun AY,Wang Q,Simonyi A,Sun GY

更新日期：2010-06-01 00:00:00

abstract：:This study elucidated the potential antidepressant-like effect of prolonged Ropren® administration (8.6 mg/kg, orally, once daily for 28 days) using a β-amyloid (25-35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25-35) i...

journal_title：Molecular neurobiology

authors： Soultanov V,Fedotova J,Nikitina T,Roschin V,Ordyan N,Hritcu L

更新日期：2017-05-01 00:00:00

abstract：:Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line. The present study is an extension...

journal_title：Molecular neurobiology

authors： Freitas AE,Egea J,Buendia I,Gómez-Rangel V,Parada E,Navarro E,Casas AI,Wojnicz A,Ortiz JA,Cuadrado A,Ruiz-Nuño A,Rodrigues ALS,Lopez MG

更新日期：2016-07-01 00:00:00