Abstract：
:Astrocytes are involved in many key physiological processes in the brain, including glutamatergic transmission, energy metabolism, and blood flow control. They become reactive in response to pathological situations, a response that involves well-described morphological alterations and less characterized functional changes. The functional consequences of astrocyte reactivity seem to depend on the molecular pathway involved and may result in the enhancement of several neuroprotective and neurotrophic functions. We propose that a selective and controlled activation of astrocytes may switch these highly pleiotropic cells into therapeutic agents to promote neuron survival and recovery. This may represent a potent therapeutic strategy for many brain diseases in which neurons would benefit from an increased support from activated astrocytes.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Escartin C,Bonvento Gdoi
10.1007/s12035-008-8043-ysubject
Has Abstractpub_date
2008-12-01 00:00:00pages
231-41issue
3eissn
0893-7648issn
1559-1182journal_volume
38pub_type
杂志文章,评审abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...
journal_title：Molecular neurobiology
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pub_type： 杂志文章,评审
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0173-z
更新日期：2017-11-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...
journal_title：Molecular neurobiology
pub_type： 已发布勘误
doi：10.1007/s12035-018-0949-4
更新日期：2018-06-01 00:00:00
