Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4.


:Hyperpalatable diets (HP) impair brain metabolism, and regular physical exercise has an apparent opposite effect. Here, we combined a prior long-term exposure to HP diet followed by physical exercise and evaluated the impact on some neuroenergetic components and on cognitive performance. We assessed the extracellular lactate concentration, expression of monocarboxylate transporters (MCTs), pyruvate dehydrogenase (PDH), and mitochondrial function in the hippocampus. Male C57BL/6J mice were fed 4 months with HP or a control diet. Subsequently, they were divided in the following groups: control diet sedentary (CDS), control diet exercise (CDE), HP diet sedentary (HPS), and HP diet exercise (HPE) (n = 15 per group) and were engaged for an additional 30-day period of voluntary exercise and HP diet. Relative to the control situation, exercise increased MCT1, MCT4, and PDH protein levels, while the HP diet increased MCT1 and MCT4 protein levels. The production of hydrogen peroxide (H2O2) and the mitochondrial membrane potential (∆Ѱm) stimulated by succinate in hippocampal homogenates were not significantly different between groups. ADP phosphorylation and the maximal respiratory rate induced by FCCP showed similar responses between groups, implying a normal mitochondrial function. Also, extracellular brain lactate levels were increased in the HPE group compared to other groups soon after performing the Y-maze task. However, such enhanced lactate levels were not associated with improved memory performance. In summary, hippocampal protein expression levels of MCT1 and 4 were increased by physical exercise and HP diet, whereas PDH was only increased by exercise. These observations indicate that a hippocampal metabolic reprogramming takes place in response to these environmental factors.


Mol Neurobiol


Molecular neurobiology


Portela LV,Brochier AW,Haas CB,de Carvalho AK,Gnoato JA,Zimmer ER,Kalinine E,Pellerin L,Muller AP




Has Abstract


2017-10-01 00:00:00














  • Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.

    abstract::The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Lee B,Baek JI,Min H,Bae SH,Moon K,Kim MA,Kim YR,Fogelgren B,Lipschutz JH,Lee KY,Bok J,Kim UK

    更新日期:2018-08-01 00:00:00

  • Analysis of the Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Traumatic Brain and Spinal Cord Injury: Insight into Recent Advances in Actions of Neurochemokine Agents.

    abstract::CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

    更新日期:2017-04-01 00:00:00

  • P2C-Type ATPases and Their Regulation.

    abstract::P2C-type ATPases are a subfamily of P-type ATPases comprising Na(+)/K(+)-ATPase and H(+)/K(+)-ATPase. Na(+)/K(+)-ATPase is ubiquitously expressed and has been implicated in several neurological diseases, whereas H(+)/K(+)-ATPase is found principally in the colon, stomach, and kidney. Both ATPases have two subunits, α ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Retamales-Ortega R,Vio CP,Inestrosa NC

    更新日期:2016-03-01 00:00:00

  • Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging.

    abstract::Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Miyazaki Y,Ishikawa T,Kamatari YO,Nakagaki T,Takatsuki H,Ishibashi D,Kuwata K,Nishida N,Atarashi R

    更新日期:2019-01-01 00:00:00

  • Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease.

    abstract::Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer's disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Zheng Q,Bi R,Xu M,Zhang DF,Tan LW,Lu YP,Yao YG

    更新日期:2021-01-06 00:00:00

  • Molecular biology of glycinergic neurotransmission.

    abstract::Glycine is a major inhibitory neurotransmitter in the spinal cord and brainstem of vertebrates. Glycine is accumulated into synaptic vesicles by a proton-coupled transport system and released to the synaptic cleft after depolarization of the presynaptic terminal. The inhibitory action of glycine is mediated by pentame...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Zafra F,Aragón C,Giménez C

    更新日期:1997-06-01 00:00:00

  • Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.

    abstract::Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MB

    更新日期:2012-08-01 00:00:00

  • Cerebral Tissue Oxidative Ischemia-Reperfusion Injury in Connection with Experimental Cardiac Arrest and Cardiopulmonary Resuscitation: Effect of Mild Hypothermia and Methylene Blue.

    abstract::The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Wiklund L,Patnaik R,Sharma A,Miclescu A,Sharma HS

    更新日期:2018-01-01 00:00:00

  • Natural patterns of neural activity: how physiological mechanisms are orchestrated to cope with real life.

    abstract::Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has bee...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Kurtz R,Egelhaaf M

    更新日期:2003-02-01 00:00:00

  • PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury.

    abstract::Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression of neurological disorders such as Alzheimer's disease and dementia. The administration of this drug in humans presents several criticisms due to its short half-life, poor stability, and high doses needed to achieve the effect. Th...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Ruozi B,Belletti D,Sharma HS,Sharma A,Muresanu DF,Mössler H,Forni F,Vandelli MA,Tosi G

    更新日期:2015-10-01 00:00:00

  • IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease.

    abstract::Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

    更新日期:2019-04-01 00:00:00

  • Unpredictable Chronic Mild Stress Paradigm Established Effects of Pro- and Anti-inflammatory Cytokine on Neurodegeneration-Linked Depressive States in Hamsters with Brain Endothelial Damages.

    abstract::The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Avolio E,Fazzari G,Mele M,Alò R,Zizza M,Jiao W,Di Vito A,Barni T,Mandalà M,Canonaco M

    更新日期:2017-10-01 00:00:00

  • Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes.

    abstract::The study of sporadic Alzheimer's disease etiology, now more than ever, needs an infusion of new concepts. Despite ongoing interest in Alzheimer's disease, the basis of this entity is not yet clear. At present, the best-established and accepted "culprit" in Alzheimer's disease pathology by most scientists is the amylo...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Pluta R,Jabłoński M,Ułamek-Kozioł M,Kocki J,Brzozowska J,Januszewski S,Furmaga-Jabłońska W,Bogucka-Kocka A,Maciejewski R,Czuczwar SJ

    更新日期:2013-12-01 00:00:00

  • Recruitment by the Repressor Freud-1 of Histone Deacetylase-Brg1 Chromatin Remodeling Complexes to Strengthen HTR1A Gene Repression.

    abstract::Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Souslova T,Mirédin K,Millar AM,Albert PR

    更新日期:2017-12-01 00:00:00

  • Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk.

    abstract::Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,meta分析


    authors: Sun L,Zhang Z,Xu J,Xu G,Liu X

    更新日期:2016-08-01 00:00:00

  • Prognostic Value of YKL-40 in Patients with Glioblastoma: a Systematic Review and Meta-analysis.

    abstract::YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,meta分析,评审


    authors: Qin G,Li X,Chen Z,Liao G,Su Y,Chen Y,Zhang W

    更新日期:2017-07-01 00:00:00

  • Decreased Myocyte Enhancer Factor 2 Levels in the Hippocampus of Huntington's Disease Mice Are Related to Cognitive Dysfunction.

    abstract::People suffering from Huntington's disease (HD) present cognitive deficits. Hippocampal dysfunction has been involved in the HD learning and memory impairment, but proteins leading this dysregulation are not fully characterized. Here, we studied the contribution of the family of transcription factors myocyte enhancer ...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Vidal-Sancho L,Fernández-García S,Solés-Tarrés I,Alberch J,Xifró X

    更新日期:2020-11-01 00:00:00

  • Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease.

    abstract::α-Synuclein aggregation contributes to the Parkinson's disease (PD) pathology in multiple ways-the two most important being the activation of neuroinflammation and mitochondrial dysfunction. Our recent studies have shown the beneficial effects of a heat shock protein (HSP) inducer, carbenoxolone (Cbx), in reducing the...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Thakur P,Nehru B

    更新日期:2015-02-01 00:00:00

  • Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery.

    abstract::Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Quattromani MJ,Pruvost M,Guerreiro C,Backlund F,Englund E,Aspberg A,Jaworski T,Hakon J,Ruscher K,Kaczmarek L,Vivien D,Wieloch T

    更新日期:2018-03-01 00:00:00

  • Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus.

    abstract::Morphine as an opioid is an important drug in the treatment of moderate to severe pain. Several stress factors via generation of nitric oxide (NO) and oxidative stress (OS) are responsible for the adverse effects of morphine-induced analgesia, addiction, and antinociceptive tolerance, including altered Ca2+ concentrat...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Osmanlıoğlu HÖ,Yıldırım MK,Akyuva Y,Yıldızhan K,Nazıroğlu M

    更新日期:2020-08-01 00:00:00

  • Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives.

    abstract::Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamin...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Jamebozorgi K,Taghizadeh E,Rostami D,Pormasoumi H,Barreto GE,Hayat SMG,Sahebkar A

    更新日期:2019-07-01 00:00:00

  • Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke.

    abstract::Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Sun L,Tian L,Xu J,Zhang Z,Liu X

    更新日期:2017-07-01 00:00:00

  • Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans.

    abstract::The survival of an organism depends on its ability to respond to its environment through its senses. The sense of touch is one of the most vital; still, it is the least understood. In the process of touch sensation, a mechanical stimulus is converted into electrical signals. Groundbreaking electrophysiological experim...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Bianchi L

    更新日期:2007-12-01 00:00:00

  • Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons.

    abstract::Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Goswami P,Gupta S,Biswas J,Joshi N,Swarnkar S,Nath C,Singh S

    更新日期:2016-01-01 00:00:00

  • Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries.

    abstract::Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章,评审


    authors: Nakka VP,Prakash-Babu P,Vemuganti R

    更新日期:2016-01-01 00:00:00

  • MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine.

    abstract::Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Mingazov ER,Khakimova GR,Kozina EA,Medvedev AE,Buneeva OA,Bazyan AS,Ugrumov MV

    更新日期:2018-04-01 00:00:00

  • Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations.

    abstract::Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Breydo L,Morgan D,Uversky VN

    更新日期:2016-04-01 00:00:00

  • The Lesion Analysis of Cholinergic Neurons in 5XFAD Mouse Model in the Three-Dimensional Level of Whole Brain.

    abstract::Cholinergic system is very important for many higher brain functions, including learning and memory. Cholinergic neurons, especially those in the basal forebrain, are specifically susceptible in some neurodegenerative diseases, such as in Alzheimer's disease (AD). Here, we studied the cholinergic system lesion effects...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Yan H,Pang P,Chen W,Zhu H,Henok K A,Li H,Wu Z,Ke X,Wu J,Zhang T,Pan K,Pei L,Han Y,Lu Y

    更新日期:2018-05-01 00:00:00

  • The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.

    abstract::The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Sánchez-Blázquez P,Pozo-Rodrigálvarez A,Merlos M,Garzón J

    更新日期:2018-06-01 00:00:00

  • Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron.

    abstract::Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and brain pathology. This hypothesis was examined in...

    journal_title:Molecular neurobiology

    pub_type: 杂志文章


    authors: Sharma A,Muresanu DF,Lafuente JV,Patnaik R,Tian ZR,Buzoianu AD,Sharma HS

    更新日期:2015-10-01 00:00:00