Abstract:
:Glioblastoma (GBM) is a highly aggressive brain cancer with the worst prognosis of any central nervous system disease despite intensive multimodal therapy. Inevitably, glioblastoma is fatal, with recurrence of treatment-resistant tumour growth at distal sites leading to an extremely low median survival rate of 12-15 months from the time of initial diagnosis. With the advent of microarray and gene profiling technology, researchers have investigated trends in genetic alterations and, in this regard, the role of dysregulated microRNAs (highly conserved endogenous small RNA molecules) in glioblastoma has been studied with a view to identifying novel mechanisms of acquired drug resistance and allow for development of microRNA (miRNA)-based therapeutics for GBM patients. Considering the development of miRNA research from initial association to GBM to commercial development of miR-based therapeutics in less than a decade, it is not beyond reasonable doubt to anticipate significant advancements in this field of study, hopefully with the ultimate conclusion of improved patient outcome. This review discusses the recent advancements in miRNA-based therapeutic development for use in glioblastoma treatment and the challenges faced with respect to in vivo and clinical application.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Tivnan A,McDonald KLdoi
10.1007/s12035-013-8464-0subject
Has Abstractpub_date
2013-12-01 00:00:00pages
757-68issue
3eissn
0893-7648issn
1559-1182journal_volume
48pub_type
杂志文章,评审abstract::Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8683-z
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abstract::Parkinson's disease (PD) is a progressive neurodegenerative disease affecting over five million individuals worldwide. The exact molecular events underlying PD pathogenesis are still not clearly known. Glia maturation factor (GMF), a neuroinflammatory protein in the brain plays an important role in the pathogenesis of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
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abstract::Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...
journal_title:Molecular neurobiology
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935629
更新日期:1989-10-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9069-y
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abstract::Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS disease, neurodegenerative disease and control patients. Analysis w...
journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8365-7
更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Molecular neurobiology
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更新日期:2020-02-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
abstract::Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active complex plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0002-4
更新日期:2017-08-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-020-02116-9
更新日期:2021-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0177-8
更新日期:2017-10-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8235-3
更新日期:2012-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0090-1
更新日期:2017-09-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0576-5
更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12035-017-0485-7
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Molecular neurobiology
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9927-x
更新日期:2017-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0437-2
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pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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