Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.

abstract：:Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs although with adve...

journal_title：Molecular neurobiology

authors： Gordillo-Salas M,Pascual-Antón R,Ren J,Greer J,Adell A

更新日期：2020-08-01 00:00:00

abstract：:Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...

journal_title：Molecular neurobiology

authors： Bu W,Liang Q,Zhi L,Maciunas L,Loll PJ,Eckenhoff RG,Covarrubias M

更新日期：2018-02-01 00:00:00

abstract：:Since the discovery of leptin and the central melanocortin circuit, electrophysiological studies have played a major role in elucidating mechanisms underlying energy homeostasis. This review highlights the contribution of findings made by electrophysiological measurements to the current understanding of hypothalamic n...

journal_title：Molecular neurobiology

authors： Ghamari-Langroudi M

更新日期：2012-04-01 00:00:00

abstract：:Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contex...

journal_title：Molecular neurobiology

authors： Jiang L,Mao R,Zhou Q,Yang Y,Cao J,Ding Y,Yang Y,Zhang X,Li L,Xu L

更新日期：2016-03-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...

journal_title：Molecular neurobiology

authors： Perianes-Cachero A,Lobo MVT,Hernández-Pinto AM,Busto R,Lasunción-Ripa MA,Arilla-Ferreiro E,Puebla-Jiménez L

更新日期：2020-02-01 00:00:00

abstract：:A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...

journal_title：Molecular neurobiology

authors： Cieślik M,Czapski GA,Wójtowicz S,Wieczorek I,Wencel PL,Strosznajder RP,Jaber V,Lukiw WJ,Strosznajder JB

更新日期：2020-03-01 00:00:00

abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...

journal_title：Molecular neurobiology

authors： O'Dowd DK,Smith MA

更新日期：1996-12-01 00:00:00

abstract：:Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible for the intramembraneous cleavage of more than 90 type I transmembrane proteins, including Alzheimer's disease (AD)-related amyloid precursor protein (APP). The γ-secretase-mediated cleavage of the APP C-terminal membrane stub leads to...

journal_title：Molecular neurobiology

authors： Zoltowska KM,Berezovska O

更新日期：2018-03-01 00:00:00

abstract：:The Peruvian plant Lepidium meyenii (Maca) has been shown to possess neuroprotective activity both in vitro and in vivo. Previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of Maca, in the endocannabinoid system as fatty acid am...

journal_title：Molecular neurobiology

authors： Almukadi H,Wu H,Böhlke M,Kelley CJ,Maher TJ,Pino-Figueroa A

更新日期：2013-10-01 00:00:00

abstract：:The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...

journal_title：Molecular neurobiology

authors： Wiklund L,Patnaik R,Sharma A,Miclescu A,Sharma HS

更新日期：2018-01-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...

journal_title：Molecular neurobiology

authors： Odorcyk FK,Ribeiro RT,Roginski AC,Duran-Carabali LE,Couto-Pereira NS,Dalmaz C,Wajner M,Netto CA

更新日期：2021-01-08 00:00:00

abstract：:Preconditioning with volatile anesthetics can create an ischemia tolerance against cerebral ischemia-reperfusion injury. We investigated whether ubiquitin conjugase 9 (Ubc9), the E2 conjugase for SUMOylation, is associated with neuroprotection induced by isoflurane preconditioning (IsoPC). In vitro, Ubc9 protein expre...

journal_title：Molecular neurobiology

authors： Tong L,Wu Z,Ran M,Chen Y,Yang L,Zhang H,Zhang L,Dong H,Xiong L

更新日期：2015-01-01 00:00:00

abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

journal_title：Molecular neurobiology

authors： Sun L,Tian L,Xu J,Zhang Z,Liu X

更新日期：2017-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor subtype. Despite that metastasis of GBM beyond the central nervous system (CNS) is rare, its malignancy is attributed to the highly infiltration trait, leading to the difficulty of complete surgical excision. Matrix gla protein (MGP) is a vita...

journal_title：Molecular neurobiology

authors： Fu MH,Wang CY,Hsieh YT,Fang KM,Tzeng SF

更新日期：2018-06-01 00:00:00

abstract：:The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especia...

journal_title：Molecular neurobiology

authors： Schaffer S,Asseburg H,Kuntz S,Muller WE,Eckert GP

更新日期：2012-08-01 00:00:00

abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...

journal_title：Molecular neurobiology

authors： Zhang J,Shipston MJ,Brown SB

更新日期：2010-08-01 00:00:00

abstract：:In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...

journal_title：Molecular neurobiology

authors： Luo H,Cao L,Liang X,Du A,Peng T,Li H

更新日期：2018-10-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Germline and somatic mutations in key genes of the mammalian target of rapamycin (mTOR) pathway have been identified in seizure-associated disorders. mTOR mutations lead to aberrant activation of mTOR signaling, and, although affected neurons are critical for epileptogenesis, the role of mTOR activation in glial cells...

journal_title：Molecular neurobiology

authors： Wang X,Sha L,Sun N,Shen Y,Xu Q

更新日期：2017-01-01 00:00:00

abstract：:Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...

journal_title：Molecular neurobiology

authors： Dyer CA

更新日期：1993-04-01 00:00:00

abstract：:The complications caused by overweight, obesity and type 2 diabetes are one of the main problems that increase morbidity and mortality in developed countries. Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a reg...

journal_title：Molecular neurobiology

authors： Hurtado-Carneiro V,Roncero I,Egger SS,Wenger RH,Blazquez E,Sanz C,Alvarez E

更新日期：2014-10-01 00:00:00

abstract：:Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...

journal_title：Molecular neurobiology

authors： Raina A,Mahajani S,Bähr M,Kügler S

更新日期：2020-01-01 00:00:00

abstract：:Long-chain omega-3 polyunsaturated fatty acids (LC-O3PUFAs) exhibit therapeutic potential for the treatment and prevention of the neurological deficits associated with spinal cord injury (SCI). However, the mechanisms implicated in these protective responses remain unclear. The objective of the present functional meta...

journal_title：Molecular neurobiology

authors： Figueroa JD,De Leon M

更新日期：2014-08-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...

journal_title：Molecular neurobiology

authors： Wu Z,Yang L,Wang Y

更新日期：2014-10-01 00:00:00

abstract：:Heat shock proteins (Hsps) are highly conserved proteins that are induced in response to various physiological and environmental stressors. HspB1 (Hsp27) is a prominent member of the small Hsps family and is strongly induced during the stress response. Notably, HspB1 has powerful neuroprotective effects, increasing th...

journal_title：Molecular neurobiology

authors： O'Reilly AM,Currie RW,Clarke DB

更新日期：2010-10-01 00:00:00

abstract：:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...

journal_title：Molecular neurobiology

authors： Sochocka M,Donskow-Łysoniewska K,Diniz BS,Kurpas D,Brzozowska E,Leszek J

更新日期：2019-03-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron death in the substantia nigra (SN) and subsequent striatal adaptations. Mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) are widely used as a model for PD. To assess the validity of the MPTP mouse model for PD p...

journal_title：Molecular neurobiology

authors： Klemann CJHM,Martens GJM,Poelmans G,Visser JE

更新日期：2016-04-01 00:00:00

abstract：:Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...

journal_title：Molecular neurobiology

authors： Amtul Z,Yang J,Nikolova S,Lee TY,Bartha R,Cechetto DF

更新日期：2018-10-01 00:00:00

abstract：:The neuronal circuit remodels during development as well as in human neuropathologies such as epilepsy. Neurite outgrowth is an obligatory step in these events. We recently reported that alterations in the phosphorylation state of an axon specification/guidance protein, the collapsin response mediator protein 2 (CRMP2...

journal_title：Molecular neurobiology

authors： Moutal A,François-Moutal L,Perez-Miller S,Cottier K,Chew LA,Yeon SK,Dai J,Park KD,Khanna M,Khanna R

更新日期：2016-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease characterized by degeneration of upper and lower motor neurons (MNs), generalized weakness and muscle atrophy. The "neurocentric" view of ALS assumes that the disease primarily affects motor neurons, while muscle alterations only...

journal_title：Molecular neurobiology

authors： Pansarasa O,Rossi D,Berardinelli A,Cereda C

更新日期：2014-04-01 00:00:00