Abstract：
:Statins have proven their effectiveness in the treatment of cardiovascular disease. This class of drugs has also attracted attention as a potential treatment for dissimilar diseases such as certain types of cancers and neurodegenerative diseases. What appears to be a contradiction is that, in the case of cancer, it has been suggested that statins increase apoptosis and alter levels of Bcl-2 family members (e.g., reduce Bcl-2 and increase Bax), whereas studies mainly using noncancerous cells report opposite effects. This review examined studies reporting on the effects of statins on Bcl-2 family members, apoptosis, cell death, and cell protection. Much, but not all, of the evidence supporting the pro-apoptotic effects of statins is based on data in cancer cell lines and the use of relatively high drug concentrations. Studies indicating an anti-apoptotic effect of statins are fewer in number and generally used much lower drug concentrations and normal cells. Those conclusions are not definitive, and certainly, there is a need for additional research to determine if statin repositioning is justified for noncardiovascular diseases.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wood WG,Igbavboa U,Muller WE,Eckert GPdoi
10.1007/s12035-013-8496-5subject
Has Abstractpub_date
2013-10-01 00:00:00pages
308-14issue
2eissn
0893-7648issn
1559-1182journal_volume
48pub_type
杂志文章,评审abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
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journal_title：Molecular neurobiology
pub_type： 已发布勘误
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更新日期：2018-06-01 00:00:00
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