The role of endozepine in the regulation of steroid synthesis.

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...

journal_title：Molecular neurobiology

authors： Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD,Yang CC,Yang CM

更新日期：2013-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by intelligence decline, behavioral disorders and cognitive disability. The purpose of this study was to investigate gene expression in AD, based on published microarray data on Tg2576 mice. Hierarchical Cluster Analysis and Gene Ontol...

journal_title：Molecular neurobiology

authors： Tan L,Wang X,Ni ZF,Zhu X,Wu W,Zhu LQ,Liu D

更新日期：2013-06-01 00:00:00

abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...

journal_title：Molecular neurobiology

authors： Suvarna Y,Maity N,Shivamurthy MC

更新日期：2016-05-01 00:00:00

abstract：:P2C-type ATPases are a subfamily of P-type ATPases comprising Na(+)/K(+)-ATPase and H(+)/K(+)-ATPase. Na(+)/K(+)-ATPase is ubiquitously expressed and has been implicated in several neurological diseases, whereas H(+)/K(+)-ATPase is found principally in the colon, stomach, and kidney. Both ATPases have two subunits, α ...

journal_title：Molecular neurobiology

authors： Retamales-Ortega R,Vio CP,Inestrosa NC

更新日期：2016-03-01 00:00:00

abstract：:Neurodegenerative foldopathies are characterized by aberrant folding of diseased modified proteins, which are major constituents of the intracellular and extracellular lesions. These lesions correlate with the cognitive and/or motor impairment seen in these diseases. The majority of the disease modified proteins in ne...

journal_title：Molecular neurobiology

authors： Jadhav S,Zilka N,Novak M

更新日期：2013-12-01 00:00:00

abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...

journal_title：Molecular neurobiology

authors： Alvarez-Ricartes N,Oliveros-Matus P,Mendoza C,Perez-Urrutia N,Echeverria F,Iarkov A,Barreto GE,Echeverria V

更新日期：2018-10-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a modern socioeconomic burden, mostly due to its long-term complications affecting nearly all tissues. One of them is the brain, whose dysfunctional intracellular quality control mechanisms (namely autophagy) may upregulate apoptosis, leading to cognitive dysfunction and Alzheimer disease (AD)...

journal_title：Molecular neurobiology

authors： Candeias E,Sebastião I,Cardoso S,Carvalho C,Santos MS,Oliveira CR,Moreira PI,Duarte AI

更新日期：2018-05-01 00:00:00

abstract：:Evidence indicates that adverse experiences in early life may be a factor for immune disturbances leading to the depression in adulthood. Recently, a pivotal role in the pathogenesis of depression has been assigned to the activation of the brain Nod-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigate...

journal_title：Molecular neurobiology

authors： Trojan E,Chamera K,Bryniarska N,Kotarska K,Leśkiewicz M,Regulska M,Basta-Kaim A

更新日期：2019-08-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...

journal_title：Molecular neurobiology

authors： Huang HJ,Wang YT,Lin HC,Lee YH,Lin AM

更新日期：2018-01-01 00:00:00

abstract：:Glycine is a major inhibitory neurotransmitter in the spinal cord and brainstem of vertebrates. Glycine is accumulated into synaptic vesicles by a proton-coupled transport system and released to the synaptic cleft after depolarization of the presynaptic terminal. The inhibitory action of glycine is mediated by pentame...

journal_title：Molecular neurobiology

authors： Zafra F,Aragón C,Giménez C

更新日期：1997-06-01 00:00:00

abstract：:Metals perform important functions in the normal physiological system, and alterations in their levels may lead to a number of diseases. Aluminium (Al) has been implicated as a major risk factor, which is linked to several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. On the other h...

journal_title：Molecular neurobiology

authors： Singla N,Dhawan DK

更新日期：2014-10-01 00:00:00

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...

journal_title：Molecular neurobiology

authors： Yang X,Askarova S,Lee JC

更新日期：2010-06-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...

journal_title：Molecular neurobiology

authors： Li J,Li H,Liu J,Feng B,Feng M,Lv B,Cheng S,Yang X

更新日期：2016-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...

journal_title：Molecular neurobiology

authors： Huang L,Lan J,Tang J,Kang Y,Feng X,Wu L,Peng Y

更新日期：2020-11-03 00:00:00

abstract：:The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxy...

journal_title：Molecular neurobiology

authors： Jang W,Park HH,Lee KY,Lee YJ,Kim HT,Koh SH

更新日期：2015-04-01 00:00:00

abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigatin...

journal_title：Molecular neurobiology

authors： Mocelin R,Marcon M,D'ambros S,Mattos J,Sachett A,Siebel AM,Herrmann AP,Piato A

更新日期：2019-02-01 00:00:00

abstract：:The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathoge...

journal_title：Molecular neurobiology

authors： Chelluboina B,Nalamolu KR,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

更新日期：2018-02-01 00:00:00

abstract：:An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...

journal_title：Molecular neurobiology

authors： Zi Y,Yin Z,Xiao W,Liu X,Gao Z,Jiao L,Deng L

更新日期：2015-12-01 00:00:00

abstract：:Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...

journal_title：Molecular neurobiology

authors： Tibullo D,Giallongo C,Puglisi F,Tomassoni D,Camiolo G,Cristaldi M,Brundo MV,Anfuso CD,Lupo G,Stampone T,Li Volti G,Amenta F,Avola R,Bramanti V

更新日期：2018-04-01 00:00:00

abstract：:Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patients. On the histological level, acute axonal injury is most frequently analyzed by anti-amyloid precursor protein immunohistochemistry. To what extent this method truly detects axonal injury, and whether other proteins ...

journal_title：Molecular neurobiology

authors： Rühling S,Kramer F,Schmutz S,Amor S,Jiangshan Z,Schmitz C,Kipp M,Hochstrasser T

更新日期：2019-06-01 00:00:00

abstract：:The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...

journal_title：Molecular neurobiology

authors： Semple E,Shalabi F,Hill JW

更新日期：2019-09-01 00:00:00

abstract：:Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...

journal_title：Molecular neurobiology

authors： Corpas R,Griñán-Ferré C,Rodríguez-Farré E,Pallàs M,Sanfeliu C

更新日期：2019-02-01 00:00:00

abstract：:Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...

journal_title：Molecular neurobiology

authors： Woods SD,Skinner RD,Ricca AM,Brown AT,Lowery JD,Borrelli MJ,Lay JO,Culp WC

更新日期：2013-10-01 00:00:00

abstract：:People suffering from Huntington's disease (HD) present cognitive deficits. Hippocampal dysfunction has been involved in the HD learning and memory impairment, but proteins leading this dysregulation are not fully characterized. Here, we studied the contribution of the family of transcription factors myocyte enhancer ...

journal_title：Molecular neurobiology

authors： Vidal-Sancho L,Fernández-García S,Solés-Tarrés I,Alberch J,Xifró X

更新日期：2020-11-01 00:00:00