Abstract:
:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of retrograde signaling. They have been implicated particularly in long-term potentiation (LTP) and synaptic plasticity. But the basic assumptions about retrograde signaling have not been studied upon for many years. This review focuses on established facts and hypothesis put forward in retrograde signaling.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Suvarna Y,Maity N,Shivamurthy MCdoi
10.1007/s12035-015-9280-5subject
Has Abstractpub_date
2016-05-01 00:00:00pages
2572-8issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-015-9280-5journal_volume
53pub_type
杂志文章,评审abstract::Lactate is an energy substrate in adult brain especially when glucose is withdrawn or only lactate is present as main energy source. Besides, the most abundant lactate transporter in brain-monocarboxylate transporter 1 (MCT1)-was recognized recently. Despite this, MCT1 expressions in central nervous system (CNS) have ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9820-7
更新日期:2017-04-01 00:00:00
abstract::Specific variations in the amino acid sequence of prion protein (PrP) are key determinants of susceptibility to prion diseases. We previously showed that an amino acid substitution specific to canids confers resistance to prion diseases when expressed in mice and demonstrated its dominant-negative protective effect ag...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1535-0
更新日期:2019-09-01 00:00:00
abstract::The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02936609
更新日期:1987-10-01 00:00:00
abstract::Although in-hospital mortality rates for sepsis have decreased, survivors often experience lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long-term complications associated with sepsis. We employed a murine model to examine the influence of age and sex on the brain's response an...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01681-y
更新日期:2019-12-01 00:00:00
abstract::The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1514-5
更新日期:2019-09-01 00:00:00
abstract::Despite the increasing evidence of eye abnormalities, the effects of prenatal exposure to cocaine on the visual system are still poorly understood. This study was aimed at analyzing the qualitative and quantitative organization of the retinal photoreceptor cells (PR) and outer nuclear layer (ONL) after prenatal exposu...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02740686
更新日期:1995-08-01 00:00:00
abstract::Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study, an AD mouse m...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02064-4
更新日期:2020-11-01 00:00:00
abstract::The considerable roles of transcription factors, and the associated signaling molecules that activate them, are well deciphered in the context of various biological processes. One of the important transcription factors, the transforming growth factor-β (TGF-β) pathway, has a profound role in neuronal cell survival-a p...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8988-y
更新日期:2016-01-01 00:00:00
abstract::Microglial activation is a pathological feature of many neurodegenerative diseases and the role of cellular lipids in these diseases is mostly unknown. It was known that the special ether lipid plasmalogens (Pls) were reduced in the brain and blood samples of Alzheimer's disease (AD) patients. It has recently been rep...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1307-2
更新日期:2019-05-01 00:00:00
abstract::Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0450-5
更新日期:2018-02-01 00:00:00
abstract::Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8315-4
更新日期:2012-10-01 00:00:00
abstract::GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9447-0
更新日期:2016-10-01 00:00:00
abstract::Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0596-1
更新日期:2018-05-01 00:00:00
abstract::Cerebellar degeneration is a devastating manifestation of cerebellar-type multiple-system atrophy (MSA), a rapidly progressive neurodegenerative disease, and the exact pathogenesis is unknown. Here, we examined the expression of micro-RNAs (miRNAs), which are short noncoding RNAs, in the cerebellum of MSA and the key ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8788-4
更新日期:2015-02-01 00:00:00
abstract::Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-015-9301-4
更新日期:2016-08-01 00:00:00
abstract::Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:27:3:239
更新日期:2003-06-01 00:00:00
abstract::Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9000-6
更新日期:2016-01-01 00:00:00
abstract::The Peruvian plant Lepidium meyenii (Maca) has been shown to possess neuroprotective activity both in vitro and in vivo. Previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of Maca, in the endocannabinoid system as fatty acid am...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8499-2
更新日期:2013-10-01 00:00:00
abstract::Lafora disease (LD, OMIM 254780, ORPHA501) is a fatal neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called Lafora bodies and caused, in the vast majority of cases, by mutations in either EPM2A or EPM2B genes, encoding respectively laforin and malin. In the last year...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8747-0
更新日期:2015-01-01 00:00:00
abstract::Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the underlying disease pathogenesis. We recently reported that local drug biotransformation at the blood-brain barrier is upregulated by GR, which controls drug-metabolizing enzymes...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02043-9
更新日期:2020-11-01 00:00:00
abstract::There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-011-8183-3
更新日期:2011-08-01 00:00:00
abstract::Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9382-0
更新日期:2016-09-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-9029-6
更新日期:2016-01-01 00:00:00
abstract::Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1444-7
更新日期:2019-07-01 00:00:00
abstract::Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:33:2:81
更新日期:2006-04-01 00:00:00
abstract::Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasop...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02741376
更新日期:1999-02-01 00:00:00
abstract::Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax+/- mice were used to test the hypothesis that lowering the quantity of BAX in RGCs...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01783-7
更新日期:2020-02-01 00:00:00
abstract::Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9652-x
更新日期:2017-01-01 00:00:00
abstract::Tenascin-C (TNC), a matricellular protein, is upregulated in brain parenchyma after experimental subarachnoid hemorrhage (SAH). Recent studies emphasize that early brain injury (EBI) should be overcome to improve post-SAH outcomes. The aim of this study was to investigate effects of TNC knockout (TNKO) on neuronal apo...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1006-z
更新日期:2018-11-01 00:00:00
abstract::Information processing in neurobiological systems is commonly thought to rely on the assessment of a signal-to-noise ratio as the key mechanism of signal detection; it assumes and requires that both signal and noise are concurrently available. An alternative theory holds that detection proceeds by the system appreciat...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:24:1-3:145
更新日期:2001-08-01 00:00:00