The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor.

abstract：:Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...

journal_title：Molecular neurobiology

authors： Tomé-Carneiro J,Carmen Crespo M,Burgos-Ramos E,Tomas-Zapico C,García-Serrano A,Castro-Gómez P,Venero C,Pereda-Pérez I,Baliyan S,Valencia A,Fontecha J,Dávalos A,Visioli F

更新日期：2018-09-01 00:00:00

abstract：:Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations ...

journal_title：Molecular neurobiology

authors： Morris G,Puri BK,Frye RE,Maes M

更新日期：2018-06-01 00:00:00

abstract：:The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input-output connections, and time of neurogenesis. Since it is thought that limbic, reward-related information and executive aspects of behavioral information may be differentially p...

journal_title：Molecular neurobiology

authors： Miura M,Masuda M,Aosaki T

更新日期：2008-04-01 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...

journal_title：Molecular neurobiology

authors： Wang J,Yu JT,Tan L

更新日期：2015-04-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamin...

journal_title：Molecular neurobiology

authors： Jamebozorgi K,Taghizadeh E,Rostami D,Pormasoumi H,Barreto GE,Hayat SMG,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...

journal_title：Molecular neurobiology

authors： Chen X,Chen X,Huang X,Qin C,Fang Y,Liu Y,Zhang G,Pan D,Wang W,Xie M

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this study was to determine whether or not aquaporin-4 (AQP4) gene mutations are related to the pathogenesis of inflammatory demyelinating diseases in the central nervous system. Polymorphisms of AQP4 exons 1-5 were determined by sequencing DNA from 67 patients with central nervous system inflammatory d...

journal_title：Molecular neurobiology

authors： Chu L,Dai Q,Xu Z,He D,Wang H,Wang Q,Zhang Y,Zhu Y,Li Y,Cai G,Slavica K,Allan K

更新日期：2016-07-01 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...

journal_title：Molecular neurobiology

authors： Wu S,Han Y,Hu Q,Zhang X,Cui G,Li Z,Guan Y

更新日期：2017-05-01 00:00:00

abstract：:The administration of the anorexigenic drug d,l-fenfluramine (Ponderax) to laboratory animals results in a dose-dependent reduction in presynaptically located serotonergic reuptake transporter protein. This long-term effect may represent an altered mechanism of synthesis of the transporter (downregulation). Alternativ...

journal_title：Molecular neurobiology

authors： Westphalen RI,Dodd PR

更新日期：1995-08-01 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. Wit...

journal_title：Molecular neurobiology

authors： Tarr TB,Wipf P,Meriney SD

更新日期：2015-08-01 00:00:00

abstract：:The considerable roles of transcription factors, and the associated signaling molecules that activate them, are well deciphered in the context of various biological processes. One of the important transcription factors, the transforming growth factor-β (TGF-β) pathway, has a profound role in neuronal cell survival-a p...

journal_title：Molecular neurobiology

authors： Haque R,Nazir A

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...

journal_title：Molecular neurobiology

authors： Sun L,Zhang Z,Xu J,Xu G,Liu X

更新日期：2016-08-01 00:00:00

abstract：:Oxidative damage to the inner ear is responsible for several types of sensorineural deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative stress. Activated poly(ADP-ribose) polymerase 1 (PARP1) has been implicated in several diseases, but the effect of PARP1 on MCs subjected to o...

journal_title：Molecular neurobiology

authors： Zhang Y,Yang Y,Xie Z,Zuo W,Jiang H,Zhao X,Sun Y,Kong W

更新日期：2016-11-01 00:00:00

abstract：:CRMP1, a member of the collapsin response mediator protein family (CRMPs), was reported to regulate axon outgrowth in Sema3A signaling pathways via interactions with its co-receptor protein neuropilin-1 and plexin-As through the Fyn-cyclin-dependent kinase 5 (CDK5) cascade and the sequential phosphorylation of CRMP1 b...

journal_title：Molecular neurobiology

authors： Yao L,Liu YH,Li X,Ji YH,Yang XJ,Hang XT,Ding ZM,Liu F,Wang YH,Shen AG

更新日期：2016-03-01 00:00:00

abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...

journal_title：Molecular neurobiology

authors： Rivera DS,Lindsay CB,Codocedo JF,Carreño LE,Cabrera D,Arrese MA,Vio CP,Bozinovic F,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...

journal_title：Molecular neurobiology

authors： Wu W,Guan Y,Xu K,Fu XJ,Lei XF,Lei LJ,Zhang ZQ,Cheng Y,Li YQ

更新日期：2016-05-01 00:00:00

abstract：:Depression is a common non-motor symptom in patients with Parkinson's disease (PD) and difficult to treat. Crocin is a natural multipotential neuroprotective compound that has been shown to elicit antidepressant activity and is promising for the therapy of neuropsychological diseases. Here, we investigated the therape...

journal_title：Molecular neurobiology

authors： Tang J,Lu L,Wang Q,Liu H,Xue W,Zhou T,Xu L,Wang K,Wu D,Wei F,Tao W,Chen G

更新日期：2020-07-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Mül...

journal_title：Molecular neurobiology

authors： Wilkerson JL,Stiles MA,Gurley JM,Grambergs RC,Gu X,Elliott MH,Proia RL,Mandal NA

更新日期：2019-10-01 00:00:00

abstract：:Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be altered by self-administration of ketamine, a non-competitive antagonist of the NMDA glutamate receptor, with a...

journal_title：Molecular neurobiology

authors： Caffino L,Piva A,Mottarlini F,Di Chio M,Giannotti G,Chiamulera C,Fumagalli F

更新日期：2018-07-01 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron death in the substantia nigra (SN) and subsequent striatal adaptations. Mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) are widely used as a model for PD. To assess the validity of the MPTP mouse model for PD p...

journal_title：Molecular neurobiology

authors： Klemann CJHM,Martens GJM,Poelmans G,Visser JE

更新日期：2016-04-01 00:00:00

abstract：:Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...

journal_title：Molecular neurobiology

authors： Dos Santos JPA,Vizuete AF,Gonçalves CA

更新日期：2020-01-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also possesses antioxidant activities. However, the underlying mechanisms remain to be fully defined. Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress. Currently, the potential functions of...

journal_title：Molecular neurobiology

authors： Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI

更新日期：2016-08-01 00:00:00

abstract：:Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...

journal_title：Molecular neurobiology

authors： Chen M,Puschmann TB,Marasek P,Inagaki M,Pekna M,Wilhelmsson U,Pekny M

更新日期：2018-07-01 00:00:00

abstract：:Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD ly...

journal_title：Molecular neurobiology

authors： Wojsiat J,Laskowska-Kaszub K,Alquézar C,Białopiotrowicz E,Esteras N,Zdioruk M,Martin-Requero A,Wojda U

更新日期：2017-09-01 00:00:00

abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

journal_title：Molecular neurobiology

authors： García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

更新日期：2017-01-01 00:00:00

abstract：:The chronic stage multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), remains refractory to current treatments. This refractory nature may be due to the fact that current treatments are primarily immunomodulatory, which prevent further demyelination but lack the capacity...

journal_title：Molecular neurobiology

authors： Li X,Zhang Y,Yan Y,Ciric B,Ma CG,Chin J,Curtis M,Rostami A,Zhang GX

更新日期：2017-08-01 00:00:00

abstract：:Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism spectrum disorders. The PSD is a thickness, detectable at electronic microscopy, localized at the postsynaptic membrane of glutamatergic syna...

journal_title：Molecular neurobiology

authors： de Bartolomeis A,Latte G,Tomasetti C,Iasevoli F

更新日期：2014-02-01 00:00:00