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Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus.

Abstract：

:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite clinical and experimental data indicating a role for copper in brain function, the mechanisms and timing of the critical events affected by copper remain poorly understood. A novel role for the Menkes ATPase has been identified in the availability of an N-methyl-D-aspartate (NMDA) receptor-dependent, releasable pool of copper in hippocampal neurons, suggesting a unique mechanism linking copper homeostasis and neuronal activation within the central nervous system. This article explores the evidence that copper acts as a modulator of neuronal transmission, and that the release of endogenous copper from neurons may regulate NMDA receptor activity. The relationship between impaired copper homeostasis and neuropathophysiology suggests that impairment of copper efflux could alter neuronal function and thus contribute to rapid neuronal degeneration.

journal_name

Mol Neurobiol

journal_title

Molecular neurobiology

authors

Schlief ML,Gitlin JD

doi

10.1385/MN:33:2:81

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

81-90

issue

2

eissn

0893-7648

issn

1559-1182

pii

MN:33:2:81

journal_volume

33

pub_type

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