Abstract:
:Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasopressin secretion, effects that involve the modulation of brain noradrenergic pathways. This review focuses on the intracellular events that mediate the functional effects of Ang II in neurons, via AT1 receptors. The signaling pathways involved in short-term changes in neuronal activity, membrane ionic currents, norepinephrine (NE) release, and longer-term neuromodulatory actions of Ang II are discussed. It will be apparent from this discussion that the signaling pathways involved in these events are often distinct.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Richards EM,Raizada MK,Gelband CH,Sumners Cdoi
10.1007/BF02741376subject
Has Abstractpub_date
1999-02-01 00:00:00pages
25-41issue
1eissn
0893-7648issn
1559-1182journal_volume
19pub_type
杂志文章,评审abstract::Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1125-6
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abstract::Microglial activation is a pathological feature of many neurodegenerative diseases and the role of cellular lipids in these diseases is mostly unknown. It was known that the special ether lipid plasmalogens (Pls) were reduced in the brain and blood samples of Alzheimer's disease (AD) patients. It has recently been rep...
journal_title:Molecular neurobiology
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abstract::Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0772-3
更新日期:2018-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935639
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abstract::Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9518-2
更新日期:2016-11-01 00:00:00
abstract::In Alzheimer's disease (AD), excessive amounts of quinolinic acid (QUIN) accumulate within the brain parenchyma and dystrophic neurons. QUIN also regulates glutamate uptake into neurons, which may be due to modulation of Na+-dependent excitatory amino acid transporters (EAATs). To determine the biological relationship...
journal_title:Molecular neurobiology
pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9109-2
更新日期:2016-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0346-9
更新日期:2018-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0969-0
更新日期:2018-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9030-0
更新日期:2016-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/mn:28:3:277
更新日期:2003-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9471-0
更新日期:2016-10-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1263-x
更新日期:2019-04-01 00:00:00
abstract::The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-010-8127-3
更新日期:2010-08-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0322-4
更新日期:2017-12-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02780664
更新日期:1994-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02043-9
更新日期:2020-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935552
更新日期:1991-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9522-6
更新日期:2016-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/mn:33:1:051
更新日期:2006-02-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0706-0
更新日期:2018-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8667-z
更新日期:2014-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-011-8183-3
更新日期:2011-08-01 00:00:00
abstract::Fenpropathrin is one of the widely used pyrethroids in agriculture and household and also reported to have neurotoxic effects in rodent models. In our Parkinson's disease (PD) clinic, there was a unique patient with a history of daily exposure to fenpropathrin for 6 months prior to developing Parkinsonian symptoms pro...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9057-2
更新日期:2016-03-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0123-9
更新日期:2017-10-01 00:00:00
abstract::Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal rare autosomal recessive neurodegenerative disorder characterized by the accumulation of insoluble ubiquitinated polyglucosan inclusions in the cytoplasm of neurons, which is most commonly associated with mutations in two genes: EPM2A, encoding the ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9884-4
更新日期:2017-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8828-0
更新日期:2015-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析,收录出版
doi:10.1007/s12035-014-8823-5
更新日期:2015-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9981-4
更新日期:2017-08-01 00:00:00