The presence of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00

abstract：:Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible stu...

journal_title：Molecular neurobiology

authors： Lv S,Dai C,Liu Y,Shi R,Tang Z,Han M,Bian R,Sun B,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Neurons are able to adjust the sensitivity of receptor-mediated processes according to the level of receptor activation. Extrapolating from our knowledge of other cellular proteins, regulation of receptor mRNA availability would provide a highly economical means of achieving this objective. Epidermal growth factor is ...

journal_title：Molecular neurobiology

authors： Morris BJ

更新日期：1993-10-01 00:00:00

abstract：:Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...

journal_title：Molecular neurobiology

authors： Feng J,Chen X,Guan B,Li C,Qiu J,Shen J

更新日期：2018-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...

journal_title：Molecular neurobiology

authors： Wang X,Wang ZH,Wu YY,Tang H,Tan L,Wang X,Gao XY,Xiong YS,Liu D,Wang JZ,Zhu LQ

更新日期：2013-02-01 00:00:00

abstract：:In the field of the neurobiology of learning, significant emphasis has been placed on understanding neural plasticity within a single structure (or synapse type) as it relates to a particular type of learning mediated by a particular brain area. To appreciate fully the breadth of the plasticity responsible for complex...

journal_title：Molecular neurobiology

authors： Mizumori SJ,Cooper BG,Leutgeb S,Pratt WE

更新日期：2000-02-01 00:00:00

abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...

journal_title：Molecular neurobiology

authors： Lee MJ,Jang M,Choi J,Lee G,Min HJ,Chung WS,Kim JI,Jee Y,Chae Y,Kim SH,Lee SJ,Cho IH

更新日期：2016-04-01 00:00:00

abstract：:Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...

journal_title：Molecular neurobiology

authors： Raina A,Mahajani S,Bähr M,Kügler S

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...

journal_title：Molecular neurobiology

authors： Yang X,Askarova S,Lee JC

更新日期：2010-06-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...

journal_title：Molecular neurobiology

authors： Perianes-Cachero A,Lobo MVT,Hernández-Pinto AM,Busto R,Lasunción-Ripa MA,Arilla-Ferreiro E,Puebla-Jiménez L

更新日期：2020-02-01 00:00:00

abstract：:Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-...

journal_title：Molecular neurobiology

authors： Quattromani MJ,Pruvost M,Guerreiro C,Backlund F,Englund E,Aspberg A,Jaworski T,Hakon J,Ruscher K,Kaczmarek L,Vivien D,Wieloch T

更新日期：2018-03-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...

journal_title：Molecular neurobiology

authors： Lnenicka GA,Hong SJ

更新日期：1997-02-01 00:00:00

abstract：:Several studies support a protective effect of vitamin D on multiple sclerosis and experimental allergic encephalomyelitis (EAE), but the mechanisms of these favorable effects are unclear. Our study demonstrates that sphingosine 1-phosphate (S1P) is upregulated in the serum and spinal cords of EAE rats, but that vitam...

journal_title：Molecular neurobiology

authors： Zhu Y,Qin Z,Gao J,Yang M,Qin Y,Shen T,Liu S

更新日期：2014-12-01 00:00:00

abstract：:Prion pathologies are characterized by the conformational conversion of the cellular prion protein (PrPC) into a pathological infectious isoform, known as PrPSc. The latter acquires different abnormal conformations, which are associated with specific pathological phenotypes. Recent evidence suggests that prions adapt ...

journal_title：Molecular neurobiology

authors： Bistaffa E,Moda F,Virgilio T,Campagnani I,De Luca CMG,Rossi M,Salzano G,Giaccone G,Tagliavini F,Legname G

更新日期：2019-04-01 00:00:00

abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...

journal_title：Molecular neurobiology

authors： Matthys A,Haegeman G,Van Craenenbroeck K,Vanhoenacker P

更新日期：2011-06-01 00:00:00

abstract：:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...

journal_title：Molecular neurobiology

authors： Breydo L,Morgan D,Uversky VN

更新日期：2016-04-01 00:00:00

abstract：:Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Se...

journal_title：Molecular neurobiology

authors： Frozza RL,Bernardi A,Hoppe JB,Meneghetti AB,Matté A,Battastini AM,Pohlmann AR,Guterres SS,Salbego C

更新日期：2013-06-01 00:00:00

abstract：:Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...

journal_title：Molecular neurobiology

authors： Du F,Qian ZM,Luo Q,Yung WH,Ke Y

更新日期：2015-08-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:Lafora disease (LD, OMIM 254780, ORPHA501) is a fatal neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called Lafora bodies and caused, in the vast majority of cases, by mutations in either EPM2A or EPM2B genes, encoding respectively laforin and malin. In the last year...

journal_title：Molecular neurobiology

authors： Romá-Mateo C,Aguado C,García-Giménez JL,Ibáñez-Cabellos JS,Seco-Cervera M,Pallardó FV,Knecht E,Sanz P

更新日期：2015-01-01 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:Since the discovery of leptin and the central melanocortin circuit, electrophysiological studies have played a major role in elucidating mechanisms underlying energy homeostasis. This review highlights the contribution of findings made by electrophysiological measurements to the current understanding of hypothalamic n...

journal_title：Molecular neurobiology

authors： Ghamari-Langroudi M

更新日期：2012-04-01 00:00:00

abstract：:Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...

journal_title：Molecular neurobiology

authors： Dyer CA

更新日期：1993-04-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable ...

journal_title：Molecular neurobiology

authors： Godoy JA,Valdivieso AG,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:There is variety of stem cell sources but problems in ethical issues, contamination, and normal karyotype cause many limitations in obtaining and using these cells. The cells in Wharton's jelly region of umbilical cord are abundant and available stem cells with low immunological incompatibility, which could be conside...

journal_title：Molecular neurobiology

authors： Bahrami N,Bayat M,Mohamadnia A,Khakbiz M,Yazdankhah M,Ai J,Ebrahimi-Barough S

更新日期：2017-09-01 00:00:00

abstract：:Topoisomerase I (topo I) is a nuclear enzyme which participates in most DNA transactions. It was shown to be inhibited in depolarized neurons by poly adenosine diphosphate (ADP)-ribosylation of the enzyme protein. We demonstrated previously an age and sex dependent topo I activity and enzyme protein level in the vario...

journal_title：Molecular neurobiology

authors： Zehorai E,Eitan E,Hershfinkel M,Sekler I,Priel E

更新日期：2008-12-01 00:00:00

abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...

journal_title：Molecular neurobiology

authors： Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala G

更新日期：2019-11-01 00:00:00

abstract：:HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we investigated how ox...

journal_title：Molecular neurobiology

authors： Sivalingam K,Cirino TJ,McLaughlin JP,Samikkannu T

更新日期：2021-02-01 00:00:00

abstract：:We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...

journal_title：Molecular neurobiology

authors： Lopez JR,Uryash A,Kolster J,Estève E,Zhang R,Adams JA

更新日期：2018-11-01 00:00:00