Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.

abstract：:Ischemic stroke, caused by obstruction of blood flow to the brain, would initiate microglia activation which contributes to neuronal damage. Therefore, inhibition of microglia-mediated neuroinflammation could be a therapeutic strategy for ischemic stroke. This study was aimed to elucidate the anti-inflammatory effects...

journal_title：Molecular neurobiology

authors： Wu MH,Huang CC,Chio CC,Tsai KJ,Chang CP,Lin NK,Lin MT

更新日期：2016-09-01 00:00:00

abstract：:Fenpropathrin is one of the widely used pyrethroids in agriculture and household and also reported to have neurotoxic effects in rodent models. In our Parkinson's disease (PD) clinic, there was a unique patient with a history of daily exposure to fenpropathrin for 6 months prior to developing Parkinsonian symptoms pro...

journal_title：Molecular neurobiology

authors： Xiong J,Zhang X,Huang J,Chen C,Chen Z,Liu L,Zhang G,Yang J,Zhang Z,Zhang Z,Lin Z,Xiong N,Wang T

更新日期：2016-03-01 00:00:00

abstract：:There is variety of stem cell sources but problems in ethical issues, contamination, and normal karyotype cause many limitations in obtaining and using these cells. The cells in Wharton's jelly region of umbilical cord are abundant and available stem cells with low immunological incompatibility, which could be conside...

journal_title：Molecular neurobiology

authors： Bahrami N,Bayat M,Mohamadnia A,Khakbiz M,Yazdankhah M,Ai J,Ebrahimi-Barough S

更新日期：2017-09-01 00:00:00

abstract：:Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information processing in the brain. The growth and complexity of dendritic arbors are driven by the formation of synapses alo...

journal_title：Molecular neurobiology

authors： Lira M,Arancibia D,Orrego PR,Montenegro-Venegas C,Cruz Y,García J,Leal-Ortiz S,Godoy JA,Gundelfinger ED,Inestrosa NC,Garner CC,Zamorano P,Torres VI

更新日期：2019-07-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:The escalating burden of type 2 diabetes (T2D) and its related complications has become a major public health challenge worldwide. Substantial evidence indicates that T2D is one of the culprits for the high prevalence of Alzheimer's disease (AD) in diabetic subjects. This study aimed to investigate the possible mitoch...

journal_title：Molecular neurobiology

authors： Bhatti JS,Thamarai K,Kandimalla R,Manczak M,Yin X,Kumar S,Vijayan M,Reddy PH

更新日期：2021-02-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junction...

journal_title：Molecular neurobiology

authors： Rörig B,Sutor B

更新日期：1996-06-01 00:00:00

abstract：:Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...

journal_title：Molecular neurobiology

authors： Goswami P,Gupta S,Biswas J,Joshi N,Swarnkar S,Nath C,Singh S

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to determine whether or not aquaporin-4 (AQP4) gene mutations are related to the pathogenesis of inflammatory demyelinating diseases in the central nervous system. Polymorphisms of AQP4 exons 1-5 were determined by sequencing DNA from 67 patients with central nervous system inflammatory d...

journal_title：Molecular neurobiology

authors： Chu L,Dai Q,Xu Z,He D,Wang H,Wang Q,Zhang Y,Zhu Y,Li Y,Cai G,Slavica K,Allan K

更新日期：2016-07-01 00:00:00

abstract：:c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...

journal_title：Molecular neurobiology

authors： Petrov D,Luque M,Pedrós I,Ettcheto M,Abad S,Pallàs M,Verdaguer E,Auladell C,Folch J,Camins A

更新日期：2016-11-01 00:00:00

abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...

journal_title：Molecular neurobiology

authors： Alvarez-Ricartes N,Oliveros-Matus P,Mendoza C,Perez-Urrutia N,Echeverria F,Iarkov A,Barreto GE,Echeverria V

更新日期：2018-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...

journal_title：Molecular neurobiology

authors： Garcez ML,Mina F,Bellettini-Santos T,da Luz AP,Schiavo GL,Macieski JMC,Medeiros EB,Marques AO,Magnus NQ,Budni J

更新日期：2019-04-01 00:00:00

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...

journal_title：Molecular neurobiology

authors： Rothan HA,Fang S,Mahesh M,Byrareddy SN

更新日期：2019-04-01 00:00:00

abstract：:Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contex...

journal_title：Molecular neurobiology

authors： Jiang L,Mao R,Zhou Q,Yang Y,Cao J,Ding Y,Yang Y,Zhang X,Li L,Xu L

更新日期：2016-03-01 00:00:00

abstract：:There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigatin...

journal_title：Molecular neurobiology

authors： Mocelin R,Marcon M,D'ambros S,Mattos J,Sachett A,Siebel AM,Herrmann AP,Piato A

更新日期：2019-02-01 00:00:00

abstract：:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...

journal_title：Molecular neurobiology

authors： Shin T,Ahn M,Moon C,Kim S,Sim KB

更新日期：2013-06-01 00:00:00

abstract：:The endocannabinoid system (ECS) actively participates in several physiological processes within the central nervous system. Among such, its involvement in the downregulation of the N-methyl-D-aspartate receptor (NMDAr) through a modulatory input at the cannabinoid receptors (CBr) has been established. After its produ...

journal_title：Molecular neurobiology

authors： Aguilera-Portillo G,Rangel-López E,Villeda-Hernández J,Chavarría A,Castellanos P,Elmazoglu Z,Karasu Ç,Túnez I,Pedraza G,Königsberg M,Santamaría A

更新日期：2019-02-01 00:00:00

abstract：:Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...

journal_title：Molecular neurobiology

authors： Brusco I,Silva CR,Trevisan G,de Campos Velho Gewehr C,Rigo FK,La Rocca Tamiozzo L,Rossato MF,Tonello R,Dalmolin GD,de Almeida Cabrini D,Gomez MV,Ferreira J,Oliveira SM

更新日期：2017-12-01 00:00:00

abstract：:Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...

journal_title：Molecular neurobiology

authors： Dos Santos JPA,Vizuete AF,Gonçalves CA

更新日期：2020-01-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease characterized by degeneration of upper and lower motor neurons (MNs), generalized weakness and muscle atrophy. The "neurocentric" view of ALS assumes that the disease primarily affects motor neurons, while muscle alterations only...

journal_title：Molecular neurobiology

authors： Pansarasa O,Rossi D,Berardinelli A,Cereda C

更新日期：2014-04-01 00:00:00

abstract：:Brain injuries such as trauma and stroke lead to glial scar formation by reactive astrocytes which produce and secret axonal outgrowth inhibitors. Chondroitin sulfate proteoglycans (CSPG) constitute a well-known class of extracellular matrix molecules produced at the glial scar and cause growth cone collapse. The CSPG...

journal_title：Molecular neurobiology

authors： Galindo LT,Mundim MTVV,Pinto AS,Chiarantin GMD,Almeida MES,Lamers ML,Horwitz AR,Santos MF,Porcionatto M

更新日期：2018-04-01 00:00:00

abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...

journal_title：Molecular neurobiology

authors： Ulusoy A,Di Monte DA

更新日期：2013-04-01 00:00:00

abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...

journal_title：Molecular neurobiology

authors： Bu XL,Rao PPN,Wang YJ

更新日期：2016-08-01 00:00:00

abstract：:A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electro...

journal_title：Molecular neurobiology

authors： Wang Z,Nudelman A,Storm DR

更新日期：2007-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...

journal_title：Molecular neurobiology

authors： Lieberknecht V,Junqueira SC,Cunha MP,Barbosa TA,de Souza LF,Coelho IS,Santos AR,Rodrigues AL,Dafré AL,Dutra RC

更新日期：2017-03-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00