Abstract：
:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of particular interest because of the potential to treat diseases of the nervous system, such as neurodegenerative disorders and spinal cord injuries, with cell replacement therapy. Recent advances in cell fate reprogramming have led to the development of novel methods for the direct conversion of fibroblasts into neurons and neural stem cells. This review will highlight the advantages of these new methods over neuronal induction from embryonic stem cells and induced pluripotent stem cells, as well as outline the limitations and the potential for future applications.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Abdullah AI,Pollock A,Sun Tdoi
10.1007/s12035-012-8277-6subject
Has Abstractpub_date
2012-06-01 00:00:00pages
586-95issue
3eissn
0893-7648issn
1559-1182journal_volume
45pub_type
杂志文章,评审abstract：:Accumulating evidence indicates a critical implication of DNA methylation in the brain development. We aim to determine whether the disruption of DNA methylation patterns in the developing brain adversely affects neurobehavioral phenotypes later in life in a sex-dependent manner. 5-Aza-2'-deoxycytidine (5-Aza), a DNA ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9957-4
更新日期：2017-08-01 00:00:00
abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-9787-4
更新日期：2017-04-01 00:00:00
abstract：:The purpose of this study was to determine whether or not aquaporin-4 (AQP4) gene mutations are related to the pathogenesis of inflammatory demyelinating diseases in the central nervous system. Polymorphisms of AQP4 exons 1-5 were determined by sequencing DNA from 67 patients with central nervous system inflammatory d...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9171-9
更新日期：2016-07-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02183-y
更新日期：2020-11-03 00:00:00
abstract：:Major depression is a serious side effect of interferon-α (IFN-α), which is used in the therapy of hepatitis C virus (HCV) infection. Due to the lack of reproducible animal models, the mechanisms underlying IFN-α-related depression are largely unknown. We herein established a mouse model, in which murine IFN-α (250 IU...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8861-z
更新日期：2015-08-01 00:00:00
abstract：:The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0033-y
更新日期：2007-10-01 00:00:00
abstract：:Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9968-1
更新日期：2017-08-01 00:00:00
abstract：:Establishment of appropriate neuronal connections during development and regeneration requires the extension of processes that must then grow in the correct direction, find and recognize their targets, and make synapses with them. During development, embryonic neurons gradually establish central and peripheral connect...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02816122
更新日期：1994-08-01 00:00:00
abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9748-y
更新日期：2017-03-01 00:00:00
abstract：:Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0173-z
更新日期：2017-11-01 00:00:00
abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1424-y
更新日期：2019-07-01 00:00:00
abstract：:Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tag...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1072-2
更新日期：2019-01-01 00:00:00
abstract：:While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0832-8
更新日期：2018-07-01 00:00:00
abstract：:The gammaretroviral human endogenous retrovirus (HERV) families MRSV/HERV-W and HERV-H (including the closely related HERV-Fc1) are associated with an increased risk of multiple sclerosis (MS). Complete HERV sequences betray their endogenous retroviral origin, with open reading frames in gag, pro, pol and env being fl...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1255-x
更新日期：2019-04-01 00:00:00
abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9587-2
更新日期：2017-01-01 00:00:00
abstract：:Astrocytes comprise the major cell type in the central nervous system (CNS) and they are essential for support of neuronal functions by providing nutrients and regulating cell-to-cell communication. Astrocytes also are immune-like cells that become reactive in response to neuronal injury. Phospholipases A2 (PLA2) are ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:31:1-3:027
更新日期：2005-01-01 00:00:00
abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-019-1504-7
更新日期：2019-09-01 00:00:00
abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1302-7
更新日期：2019-05-01 00:00:00
abstract：:A large body of evidences indicates that axonal transport (AT) defects play an important role in the pathogenesis of Alzheimer' disease (AD). AT, a critical cellular process for the maintenance and function of a neuron, requires components of the cytoskeletons as "tracks", motor proteins and ATP as "driving force", ad...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8810-x
更新日期：2015-01-01 00:00:00
abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-019-01863-8
更新日期：2020-04-01 00:00:00
abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:27:3:239
更新日期：2003-06-01 00:00:00
abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0726-9
更新日期：2018-01-01 00:00:00
abstract：:Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly under...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0080-3
更新日期：2017-09-01 00:00:00
abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9012-2
更新日期：2016-04-01 00:00:00
abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02277-7
更新日期：2021-01-28 00:00:00
abstract：:Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01718-2
更新日期：2020-01-01 00:00:00
abstract：:CRMP1, a member of the collapsin response mediator protein family (CRMPs), was reported to regulate axon outgrowth in Sema3A signaling pathways via interactions with its co-receptor protein neuropilin-1 and plexin-As through the Fyn-cyclin-dependent kinase 5 (CDK5) cascade and the sequential phosphorylation of CRMP1 b...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9049-2
更新日期：2016-03-01 00:00:00
abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02816114
更新日期：1994-08-01 00:00:00
abstract：:Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD ly...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0105-y
更新日期：2017-09-01 00:00:00
abstract：:Maternal folate status during pregnancy may influence central nervous system (CNS) development in offspring. However, the recommended intakes of folic acid for women of childbearing age differ among countries and there is still no consensus about whether folic acid should be supplemented continuously throughout pregna...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0534-2
更新日期：2018-03-01 00:00:00
