New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases.

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...

journal_title：Molecular neurobiology

authors： Konar A,Thakur MK

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. A defining hallmark of the AD brain is the presence of intraneuronal neurofibrillary tangles (NFTs) which are made up of abnormally modified tau, with aberrant phosphorylation being the most studied posttranslational modification (PTM)...

journal_title：Molecular neurobiology

authors： Guha S,Johnson GVW,Nehrke K

更新日期：2020-12-01 00:00:00

abstract：:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...

journal_title：Molecular neurobiology

authors： Abdullah AI,Pollock A,Sun T

更新日期：2012-06-01 00:00:00

abstract：:Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...

journal_title：Molecular neurobiology

authors： Du F,Qian ZM,Luo Q,Yung WH,Ke Y

更新日期：2015-08-01 00:00:00

abstract：:We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...

journal_title：Molecular neurobiology

authors： Ahn SM,Kim YR,Shin YI,Ha KT,Lee SY,Shin HK,Choi BT

更新日期：2019-01-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...

journal_title：Molecular neurobiology

authors： Ribeiro FM,Pires RG,Ferguson SS

更新日期：2011-02-01 00:00:00

abstract：:Loss of heart rate variability (HRV) and autonomic dysfunction are associated with poor outcomes in critically ill patients. Neuronal networks comprising brainstem and hypothalamus are involved in the "flight-or-fight" response via control over the autonomic nervous system and circulation. We hypothesized that sepsis-...

journal_title：Molecular neurobiology

authors： Pinto BB,Ritter C,Michels M,Gambarotta N,Ferrario M,Dal-Pizzol F,Singer M

更新日期：2017-07-01 00:00:00

abstract：:Chronic hyperammonemia impairs spatial memory by altering membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus. Intracerebral administration of extracellular cGMP to hyperammonemic rats restores spatial memory and membrane expression of AMPA receptors. The underlying molecular mechanisms re...

journal_title：Molecular neurobiology

authors： Taoro-Gonzalez L,Arenas YM,Cabrera-Pastor A,Felipo V

更新日期：2019-06-01 00:00:00

abstract：:Classical galactosemia is an inborn error of carbohydrate metabolism in which patients accumulate high concentration of galactose in the brain. The most common treatment is a galactose-restricted diet. However, even treated patients develop several complications. One of the most common symptoms is motor coordination i...

journal_title：Molecular neurobiology

authors： Rodrigues AF,Biasibetti H,Zanotto BS,Sanches EF,Schmitz F,Nunes VT,Pierozan P,Manfredini V,Magro DDD,Netto CA,Wyse ATS

更新日期：2017-08-01 00:00:00

abstract：:A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...

journal_title：Molecular neurobiology

authors： Zhang QQ,Jiang T,Gu LZ,Zhu XC,Zhao HD,Gao Q,Zhu HQ,Zhou JS,Zhang YD

更新日期：2016-11-01 00:00:00

abstract：:The 22q11.2 deletion has been identified as a risk factor for multiple neurodevelopmental disorders. Behavioral and cognitive impairments are common among carriers of the 22q11.2 deletion. Parvalbumin expressing (PV+) interneurons provide perisomatic inhibition of excitatory neuronal circuits through GABAA receptors, ...

journal_title：Molecular neurobiology

authors： Al-Absi AR,Qvist P,Okujeni S,Khan AR,Glerup S,Sanchez C,Nyengaard JR

更新日期：2020-12-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a severe deficiency in the activity of the branched-chain α-keto acid dehydrogenase complex, leading to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine. Infections have a significant role in precipitating ...

journal_title：Molecular neurobiology

authors： Scaini G,Morais MO,Galant LS,Vuolo F,Dall'Igna DM,Pasquali MA,Ramos VM,Gelain DP,Moreira JC,Schuck PF,Ferreira GC,Soriano FG,Dal-Pizzol F,Streck EL

更新日期：2014-10-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...

journal_title：Molecular neurobiology

authors： Eskandari-Sedighi G,Cortez LM,Yang J,Daude N,Shmeit K,Sim V,Westaway D

更新日期：2021-01-01 00:00:00

abstract：:Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...

journal_title：Molecular neurobiology

authors： Song Q,Deng Y,Yang X,Bai Y,Xu B,Liu W,Zheng W,Wang C,Zhang M,Xu Z

更新日期：2016-12-01 00:00:00

abstract：:In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...

journal_title：Molecular neurobiology

authors： Luo H,Cao L,Liang X,Du A,Peng T,Li H

更新日期：2018-10-01 00:00:00

abstract：:Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand...

journal_title：Molecular neurobiology

authors： Ferrero H,Larrayoz IM,Gil-Bea FJ,Martínez A,Ramírez MJ

更新日期：2018-12-01 00:00:00

abstract：:Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...

journal_title：Molecular neurobiology

authors： Neves LMS,Gonçalves ECD,Cavalli J,Vieira G,Laurindo LR,Simões RR,Coelho IS,Santos ARS,Marcolino AM,Cola M,Dutra RC

更新日期：2018-07-01 00:00:00

abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...

journal_title：Molecular neurobiology

authors： Cairns BE,O'Brien M,Dong XD,Gazerani P

更新日期：2017-07-01 00:00:00

abstract：:A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...

journal_title：Molecular neurobiology

authors： Zhang G,Xia F,Zhang Y,Zhang X,Cao Y,Wang L,Liu X,Zhao G,Shi M

更新日期：2016-05-01 00:00:00

abstract：:Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...

journal_title：Molecular neurobiology

authors： Kim J,Ghadery C,Cho SS,Mihaescu A,Christopher L,Valli M,Houle S,Strafella AP

更新日期：2019-11-01 00:00:00

abstract：:The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the development...

journal_title：Molecular neurobiology

authors： Sun Y,Cheng X,Zhang L,Hu J,Chen Y,Zhan L,Gao Z

更新日期：2017-03-01 00:00:00

abstract：:Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of...

journal_title：Molecular neurobiology

authors： Dong S,Huang X,Zhen J,Van Halm-Lutterodt N,Wang J,Zhou C,Yuan L

更新日期：2018-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...

journal_title：Molecular neurobiology

authors： Jindal V

更新日期：2018-11-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...

journal_title：Molecular neurobiology

authors： Serratto GM,Pizzi E,Murru L,Mazzoleni S,Pelucchi S,Marcello E,Mazzanti M,Passafaro M,Bassani S

更新日期：2020-12-01 00:00:00

abstract：:Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tag...

journal_title：Molecular neurobiology

authors： Stenovec M,Lasič E,Dominkuš PP,Bobnar ST,Zorec R,Lenassi M,Kreft M

更新日期：2019-01-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:Early-onset familial Alzheimer's disease (AD) is most commonly associated with the mutations in presenilin-1 (PS1). PS1 is the catalytic component of the γ-secretase complex, which cleaves amyloid precursor protein to produce amyloid-β (Aβ), the major cause of AD. Presenilin enhancer 2 (Pen2) is critical for activatin...

journal_title：Molecular neurobiology

authors： Chen WT,Hsieh YF,Huang YJ,Lin CC,Lin YT,Liu YC,Lien CC,Cheng IH

更新日期：2015-12-01 00:00:00